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DANRE:Q4ZJE9

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) jun (ECO:0000313 with ZFIN:ZDB-GENE-030131-7859)
Protein Name(s) C-Jun (ECO:0000313 with EMBL:AAY21257.1)
External Links
UniProt Q4ZJE9
EMBL DQ003340
UniGene Dr.1064
ProteinModelPortal Q4ZJE9
SMR Q4ZJE9
STRING 7955.ENSDARP00000063911
PaxDb Q4ZJE9
ZFIN ZDB-GENE-030131-7859
eggNOG KOG0837
ENOG410XRWH
HOGENOM HOG000006648
HOVERGEN HBG001722
GO GO:0000790
GO:0005667
GO:0000978
GO:0000981
GO:0003713
GO:0008134
GO:0060070
GO:0032870
GO:0000122
GO:0045597
GO:0045944
GO:0051726
GO:0010941
GO:0042127
GO:0046686
GO:0051591
GO:0034097
GO:0042493
GO:0032496
GO:0009612
GO:0051597
GO:0009314
GO:0006351
Gene3D 1.10.880.10
InterPro IPR004827
IPR015558
IPR005643
IPR002112
IPR008917
PANTHER PTHR11462:SF8
Pfam PF00170
PF03957
PRINTS PR00043
SMART SM00338
SUPFAM SSF47454
PROSITE PS50217
PS00036

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894784

P

Seeded From UniProt

GO:0000790

nuclear chromatin

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894784

C

Seeded From UniProt

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894784

F

Seeded From UniProt

GO:0000981

RNA polymerase II transcription factor activity, sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894784

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002112
InterPro:IPR008917
InterPro:IPR015558

F

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002112
InterPro:IPR004827
InterPro:IPR015558

F

Seeded From UniProt

GO:0003713

transcription coactivator activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

F

Seeded From UniProt

GO:0005667

transcription factor complex

PMID:18347071[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080908-1

C

Seeded From UniProt

GO:0006351

transcription, DNA-templated

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002112
InterPro:IPR004827
InterPro:IPR008917
InterPro:IPR015558

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

GO:0008134

transcription factor binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

F

Seeded From UniProt

GO:0009314

response to radiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0009612

response to mechanical stimulus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0010941

regulation of cell death

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0032496

response to lipopolysaccharide

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0032870

cellular response to hormone stimulus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0034097

response to cytokine

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0042127

regulation of cell proliferation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0042493

response to drug

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004827

F

Seeded From UniProt

GO:0045597

positive regulation of cell differentiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894784

P

Seeded From UniProt

GO:0046686

response to cadmium ion

PMID:16799861[2]

IEP: Inferred from Expression Pattern

-

P

Seeded From UniProt

GO:0051591

response to cAMP

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0051597

response to methylmercury

PMID:15984772[3]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0051726

regulation of cell cycle

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000894785

P

Seeded From UniProt

GO:0060070

canonical Wnt signaling pathway

PMID:18347071[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080908-1

P

Seeded From UniProt

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:18347071[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080908-1

F

Seeded From UniProt

GO:0008013

beta-catenin binding

PMID:18347071[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080908-1

F

Seeded From UniProt

GO:0022004

midbrain-hindbrain boundary maturation during brain development

PMID:27050765[4]

IMP: Inferred from Mutant Phenotype

P

Loss of c-Jun rescued the deformed brain induced by trim69 knockdown shown in figure

complete

GO:0022004

midbrain-hindbrain boundary maturation during brain development

PMID:27050765[4]

IMP: Inferred from Mutant Phenotype

P

Loss of c-Jun rescued the deformed brain induced by trim69 knockdown shown in figure 7

complete
CACAO 11710

GO:0072089

stem cell proliferation

PMID:27050765[4]

IDA: Inferred from Direct Assay

P

qPCR showed the expression for stem cell markers can be rescued by co-injection with c-Jun-MO and this match with the in situ hybridization shown in figure 3

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gan, XQ et al. (2008) Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J. Cell Biol. 180 1087-100 PubMed GONUTS page
  2. Gonzalez, P et al. (2006) Comparative effects of direct cadmium contamination on gene expression in gills, liver, skeletal muscles and brain of the zebrafish (Danio rerio). Biometals 19 225-35 PubMed GONUTS page
  3. Gonzalez, P et al. (2005) Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Environ. Sci. Technol. 39 3972-80 PubMed GONUTS page
  4. 4.0 4.1 4.2 Han, R et al. (2016) Trim69 regulates zebrafish brain development by ap-1 pathway. Sci Rep 6 24034 PubMed GONUTS page