MOUSE:APC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Apc
Protein Name(s)	Adenomatous polyposis coli protein Protein APC mAPC
External Links
UniProt	Q61315
EMBL	M88127 U02937
PIR	I49505
UniGene	Mm.384171
PDB	1VJ6
PDBsum	1VJ6
ProteinModelPortal	Q61315
SMR	Q61315
IntAct	Q61315
PhosphoSite	Q61315
MaxQB	Q61315
PaxDb	Q61315
PRIDE	Q61315
MGI	MGI:88039
eggNOG	NOG259696
HOGENOM	HOG000033986
HOVERGEN	HBG004264
InParanoid	Q61315
PhylomeDB	Q61315
ChiTaRS	Apc
EvolutionaryTrace	Q61315
PRO	PR:Q61315
Proteomes	UP000000589
CleanEx	MM_APC
Genevestigator	Q61315
GO	GO:0005912 GO:0030424 GO:0044295 GO:0030877 GO:0042995 GO:0031253 GO:0005813 GO:0005737 GO:0030426 GO:0000776 GO:0030027 GO:0005874 GO:0005634 GO:0005886 GO:0032587 GO:0034750 GO:0008013 GO:0008017 GO:0051010 GO:0002020 GO:0019887 GO:0009952 GO:0009798 GO:0007409 GO:0060070 GO:0044336 GO:0044337 GO:0007050 GO:0016477 GO:0006974 GO:0051276 GO:0031122 GO:0009953 GO:0001942 GO:0001822 GO:0007091 GO:0000281 GO:0046716 GO:0043066 GO:0090090 GO:0008285 GO:0045736 GO:0050680 GO:0060770 GO:0043409 GO:0007026 GO:0042483 GO:0030178 GO:0007389 GO:0043065 GO:0045785 GO:0045597 GO:0051781 GO:0030335 GO:0030858 GO:0031116 GO:0045732 GO:0006461 GO:0009954 GO:0051988 GO:0051726 GO:0045595 GO:0030334 GO:0030856 GO:0032886 GO:0051171 GO:0045667 GO:0045670 GO:0060041 GO:0043588 GO:0035019 GO:0019827 GO:0033077 GO:0048538 GO:0016055
Gene3D	1.25.10.10
InterPro	IPR026836 IPR009240 IPR009234 IPR009223 IPR026831 IPR026818 IPR011989 IPR016024 IPR000225 IPR009232 IPR009224
PANTHER	PTHR12607 PTHR12607:SF11
Pfam	PF05972 PF05956 PF05923 PF00514 PF05937 PF05924 PF11414
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26948948^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:28057765^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9WV60	F		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:28057765^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8C0M8	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28057765^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0011108)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28057765^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0011108)	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:28057765^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0011108)	Seeded From UniProt	complete
involved_in	GO:1904781	positive regulation of protein localization to centrosome	PMID:28057765^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0011108) has_regulation_target:(UniProtKB:Q8C0M8) has_regulation_target:(UniProtKB:Q9ERR1)	Seeded From UniProt	complete
part_of	GO:0034750	Scrib-APC-beta-catenin complex	PMID:16611247^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:18281465^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B2RUR8	F		Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0032886	regulation of microtubule-based process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
enables	GO:0019887	protein kinase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
colocalizes_with	GO:0005913	cell-cell adherens junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996 UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612	P		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288612 UniProtKB:P25054	F		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 PANTHER:PTN000288612 UniProtKB:P25054	C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996 UniProtKB:P25054 WB:WBGene00000156	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996	C		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288612 WB:WBGene00000156	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000211	regulation of glutamate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904781	positive regulation of protein localization to centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:15563600^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521822	P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:15198980^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	regulates_o_occurs_in:(EMAPA:32873)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11756652^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	regulates_o_occurs_in:(EMAPA:16169) regulates_o_occurs_in:(CL:0000008)\|regulates_o_occurs_in:(EMAPA:16182) regulates_o_occurs_in:(CL:0000011)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0070852	cell body fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065003	protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	PMID:17363566^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966,MGI:MGI:2385927	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16887818^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	occurs_in:(EMAPA:16050)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060041	retina development in camera-type eye	PMID:10982921^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	results_in_development_of:(EMAPA:17172)\|results_in_development_of:(EMAPA:17172)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:17227893^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051781	positive regulation of cell division	PMID:16950562^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:35778) regulates_o_results_in_division_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	PMID:8988060^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051276	chromosome organization	PMID:17200209^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98834	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051276	chromosome organization	PMID:17200209^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051171	regulation of nitrogen compound metabolic process	PMID:16740478^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521822	P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	PMID:18716223^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:9037065^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1857932	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:14758356^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101884	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:10451698^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:9060821^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:17002498^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3688435	P	results_in_development_of:(EMAPA:18768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:16025118^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589207	P	