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CHICK:FGF8
Contents
| Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
| Gene Name(s) | FGF8 | |
| Protein Name(s) | Fibroblast growth factor 8
FGF-8 Heparin-binding growth factor 8 HBGF-8 | |
| External Links | ||
| UniProt | Q90722 | |
| EMBL | U55189 | |
| RefSeq | NP_001012785.1 | |
| UniGene | Gga.661 | |
| ProteinModelPortal | Q90722 | |
| SMR | Q90722 | |
| STRING | 9031.ENSGALP00000038573 | |
| PaxDb | Q90722 | |
| PRIDE | Q90722 | |
| GeneID | 396313 | |
| KEGG | gga:396313 | |
| CTD | 2253 | |
| eggNOG | NOG327940 | |
| HOGENOM | HOG000115986 | |
| HOVERGEN | HBG005659 | |
| InParanoid | Q90722 | |
| KO | K04358 | |
| PhylomeDB | Q90722 | |
| NextBio | 20816361 | |
| PRO | PR:Q90722 | |
| Proteomes | UP000000539 | |
| GO | GO:0005576 GO:0051216 GO:0030154 GO:0042733 GO:0030326 GO:0009880 GO:0060684 GO:0008543 GO:0060174 GO:0060173 GO:0051781 GO:0010628 GO:0045893 GO:0030177 GO:0010468 GO:0071774 | |
| InterPro | IPR008996 IPR028249 IPR002209 IPR028142 | |
| PANTHER | PTHR11486 PTHR11486:SF3 | |
| PRINTS | PR00262 | |
| SMART | SM00442 | |
| SUPFAM | SSF50353 | |
| PROSITE | PS00247 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
ECO:0000316 |
|
P |
Figure 2 B Shows that both Wnt3A and FGF8 together induce the expression of wnt8c in stage 4 rostral forebrain cells. The method they used was RT-PCR. |
complete | ||||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030177 |
positive regulation of Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060684 |
epithelial-mesenchymal cell signaling |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060173 |
limb development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009880 |
embryonic pattern specification |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005104 |
fibroblast growth factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071774 |
response to fibroblast growth factor |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042733 |
embryonic digit morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030326 |
embryonic limb morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060174 |
limb bud formation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051781 |
positive regulation of cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Nordström, U et al. (2002) Progressive induction of caudal neural character by graded Wnt signaling. Nat. Neurosci. 5 525-32 PubMed GONUTS page
- ↑ 2.0 2.1 Kengaku, M et al. (1998) Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 280 1274-7 PubMed GONUTS page
- ↑ 3.0 3.1 Kawakami, Y et al. (2001) WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Cell 104 891-900 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Ohuchi, H et al. (1997) The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development 124 2235-44 PubMed GONUTS page
- ↑ Brent, AE & Tabin, CJ (2004) FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development 131 3885-96 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Zhou, J et al. (2007) IHH and FGF8 coregulate elongation of digit primordia. Biochem. Biophys. Res. Commun. 363 513-8 PubMed GONUTS page
- ↑ 7.0 7.1 Vogel, A et al. (1996) Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122 1737-50 PubMed GONUTS page
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- Phasianidae
- Phasianinae
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0010628 ! positive regulation of gene expression
- GO:0030177 ! positive regulation of Wnt signaling pathway
- GO:0051781 ! positive regulation of cell division
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