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PMID:12006981
| Citation |
Nordström, U, Jessell, TM and Edlund, T (2002) Progressive induction of caudal neural character by graded Wnt signaling. Nat. Neurosci. 5:525-32 |
|---|---|
| Abstract |
Early in differentiation, all neural cells have a rostral character. Only later do posteriorly positioned neural cells acquire characteristics of caudal forebrain, midbrain and hindbrain cells. Caudalization of neural tissue in the chick embryo apparently involves the convergent actions of (i) fibroblast growth factor (FGF) signaling and (ii) signaling from the caudal paraxial mesoderm, or 'PMC activity', which has not yet been defined molecularly. Here we report evidence that Wnt signaling underlies PMC activity, and show that Wnt signals act directly and in a graded manner on anterior neural cells to induce their progressive differentiation into caudal forebrain, midbrain and hindbrain cells. |
| Links |
PubMed Online version:10.1038/nn854 |
| Keywords |
Animals; Brain/embryology; Cell Differentiation/physiology; Chick Embryo/cytology; Chick Embryo/physiology; Culture Techniques; Fibroblast Growth Factors/physiology; Gastrula/metabolism; Mesoderm/physiology; Neurons/cytology; Protein Isoforms/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins/physiology; Signal Transduction/physiology; Wnt Proteins; Zebrafish Proteins |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0045944: positive regulation of transcription from RNA polymerase II promoter |
ECO:0000316: |
UniProtKB:Q2LMP1
|
P |
Figure 2 B Shows that both Wnt3A and FGF8 together induce the expression of wnt8c in stage 4 rostral forebrain cells. The method they used was RT-PCR. |
complete | |||
| GO:0045944: positive regulation of transcription from RNA polymerase II promoter |
ECO:0000316: |
UniProtKB:Q90722
|
P |
Figure 2 B Shows that both Wnt3A and FGF8 together induce the expression of wnt8c in stage 4 rostral forebrain cells. The method they used was RT-PCR. |
complete | |||
Notes
See also
References
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