results_in_development_of:(EMAPA:18768)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:18076571^[24]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046716	muscle cell cellular homeostasis	PMID:18056981^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96559	P	occurs_in:(EMAPA:32716)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	PMID:16368433^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:32764) regulates_o_has_participant:(CL:0000584)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	PMID:16478791^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045670	regulation of osteoclast differentiation	PMID:15802266^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	occurs_in:(EMAPA:19143) regulates_o_results_in_acquisition_of_features_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045667	regulation of osteoblast differentiation	PMID:15802266^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	occurs_in:(EMAPA:19143) regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:16709231^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	occurs_in:(EMAPA:35402)\|occurs_in:(EMAPA:17972)\|occurs_in:(EMAPA:17962)\|occurs_in:(EMAPA:32834)\|occurs_in:(EMAPA:18248)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:15198980^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	occurs_in:(EMAPA:32873)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045595	regulation of cell differentiation	PMID:17377531^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97250	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
colocalizes_with	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process	PMID:17377531^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	PMID:17377531^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97250	P		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	PMID:18716223^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:9453487^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	results_in_development_of:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043409	negative regulation of MAPK cascade	PMID:16478791^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043409	negative regulation of MAPK cascade	PMID:16478791^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:16950562^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:35778) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:11756652^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	regulates_o_occurs_in:(EMAPA:16182) regulates_o_occurs_in:(CL:0000011)\|regulates_o_occurs_in:(EMAPA:16169) regulates_o_occurs_in:(CL:0000008)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:17227893^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
colocalizes_with	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:16525027^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042483	negative regulation of odontogenesis	PMID:17002498^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3688435	P	regulates_o_results_in_formation_of:(EMAPA:16262)	Seeded From UniProt	complete
colocalizes_with	GO:0035371	microtubule plus-end	PMID:18716223^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:1541640^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:1541640^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:16025118^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589207	P	occurs_in:(EMAPA:18768)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032886	regulation of microtubule-based process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18076571^[24]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031274	positive regulation of pseudopodium assembly	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0031253	cell projection membrane	PMID:16621792^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031122	cytoplasmic microtubule organization	PMID:18716223^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031116	positive regulation of microtubule polymerization	PMID:16525027^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030856	regulation of epithelial cell differentiation	PMID:9771477^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	occurs_in:(EMAPA:35266) regulates_o_results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:15207235^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16668) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15207235^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16668) part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	PMID:17192415^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_results_in_movement_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:17377531^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97250	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:9371501^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:32874) regulates_o_results_in_movement_of:(CL:0000584)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:18644872^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1333813	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:17363566^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966,MGI:MGI:2385927	P	regulates_o_occurs_in:(EMAPA:32290) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:16887818^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:16050)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:16740478^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521822	P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:15563600^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521822	P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:15550389^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	regulates_o_occurs_in:(EMAPA:36524) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:15198980^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	regulates_o_occurs_in:(EMAPA:32873)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030178	negative regulation of Wnt signaling pathway	PMID:11756652^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	regulates_o_occurs_in:(EMAPA:16182) regulates_o_occurs_in:(CL:0000011)\|regulates_o_occurs_in:(EMAPA:16169) regulates_o_occurs_in:(CL:0000008)	Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
