CHICK:WNT3A

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	WNT3A
Protein Name(s)	Protein Wnt-3a
External Links
UniProt	Q2LMP1
EMBL	AB024080 DQ022307 EF068232
RefSeq	NP_001165072.1 NP_990006.2
UniGene	Gga.209
STRING	9031.ENSGALP00000030667
PaxDb	Q2LMP1
Ensembl	ENSGALT00000031304
GeneID	395396
KEGG	gga:395396
CTD	89780
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039529
HOVERGEN	HBG001595
InParanoid	Q2LMP1
KO	K00312
PhylomeDB	Q2LMP1
Reactome	REACT_197822 REACT_203291 REACT_203925 REACT_208332 REACT_224234 REACT_243814 REACT_245585
NextBio	20815480
PRO	PR:Q2LMP1
Proteomes	UP000000539
ExpressionAtlas	Q2LMP1
GO	GO:0009986 GO:0005615 GO:0005578 GO:0005109 GO:0003713 GO:0090245 GO:0007411 GO:0030509 GO:0060070 GO:0061317 GO:0045165 GO:0021846 GO:0034613 GO:0010387 GO:0061303 GO:0048263 GO:0021904 GO:0009953 GO:0030198 GO:0001947 GO:0030097 GO:0021766 GO:0042472 GO:0060173 GO:0035108 GO:0048843 GO:0045599 GO:0003136 GO:0030182 GO:0001649 GO:0060021 GO:0048343 GO:0070527 GO:0030890 GO:2000081 GO:2000727 GO:0035413 GO:2000049 GO:0048697 GO:0043280 GO:0061184 GO:0045743 GO:0048337 GO:0033138 GO:0032092 GO:0061098 GO:0002092 GO:0051091 GO:0045944 GO:0036342 GO:0070507 GO:0035914 GO:0021527 GO:0021874
InterPro	IPR005817 IPR009141 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01843 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:12006981^[1]	ECO:0000316		UniProtKB:Q90722	P		Figure 2 B Shows that both Wnt3A and FGF8 together induce the expression of wnt8c in stage 4 rostral forebrain cells. The method they used was RT-PCR.	complete CACAO 11023
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:11290326^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	PMID:11290326^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:9596583^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048263	determination of dorsal identity	PMID:9473323^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:9596583^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0035108)	Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	PMID:9596583^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061303	cornea development in camera-type eye	PMID:16258938^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17488271^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:15110715^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002329) occurs_in:(UBERON:0004290) occurs_in:(UBERON:0003082)	Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	PMID:18037380^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	PMID:12941626^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010831	positive regulation of myotube differentiation	PMID:18037380^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15110715^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18037380^[8]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17488271^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	PMID:15110715^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18037380^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17488271^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19850029^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009141	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:17488271^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:15110715^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002329) occurs_in:(UBERON:0004290) occurs_in:(UBERON:0003082)	Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	PMID:12941626^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15110715^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17488271^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	PMID:15110715^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	PMID:11290326^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	PMID:11290326^[2] PMID:16575901^[12] PMID:16575901^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048263	determination of dorsal identity	PMID:9473323^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	PMID:11290326^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:9473323^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nordström, U et al. (2002) Progressive induction of caudal neural character by graded Wnt signaling. Nat. Neurosci. 5 525-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kawakami, Y et al. (2001) WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell 104 891-900 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kengaku, M et al. (1998) Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280 1274-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Capdevila, J et al. (1998) Control of dorsoventral somite patterning by Wnt-1 and beta-catenin. Dev. Biol. 193 182-94 PubMed GONUTS page
↑ Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Narita, T et al. (2007) A Wnt3a variant participates in chick apical ectodermal ridge formation: distinct biological activities of Wnt3a splice variants in chick limb development. Dev. Growth Differ. 49 493-501 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Galli, LM et al. (2004) A proliferative role for Wnt-3a in chick somites. Dev. Biol. 269 489-504 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Portilho, DM et al. (2007) A soluble and active form of Wnt-3a protein is involved in myogenic differentiation after cholesterol depletion. FEBS Lett. 581 5787-95 PubMed GONUTS page
↑ ^9.0 ^9.1 Stevens, CB et al. (2003) Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Dev. Biol. 261 149-64 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page
↑ ^12.0 ^12.1 Dong, YF et al. (2006) Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J. Cell. Physiol. 208 77-86 PubMed GONUTS page

[PMID:12006981-1] Nordström, U et al. (2002) Progressive induction of caudal neural character by graded Wnt signaling. Nat. Neurosci. 5 525-32 PubMed GONUTS page

[PMID:11290326-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kawakami, Y et al. (2001) WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell 104 891-900 PubMed GONUTS page

[PMID:9596583-3] 3.0 ^3.1 ^3.2 Kengaku, M et al. (1998) Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280 1274-7 PubMed GONUTS page

[PMID:9473323-4] 4.0 ^4.1 ^4.2 Capdevila, J et al. (1998) Control of dorsoventral somite patterning by Wnt-1 and beta-catenin. Dev. Biol. 193 182-94 PubMed GONUTS page

[PMID:16258938-5] Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page

[PMID:17488271-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Narita, T et al. (2007) A Wnt3a variant participates in chick apical ectodermal ridge formation: distinct biological activities of Wnt3a splice variants in chick limb development. Dev. Growth Differ. 49 493-501 PubMed GONUTS page

[PMID:15110715-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Galli, LM et al. (2004) A proliferative role for Wnt-3a in chick somites. Dev. Biol. 269 489-504 PubMed GONUTS page

[PMID:18037380-8] 8.0 ^8.1 ^8.2 ^8.3 Portilho, DM et al. (2007) A soluble and active form of Wnt-3a protein is involved in myogenic differentiation after cholesterol depletion. FEBS Lett. 581 5787-95 PubMed GONUTS page

[PMID:12941626-9] 9.0 ^9.1 Stevens, CB et al. (2003) Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Dev. Biol. 261 149-64 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19850029-11] Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page

[PMID:16575901-12] 12.0 ^12.1 Dong, YF et al. (2006) Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. J. Cell. Physiol. 208 77-86 PubMed GONUTS page

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CHICK:WNT3A

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