MOUSE:LRP5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lrp5 (synonyms: Lrp7)
Protein Name(s)	Low-density lipoprotein receptor-related protein 5 LRP-5 Low-density lipoprotein receptor-related protein 7 LRP-7 Lr3
External Links
UniProt	Q91VN0
EMBL	AF064984 AF077847 AC112990 AC117797 BC011374
CCDS	CCDS37881.1
RefSeq	NP_032539.2
UniGene	Mm.274581
ProteinModelPortal	Q91VN0
SMR	Q91VN0
BioGrid	201202
IntAct	Q91VN0
MINT	MINT-8293473
PhosphoSite	Q91VN0
PaxDb	Q91VN0
PRIDE	Q91VN0
Ensembl	ENSMUST00000025856
GeneID	16973
KEGG	mmu:16973
UCSC	uc008fwq.2
CTD	4041
MGI	MGI:1278315
eggNOG	NOG121718
GeneTree	ENSGT00760000118968
HOVERGEN	HBG049167
InParanoid	Q91VN0
KO	K03068
OMA	LFWTCEA
OrthoDB	EOG75XGK3
TreeFam	TF315253
Reactome	REACT_216784 REACT_262115
NextBio	291030
PRO	PR:Q91VN0
Proteomes	UP000000589
Bgee	Q91VN0
ExpressionAtlas	Q91VN0
Genevestigator	Q91VN0
GO	GO:0005783 GO:0016021 GO:0005739 GO:0005886 GO:0043235 GO:0015026 GO:0042813 GO:0017147 GO:0060612 GO:0060033 GO:0009952 GO:1902262 GO:0060348 GO:0048539 GO:0060349 GO:0046849 GO:0060444 GO:0060070 GO:0042074 GO:0060764 GO:0042632 GO:0008203 GO:0048596 GO:0042733 GO:0060059 GO:0006897 GO:0035426 GO:0001702 GO:0006007 GO:0035108 GO:0060603 GO:0045668 GO:0071901 GO:0002076 GO:0045600 GO:0002053 GO:0045840 GO:0033690 GO:0051091 GO:0045944 GO:0045893 GO:0042981 GO:0008217 GO:0046850 GO:0060828 GO:0045598 GO:0061178 GO:0030278 GO:0043434 GO:0061299 GO:0061304 GO:0035019 GO:0001944 GO:0016055 GO:0044332
Gene3D	2.120.10.30 4.10.400.10
InterPro	IPR011042 IPR000742 IPR023415 IPR000033 IPR002172 IPR017049
Pfam	PF00057 PF00058
PIRSF	PIRSF036314
PRINTS	PR00261
SMART	SM00181 SM00192 SM00135
SUPFAM	SSF57424
PROSITE	PS01209 PS50068 PS51120