enables	GO:0019887	protein kinase regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:18725524^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:15198980^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	occurs_in:(EMAPA:32873)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:12645927^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449944	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:10346819^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:16887818^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:12645927^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449944	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:12645927^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449944	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009798	axis specification	PMID:12645927^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449944	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9515784^[44]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104288	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9506519^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894293	P	regulates_o_occurs_in:(EMAPA:19252)\|regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9288104^[46]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9159163^[47]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:8978063^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:8978062^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:8945508^[50]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97798	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18719115^[51]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95891	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18656477^[52]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95294 MGI:MGI:99439	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18644872^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1333813	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18485889^[53]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1927593	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18464259^[54]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109392	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18258607^[55]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97608	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18056981^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96559	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17989230^[56]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88274	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17956267^[57]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97595	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17893885^[58]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97611	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17875695^[59]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103298	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17681179^[60]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106923	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17671182^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1342287	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17615359^[62]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108005	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17596282^[63]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97250	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17377531^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97250	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17371273^[64]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98233	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17299058^[65]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98373	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16478791^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96224	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16007074^[66]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96646	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15958588^[67]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98233	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15684064^[68]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346834	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15380519^[69]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101884	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11809702^[70]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894293 MGI:MGI:97798	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11773073^[71]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1914186	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11731407^[72]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97361	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11606502^[73]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97361	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11533709^[74]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97794	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11385109^[75]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95294	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11381263^[76]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109558	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11274413^[77]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11245490^[78]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97798	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11197776^[79]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894293	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10987272^[80]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97797 MGI:MGI:97798	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10969066^[81]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1195256	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10919675^[82]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642 MGI:MGI:94912	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10783317^[83]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97798	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10716720^[84]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104642 MGI:MGI:98834	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10708962^[85]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894293	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10626800^[86]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894293	P	regulates_o_occurs_in:(EMAPA:17021)\|regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9927046^[87]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9865728^[88]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	