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HUMAN:WNT9A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WNT9A (synonyms: WNT14)
Protein Name(s) Protein Wnt-9a

Protein Wnt-14

External Links
UniProt O14904
EMBL AB060283
AL360269
CH471098
BC111960
BC113431
AF028702
CCDS CCDS31045.1
RefSeq NP_003386.1
UniGene Hs.149504
ProteinModelPortal O14904
SMR O14904
STRING 9606.ENSP00000272164
PaxDb O14904
PRIDE O14904
DNASU 7483
Ensembl ENST00000272164
GeneID 7483
KEGG hsa:7483
UCSC uc001hri.2
CTD 7483
GeneCards GC01M228106
HGNC HGNC:12778
HPA HPA011223
MIM 602863
neXtProt NX_O14904
PharmGKB PA37379
eggNOG NOG291879
GeneTree ENSGT00690000101857
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid O14904
KO K01064
OMA VECKQCT
OrthoDB EOG7G7KP9
PhylomeDB O14904
TreeFam TF105310
Reactome REACT_163710
REACT_18372
REACT_200643
ChiTaRS WNT9A
GeneWiki WNT9A
GenomeRNAi 7483
NextBio 29314
PRO PR:O14904
Proteomes UP000005640
Bgee O14904
CleanEx HS_WNT9A
ExpressionAtlas O14904
Genevestigator O14904
GO GO:0005576
GO:0005615
GO:0070062
GO:0005578
GO:0005109
GO:0060070
GO:0045165
GO:0007267
GO:0071300
GO:0061303
GO:0035115
GO:0072498
GO:0048704
GO:0061072
GO:0007093
GO:0007275
GO:0008285
GO:0032331
GO:0043154
GO:0030182
GO:0045597
GO:0045880
GO:0016055
InterPro IPR005817
IPR013303
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01894
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0048018

receptor ligand activity

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:28733458[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072498

embryonic skeletal joint development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O42280

P

Seeded From UniProt

complete

involved_in

GO:0061303

cornea development in camera-type eye

PMID:16258938[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O42280

P

Seeded From UniProt

complete

involved_in

GO:0061072

iris morphogenesis

PMID:16258938[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O42280

P

Seeded From UniProt

complete

involved_in

GO:0032331

negative regulation of chondrocyte differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O42280

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:17351820[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

PMID:17351820[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071300

cellular response to retinoic acid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:9441749[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

PMID:9441749[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:9441749[4]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

involved_in

GO:0061037

negative regulation of cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0048856

anatomical structure development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0048704

embryonic skeletal system morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0045880

positive regulation of smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0045597

positive regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0035115

embryonic forelimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

involved_in

GO:0032331

negative regulation of chondrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R5M2
ensembl:ENSMUSP00000104411

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013303

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013303

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013303

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR013303

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

Reactome:R-HSA-195721

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-3247843

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
  2. ↑ 2.0 2.1 Fokina, VM & Frolova, EI (2006) Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Dev. Dyn. 235 496-505 PubMed GONUTS page
  3. ↑ 3.0 3.1 Xiang, Y et al. (2008) Knocking down Wnt9a mRNA levels increases cellular proliferation. Mol. Biol. Rep. 35 73-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Bergstein, I et al. (1997) Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. Genomics 46 450-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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