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0061304	retinal blood vessel morphogenesis	PMID:27031698^[1]	ECO:0000315			P		Figure 1 shows loss of Lrp5 causes retinal hypovascularization and neovascularization in all stages of mouse development. Figure 5 also shows restoring Lrp5 in endothelial cells rescues retinal vascular defect.	complete CACAO 11809
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:26891291^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering	PMID:18957220^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	PMID:17700537^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0110135	Norrin signaling pathway	PMID:15035989^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:15035989^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15035989^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035426	extracellular matrix-cell signaling	PMID:15035989^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	PMID:17700537^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061304	retinal blood vessel morphogenesis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0060444	branching involved in mammary gland duct morphogenesis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248 UniProtKB:O75197 ZFIN:ZDB-GENE-050518-2	P		Seeded From UniProt	complete
involved_in	GO:0048539	bone marrow development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056261 UniProtKB:O75197	C		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248	F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000056265 UniProtKB:O75197	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000119 MGI:MGI:1278315 PANTHER:PTN000056248 UniProtKB:O75197	F		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95290 PANTHER:PTN000056261 UniProtKB:O75197	C		Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1278315 PANTHER:PTN000056265	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902262	apoptotic process involved in blood vessel morphogenesis	PMID:16163358^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279	P	occurs_in:(EMAPA:16198)\|occurs_in:(EMAPA:35198)	Seeded From UniProt	complete
enables	GO:0071936	coreceptor activity involved in Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071901	negative regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061304	retinal blood vessel morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061299	retina vasculature morphogenesis in camera-type eye	PMID:19837032^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102570 MGI:MGI:108520	P	has_participant:(EMAPA:36520)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061299	retina vasculature morphogenesis in camera-type eye	PMID:18263894^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279 MGI:MGI:3774282	P	has_participant:(EMAPA:36520)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061299	retina vasculature morphogenesis in camera-type eye	PMID:11956231^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279	P	has_participant:(EMAPA:36520)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:12509515^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448955	P	regulates_o_occurs_in:(EMAPA:32927) regulates_o_occurs_in:(CL:0000169)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060764	cell-cell signaling involved in mammary gland development	PMID:16973609^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3663738	P	has_participant:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060612	adipose tissue development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060603	mammary gland duct morphogenesis	PMID:19503830^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060444	branching involved in mammary gland duct morphogenesis	PMID:16973609^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3663738	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060349	bone morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15923619^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:98961	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16973609^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3663738	P	occurs_in:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15143170^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:11956231^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060042	retina morphogenesis in camera-type eye	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060033	anatomical structure regression	PMID:16163358^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279	P	has_participant:(EMAPA:16198)\|has_participant:(EMAPA:35198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048539	bone marrow development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:19041748^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96274 MGI:MGI:98796	P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:15537447^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:17627087^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:17147489^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3530598	P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:16790443^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3612485	P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:15207752^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:12817748^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:11956231^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:11956231^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279	P	occurs_in:(EMAPA:36520)	Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:11956231^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:15142971^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P	has_participant:(EMAPA:17428)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042632	cholesterol homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042074	cell migration involved in gastrulation	PMID:15142971^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P	occurs_in:(EMAPA:16072) results_in_movement_of:(CL:0000222)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035108	limb morphogenesis	PMID:15537447^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P	has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:19672307^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3663738	P	occurs_in:(EMAPA:17760)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033690	positive regulation of osteoblast proliferation	PMID:11956231^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:11956231^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04426 UniProtKB:P22724	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15142971^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008217	regulation of blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008203	cholesterol metabolic process	PMID:12509515^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448955	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006007	glucose catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[25]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:16790443^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3612485	P	occurs_in:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75197	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001944	vasculature development	PMID:16163358^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183279	P	results_in_development_of:(EMAPA:16198)\|results_in_development_of:(EMAPA:35198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:15142971^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298218	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD0 ensembl:ENSRNOP00000022213	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD0 ensembl:ENSRNOP00000022213	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017049	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017049	F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017049	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Huang, W et al. (2016) Critical Endothelial Regulation by LRP5 during Retinal Vascular Development. PLoS ONE 11 e0152833 PubMed GONUTS page
↑ Sun, T et al. (2016) MiR-9-5p, miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation, Differentiation, and Adhesion. Int J Mol Sci 17 236 PubMed GONUTS page
↑ Zhang, B et al. (2008) LRP4 serves as a coreceptor of agrin. Neuron 60 285-97 PubMed GONUTS page
↑ ^4.0 ^4.1 Li, ZG et al. (2008) Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene 27 596-603 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lobov, IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437 417-21 PubMed GONUTS page
↑ Ye, X et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139 285-98 PubMed GONUTS page
↑ Xia, CH et al. (2008) A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum. Mol. Genet. 17 1605-12 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Kato, M et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157 303-14 PubMed GONUTS page
↑ ^11.0 ^11.1 Fujino, T et al. (2003) Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc. Natl. Acad. Sci. U.S.A. 100 229-34 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Lindvall, C et al. (2006) The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J. Biol. Chem. 281 35081-7 PubMed GONUTS page
↑ Lindvall, C et al. (2009) The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS ONE 4 e5813 PubMed GONUTS page
↑ Wang, Z et al. (2005) Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol. Cell. Biol. 25 5022-30 PubMed GONUTS page
↑ González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page
↑ Yadav, VK et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135 825-37 PubMed GONUTS page
↑ ^17.0 ^17.1 Holmen, SL et al. (2004) Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J. Bone Miner. Res. 19 2033-40 PubMed GONUTS page
↑ Dubrow, SA et al. () Gender specific LRP5 influences on trabecular bone structure and strength. J Musculoskelet Neuronal Interact 7 166-73 PubMed GONUTS page
↑ Iwaniec, UT et al. (2007) PTH stimulates bone formation in mice deficient in Lrp5. J. Bone Miner. Res. 22 394-402 PubMed GONUTS page
↑ ^20.0 ^20.1 Sawakami, K et al. (2006) The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J. Biol. Chem. 281 23698-711 PubMed GONUTS page
↑ Akhter, MP et al. (2004) Bone biomechanical properties in LRP5 mutant mice. Bone 35 162-9 PubMed GONUTS page
↑ Babij, P et al. (2003) High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner. Res. 18 960-74 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Kelly, OG et al. (2004) The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development 131 2803-15 PubMed GONUTS page
↑ Badders, NM et al. (2009) The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS ONE 4 e6594 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:27031698-1] Huang, W et al. (2016) Critical Endothelial Regulation by LRP5 during Retinal Vascular Development. PLoS ONE 11 e0152833 PubMed GONUTS page