regulates_o_occurs_in:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9135000^[89]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:35266)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:8945508^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857957	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:7954428^[90]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18656477^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17596282^[63]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16638711^[91]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15563600^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521822	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15550389^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15198980^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	regulates_o_occurs_in:(EMAPA:32873)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:12370429^[92]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11559569^[93]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11478486^[94]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:35180)\|regulates_o_occurs_in:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11309311^[95]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10535960^[96]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10506110^[97]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	regulates_o_occurs_in:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10334197^[98]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:12874278^[99]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:10346819^[43]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:18716223^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:18716223^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:15207235^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16668) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:16740478^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521822	P	occurs_in:(EMAPA:18306)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007163	establishment or maintenance of cell polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007094	mitotic spindle assembly checkpoint	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	PMID:15767571^[100]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1333889	P	occurs_in:(EMAPA:32834) occurs_in:(CL:0000066)\|occurs_in:(CL:0000037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	PMID:16025118^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589207	P	occurs_in:(EMAPA:18768) occurs_in:(CL:0002420)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	PMID:15767571^[100]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	occurs_in:(CL:0000037)\|occurs_in:(EMAPA:32834) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007026	negative regulation of microtubule depolymerization	PMID:16525027^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
colocalizes_with	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:16621792^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:16525027^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:8670282^[101]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10346819^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2123	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:17002498^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3688435	P	results_in_development_of:(EMAPA:35246)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:15550389^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857966	P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000281	mitotic cytokinesis	PMID:17893240^[102]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856318	P	occurs_in:(EMAPA:35777)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000281	mitotic cytokinesis	PMID:17570218^[103]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857951	P	occurs_in:(EMAPA:32873) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000281	mitotic cytokinesis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009240 InterPro:IPR026818 InterPro:IPR026836	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009234	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009223 InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009234 InterPro:IPR009240	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026818 InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:15314168^[104]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	negatively_regulates:(GO:0003674) negatively_regulates:(GO:0006366) negatively_regulates:(GO:0044093) negatively_regulates:(GO:0045944) negatively_regulates:(GO:0050673) negatively_regulates:(GO:0060070) positively_regulates:(GO:0002067)	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	PMID:15314168^[104]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	negatively_regulates:(GO:0003674) negatively_regulates:(GO:0006366) negatively_regulates:(GO:0044093) negatively_regulates:(GO:0045944) negatively_regulates:(GO:0050673) negatively_regulates:(GO:0060070) positively_regulates:(GO:0002067)	Seeded From UniProt	complete
involved_in	GO:0044092	negative regulation of molecular function	PMID:15314168^[104]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	negatively_regulates:(GO:0003674) negatively_regulates:(GO:0006366) negatively_regulates:(GO:0044093) negatively_regulates:(GO:0045944) negatively_regulates:(GO:0050673) negatively_regulates:(GO:0060070) positively_regulates:(GO:0002067)	Seeded From UniProt	complete
involved_in	GO:0030858	positive regulation of epithelial cell differentiation	PMID:15314168^[104]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	negatively_regulates:(GO:0003674) negatively_regulates:(GO:0006366) negatively_regulates:(GO:0044093) negatively_regulates:(GO:0045944) negatively_regulates:(GO:0050673) negatively_regulates:(GO:0060070) positively_regulates:(GO:0002067)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15314168^[104]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	negatively_regulates:(GO:0003674) negatively_regulates:(GO:0006366) negatively_regulates:(GO:0044093) negatively_regulates:(GO:0045944) negatively_regulates:(GO:0050673) negatively_regulates:(GO:0060070) positively_regulates:(GO:0002067)	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0301	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Liu, Z et al. (2016) Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Mol. Cell. Endocrinol. 427 57-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gao, FJ et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol. Biol. Cell 28 587-599 PubMed GONUTS page
↑ Takizawa, S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 11 453-64 PubMed GONUTS page
↑ Tran, H et al. (2008) Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22 528-42 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Colnot, S et al. (2004) Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc. Natl. Acad. Sci. U.S.A. 101 17216-21 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Sansom, OJ et al. (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18 1385-90 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hasegawa, S et al. (2002) Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc. Natl. Acad. Sci. U.S.A. 99 297-302 PubMed GONUTS page
↑ ^9.0 ^9.1 Bruxvoort, KJ et al. (2007) Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Res. 67 2490-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Chazaud, C & Rossant, J (2006) Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development 133 3379-87 PubMed GONUTS page
↑ Marcus, DM et al. (2000) Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption. Mol. Vis. 6 169-77 PubMed GONUTS page
↑ ^12.0 ^12.1 Dikovskaya, D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J. Cell Biol. 176 183-95 PubMed GONUTS page
↑ ^13.0 ^13.1 Hu, Y et al. (2007) Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac. Cancer Lett. 248 234-44 PubMed GONUTS page
↑ Zhang, T et al. (1997) Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res. 57 169-75 PubMed GONUTS page
↑ ^15.0 ^15.1 Alberici, P et al. (2007) Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am. J. Pathol. 170 377-87 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Benhamouche, S et al. (2006) Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev. Cell 10 759-70 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Purro, SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J. Neurosci. 28 8644-54 PubMed GONUTS page
↑ Wilson, CL et al. (1997) Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc. Natl. Acad. Sci. U.S.A. 94 1402-7 PubMed GONUTS page
↑ Gupta, RA et al. (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat. Med. 10 245-7 PubMed GONUTS page
↑ van der Houven van Oordt, CW et al. (1999) The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. Genes Chromosomes Cancer 24 191-8 PubMed GONUTS page
↑ Bjerknes, M et al. (1997) APC mutation and the crypt cycle in murine and human intestine. Am. J. Pathol. 150 833-9 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Kuraguchi, M et al. (2006) Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2 e146 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Gounari, F et al. (2005) Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat. Immunol. 6 800-9 PubMed GONUTS page
↑ ^24.0 ^24.1 Ohshima, R et al. (2007) Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells 12 1339-45 PubMed GONUTS page
↑ ^25.0 ^25.1 Baltgalvis, KA et al. (2008) Interleukin-6 and cachexia in ApcMin/+ mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 R393-401 PubMed GONUTS page
↑ Carothers, AM et al. (2006) Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. Exp. Cell Res. 312 387-400 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Park, KS et al. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J. Cell. Sci. 119 819-27 PubMed GONUTS page
↑ ^28.0 ^28.1 Holmen, SL et al. (2005) Essential role of beta-catenin in postnatal bone acquisition. J. Biol. Chem. 280 21162-8 PubMed GONUTS page
↑ You, S et al. (2006) Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol 87 227-36 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 Sansom, OJ et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446 676-9 PubMed GONUTS page
↑ Smits, R et al. (1998) Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114 275-83 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 Kita, K et al. (2006) Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol. Biol. Cell 17 2331-45 PubMed GONUTS page
↑ ^33.0 ^33.1 Moser, AR et al. (1992) The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J. Cell Biol. 116 1517-26 PubMed GONUTS page
↑ ^34.0 ^34.1 Sharma, M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J. Biol. Chem. 281 17140-9 PubMed GONUTS page
↑ Wasan, HS et al. (1998) APC in the regulation of intestinal crypt fission. J. Pathol. 185 246-55 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Zhou, FQ et al. (2004) NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 42 897-912 PubMed GONUTS page
↑ Kroboth, K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol. Biol. Cell 18 910-8 PubMed GONUTS page
↑ Mahmoud, NN et al. (1997) Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res. 57 5045-50 PubMed GONUTS page
↑ ^39.0 ^39.1 Phesse, TJ et al. (2008) Deficiency of Mbd2 attenuates Wnt signaling. Mol. Cell. Biol. 28 6094-103 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Qian, CN et al. (2005) Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J. Biol. Chem. 280 3938-45 PubMed GONUTS page
↑ Qian, Z et al. (2008) A critical role for Apc in hematopoietic stem and progenitor cell survival. J. Exp. Med. 205 2163-75 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 ^42.3 Ishikawa, TO et al. (2003) Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev. Biol. 253 230-46 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 Smits, R et al. (1999) Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 13 1309-21 PubMed GONUTS page
↑ Baker, SM et al. (1998) Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res. 58 1087-9 PubMed GONUTS page
↑ Takaku, K et al. (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92 645-56 PubMed GONUTS page
↑ Cormier, RT et al. (1997) Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat. Genet. 17 88-91 PubMed GONUTS page
↑ Gould, KA & Dove, WF (1997) Localized gene action controlling intestinal neoplasia in mice. Proc. Natl. Acad. Sci. U.S.A. 94 5848-53 PubMed GONUTS page
↑ Gould, KA et al. (1996) Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics 144 1777-85 PubMed GONUTS page
↑ Gould, KA et al. (1996) Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144 1769-76 PubMed GONUTS page
↑ ^50.0 ^50.1 Oshima, M et al. (1996) Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87 803-9 PubMed GONUTS page
↑ Yoshimizu, T et al. (2008) The H19 locus acts in vivo as a tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 105 12417-22 PubMed GONUTS page