[PMID:26891291-2] Sun, T et al. (2016) MiR-9-5p, miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation, Differentiation, and Adhesion. Int J Mol Sci 17 236 PubMed GONUTS page

[PMID:18957220-3] Zhang, B et al. (2008) LRP4 serves as a coreceptor of agrin. Neuron 60 285-97 PubMed GONUTS page

[PMID:17700537-4] 4.0 ^4.1 Li, ZG et al. (2008) Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone. Oncogene 27 596-603 PubMed GONUTS page

[PMID:15035989-5] 5.0 ^5.1 ^5.2 ^5.3 Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16163358-7] 7.0 ^7.1 ^7.2 Lobov, IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437 417-21 PubMed GONUTS page

[PMID:19837032-8] Ye, X et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139 285-98 PubMed GONUTS page

[PMID:18263894-9] Xia, CH et al. (2008) A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum. Mol. Genet. 17 1605-12 PubMed GONUTS page

[PMID:11956231-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Kato, M et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157 303-14 PubMed GONUTS page

[PMID:12509515-11] 11.0 ^11.1 Fujino, T et al. (2003) Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc. Natl. Acad. Sci. U.S.A. 100 229-34 PubMed GONUTS page

[PMID:16973609-12] 12.0 ^12.1 ^12.2 Lindvall, C et al. (2006) The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J. Biol. Chem. 281 35081-7 PubMed GONUTS page

[PMID:19503830-13] Lindvall, C et al. (2009) The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS ONE 4 e5813 PubMed GONUTS page

[PMID:15923619-14] Wang, Z et al. (2005) Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol. Cell. Biol. 25 5022-30 PubMed GONUTS page

[PMID:15143170-15] González-Sancho, JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol. Cell. Biol. 24 4757-68 PubMed GONUTS page

[PMID:19041748-16] Yadav, VK et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135 825-37 PubMed GONUTS page

[PMID:15537447-17] 17.0 ^17.1 Holmen, SL et al. (2004) Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J. Bone Miner. Res. 19 2033-40 PubMed GONUTS page

[PMID:17627087-18] Dubrow, SA et al. () Gender specific LRP5 influences on trabecular bone structure and strength. J Musculoskelet Neuronal Interact 7 166-73 PubMed GONUTS page

[PMID:17147489-19] Iwaniec, UT et al. (2007) PTH stimulates bone formation in mice deficient in Lrp5. J. Bone Miner. Res. 22 394-402 PubMed GONUTS page

[PMID:16790443-20] 20.0 ^20.1 Sawakami, K et al. (2006) The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J. Biol. Chem. 281 23698-711 PubMed GONUTS page

[PMID:15207752-21] Akhter, MP et al. (2004) Bone biomechanical properties in LRP5 mutant mice. Bone 35 162-9 PubMed GONUTS page

[PMID:12817748-22] Babij, P et al. (2003) High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner. Res. 18 960-74 PubMed GONUTS page

[PMID:15142971-23] 23.0 ^23.1 ^23.2 ^23.3 Kelly, OG et al. (2004) The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development 131 2803-15 PubMed GONUTS page

[PMID:19672307-24] Badders, NM et al. (2009) The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS ONE 4 e6594 PubMed GONUTS page

[PMID:14651853-25] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

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