↑ ^52.0 ^52.1 Dahlhoff, M et al. (2008) Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett. 582 2911-5 PubMed GONUTS page
↑ Elander, N et al. (2008) Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem. Biophys. Res. Commun. 372 249-53 PubMed GONUTS page
↑ Giroux, V et al. (2008) Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int. J. Cancer 123 303-11 PubMed GONUTS page
↑ Mutoh, M et al. (2008) Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Carcinogenesis 29 824-9 PubMed GONUTS page
↑ Shibata, H et al. (2007) Alpha-catenin is essential in intestinal adenoma formation. Proc. Natl. Acad. Sci. U.S.A. 104 18199-204 PubMed GONUTS page
↑ Leitges, M (2007) Functional PKC in vivo analysis using deficient mouse models. Biochem. Soc. Trans. 35 1018-20 PubMed GONUTS page
↑ Ploplis, VA et al. (2007) A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. J. Pathol. 213 266-74 PubMed GONUTS page
↑ Blanc, V et al. (2007) Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. Cancer Res. 67 8565-73 PubMed GONUTS page
↑ Li, P et al. (2007) Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology 133 599-607 PubMed GONUTS page
↑ Ghaleb, AM et al. (2007) Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 67 7147-54 PubMed GONUTS page
↑ Rakoff-Nahoum, S & Medzhitov, R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317 124-7 PubMed GONUTS page
↑ ^63.0 ^63.1 Strom, A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134 2719-25 PubMed GONUTS page
↑ Berger, FG et al. (2007) Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem. Soc. Trans. 35 336-9 PubMed GONUTS page
↑ Sansom, OJ et al. (2007) Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut 56 1410-4 PubMed GONUTS page
↑ Nateri, AS et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437 281-5 PubMed GONUTS page
↑ Tucker, JM et al. (2005) Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res. 65 5390-8 PubMed GONUTS page
↑ Schoonjans, K et al. (2005) Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc. Natl. Acad. Sci. U.S.A. 102 2058-62 PubMed GONUTS page
↑ Wang, D et al. (2004) Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6 285-95 PubMed GONUTS page
↑ Seno, H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 62 506-11 PubMed GONUTS page
↑ Dinchuk, JE et al. (2002) Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J. Biol. Chem. 277 12970-7 PubMed GONUTS page
↑ Ahn, B & Ohshima, H (2001) Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res. 61 8357-60 PubMed GONUTS page
↑ Scott, DJ et al. (2001) Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology 121 889-99 PubMed GONUTS page
↑ Sonoshita, M et al. (2001) Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat. Med. 7 1048-51 PubMed GONUTS page
↑ Stanton, JL & Green, DP (2001) Meta-analysis of gene expression in mouse preimplantation embryo development. Mol. Hum. Reprod. 7 545-52 PubMed GONUTS page
↑ Rudolph, KL et al. (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28 155-9 PubMed GONUTS page
↑ Hong, KH et al. (2001) Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 98 3935-9 PubMed GONUTS page
↑ Oshima, M et al. (2001) Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 61 1733-40 PubMed GONUTS page
↑ Taketo, MM & Takaku, K (2000) Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum. Cell 13 85-95 PubMed GONUTS page
↑ Chulada, PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 4705-8 PubMed GONUTS page
↑ Takaku, K et al. (2000) Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J. Biol. Chem. 275 34013-6 PubMed GONUTS page
↑ Cormier, RT & Dove, WF (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res. 60 3965-70 PubMed GONUTS page
↑ Sasai, H et al. (2000) Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis 21 953-8 PubMed GONUTS page
↑ Halberg, RB et al. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc. Natl. Acad. Sci. U.S.A. 97 3461-6 PubMed GONUTS page
↑ Taketo, MM & Takaku, K () Gastro-intestinal tumorigenesis in Smad4 mutant mice. Cytokine Growth Factor Rev. 11 147-57 PubMed GONUTS page
↑ Takaku, K et al. (1999) Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Cancer Res. 59 6113-7 PubMed GONUTS page
↑ Mahmoud, NN et al. (1999) Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res. 59 353-9 PubMed GONUTS page
↑ Yang, K et al. (1998) Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res. 58 5713-7 PubMed GONUTS page
↑ Oshima, H et al. (1997) Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice. Cancer Res. 57 1644-9 PubMed GONUTS page
↑ Levy, DB et al. (1994) Inactivation of both APC alleles in human and mouse tumors. Cancer Res. 54 5953-8 PubMed GONUTS page
↑ Ellender, M et al. (2006) In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia. Int. J. Radiat. Biol. 82 141-51 PubMed GONUTS page
↑ Girnun, GD et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc. Natl. Acad. Sci. U.S.A. 99 13771-6 PubMed GONUTS page
↑ Sohn, KJ et al. (2001) Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse. Cancer Res. 61 6912-7 PubMed GONUTS page
↑ Yu, CF et al. (2001) Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig. Dis. Sci. 46 1367-80 PubMed GONUTS page
↑ Moser, AR et al. (2001) Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice. Cancer Res. 61 3480-5 PubMed GONUTS page
↑ Novelli, MR et al. (1999) Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras. Proc. Natl. Acad. Sci. U.S.A. 96 12553-8 PubMed GONUTS page
↑ Pierre, F et al. (1999) T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement. Carcinogenesis 20 1953-6 PubMed GONUTS page
↑ Williamson, SL et al. (1999) Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. Carcinogenesis 20 805-10 PubMed GONUTS page
↑ Kanamori, M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J. Biol. Chem. 278 38758-64 PubMed GONUTS page
↑ ^100.0 ^100.1 Rao, CV et al. (2005) Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc. Natl. Acad. Sci. U.S.A. 102 4365-70 PubMed GONUTS page
↑ Senda, T et al. (1996) The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Biochem. Biophys. Res. Commun. 223 329-34 PubMed GONUTS page
↑ Caldwell, CM et al. (2007) APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J. Cell Biol. 178 1109-20 PubMed GONUTS page
↑ Abal, M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132 2448-58 PubMed GONUTS page
↑ ^104.0 ^104.1 ^104.2 ^104.3 ^104.4 Hulit, J et al. (2004) Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol. Cell. Biol. 24 7598-611 PubMed GONUTS page

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[PMID:9453487-31] Smits, R et al. (1998) Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114 275-83 PubMed GONUTS page

[PMID:16525027-32] 32.0 ^32.1 ^32.2 ^32.3 Kita, K et al. (2006) Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol. Biol. Cell 17 2331-45 PubMed GONUTS page

[PMID:1541640-33] 33.0 ^33.1 Moser, AR et al. (1992) The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system. J. Cell Biol. 116 1517-26 PubMed GONUTS page

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[PMID:17192415-37] Kroboth, K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol. Biol. Cell 18 910-8 PubMed GONUTS page

[PMID:9371501-38] Mahmoud, NN et al. (1997) Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res. 57 5045-50 PubMed GONUTS page

[PMID:18644872-39] 39.0 ^39.1 Phesse, TJ et al. (2008) Deficiency of Mbd2 attenuates Wnt signaling. Mol. Cell. Biol. 28 6094-103 PubMed GONUTS page

[PMID:15550389-40] 40.0 ^40.1 ^40.2 Qian, CN et al. (2005) Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J. Biol. Chem. 280 3938-45 PubMed GONUTS page

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[PMID:10346819-43] 43.0 ^43.1 ^43.2 Smits, R et al. (1999) Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 13 1309-21 PubMed GONUTS page

[PMID:9515784-44] Baker, SM et al. (1998) Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res. 58 1087-9 PubMed GONUTS page

[PMID:9506519-45] Takaku, K et al. (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92 645-56 PubMed GONUTS page

[PMID:9288104-46] Cormier, RT et al. (1997) Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat. Genet. 17 88-91 PubMed GONUTS page

[PMID:9159163-47] Gould, KA & Dove, WF (1997) Localized gene action controlling intestinal neoplasia in mice. Proc. Natl. Acad. Sci. U.S.A. 94 5848-53 PubMed GONUTS page

[PMID:8978063-48] Gould, KA et al. (1996) Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics 144 1777-85 PubMed GONUTS page

[PMID:8978062-49] Gould, KA et al. (1996) Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144 1769-76 PubMed GONUTS page

[PMID:8945508-50] 50.0 ^50.1 Oshima, M et al. (1996) Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87 803-9 PubMed GONUTS page

[PMID:18719115-51] Yoshimizu, T et al. (2008) The H19 locus acts in vivo as a tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 105 12417-22 PubMed GONUTS page

[PMID:18656477-52] 52.0 ^52.1 Dahlhoff, M et al. (2008) Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett. 582 2911-5 PubMed GONUTS page

[PMID:18485889-53] Elander, N et al. (2008) Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem. Biophys. Res. Commun. 372 249-53 PubMed GONUTS page

[PMID:18464259-54] Giroux, V et al. (2008) Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int. J. Cancer 123 303-11 PubMed GONUTS page

[PMID:18258607-55] Mutoh, M et al. (2008) Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Carcinogenesis 29 824-9 PubMed GONUTS page

[PMID:17989230-56] Shibata, H et al. (2007) Alpha-catenin is essential in intestinal adenoma formation. Proc. Natl. Acad. Sci. U.S.A. 104 18199-204 PubMed GONUTS page

[PMID:17956267-57] Leitges, M (2007) Functional PKC in vivo analysis using deficient mouse models. Biochem. Soc. Trans. 35 1018-20 PubMed GONUTS page

[PMID:17893885-58] Ploplis, VA et al. (2007) A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. J. Pathol. 213 266-74 PubMed GONUTS page

[PMID:17875695-59] Blanc, V et al. (2007) Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. Cancer Res. 67 8565-73 PubMed GONUTS page

[PMID:17681179-60] Li, P et al. (2007) Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology 133 599-607 PubMed GONUTS page

[PMID:17671182-61] Ghaleb, AM et al. (2007) Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 67 7147-54 PubMed GONUTS page

[PMID:17615359-62] Rakoff-Nahoum, S & Medzhitov, R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317 124-7 PubMed GONUTS page

[PMID:17596282-63] 63.0 ^63.1 Strom, A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134 2719-25 PubMed GONUTS page

[PMID:17371273-64] Berger, FG et al. (2007) Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem. Soc. Trans. 35 336-9 PubMed GONUTS page

[PMID:17299058-65] Sansom, OJ et al. (2007) Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut 56 1410-4 PubMed GONUTS page

[PMID:16007074-66] Nateri, AS et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437 281-5 PubMed GONUTS page

[PMID:15958588-67] Tucker, JM et al. (2005) Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res. 65 5390-8 PubMed GONUTS page

[PMID:15684064-68] Schoonjans, K et al. (2005) Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc. Natl. Acad. Sci. U.S.A. 102 2058-62 PubMed GONUTS page

[PMID:15380519-69] Wang, D et al. (2004) Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6 285-95 PubMed GONUTS page

[PMID:11809702-70] Seno, H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 62 506-11 PubMed GONUTS page

[PMID:11773073-71] Dinchuk, JE et al. (2002) Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J. Biol. Chem. 277 12970-7 PubMed GONUTS page

[PMID:11731407-72] Ahn, B & Ohshima, H (2001) Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res. 61 8357-60 PubMed GONUTS page

[PMID:11606502-73] Scott, DJ et al. (2001) Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology 121 889-99 PubMed GONUTS page

[PMID:11533709-74] Sonoshita, M et al. (2001) Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat. Med. 7 1048-51 PubMed GONUTS page

[PMID:11385109-75] Stanton, JL & Green, DP (2001) Meta-analysis of gene expression in mouse preimplantation embryo development. Mol. Hum. Reprod. 7 545-52 PubMed GONUTS page

[PMID:11381263-76] Rudolph, KL et al. (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28 155-9 PubMed GONUTS page

[PMID:11274413-77] Hong, KH et al. (2001) Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 98 3935-9 PubMed GONUTS page

[PMID:11245490-78] Oshima, M et al. (2001) Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 61 1733-40 PubMed GONUTS page

[PMID:11197776-79] Taketo, MM & Takaku, K (2000) Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum. Cell 13 85-95 PubMed GONUTS page

[PMID:10987272-80] Chulada, PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60 4705-8 PubMed GONUTS page

[PMID:10969066-81] Takaku, K et al. (2000) Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J. Biol. Chem. 275 34013-6 PubMed GONUTS page

[PMID:10919675-82] Cormier, RT & Dove, WF (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res. 60 3965-70 PubMed GONUTS page

[PMID:10783317-83] Sasai, H et al. (2000) Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis 21 953-8 PubMed GONUTS page

[PMID:10716720-84] Halberg, RB et al. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc. Natl. Acad. Sci. U.S.A. 97 3461-6 PubMed GONUTS page

[PMID:10708962-85] Taketo, MM & Takaku, K () Gastro-intestinal tumorigenesis in Smad4 mutant mice. Cytokine Growth Factor Rev. 11 147-57 PubMed GONUTS page

[PMID:10626800-86] Takaku, K et al. (1999) Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Cancer Res. 59 6113-7 PubMed GONUTS page

[PMID:9927046-87] Mahmoud, NN et al. (1999) Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac. Cancer Res. 59 353-9 PubMed GONUTS page

[PMID:9865728-88] Yang, K et al. (1998) Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res. 58 5713-7 PubMed GONUTS page

[PMID:9135000-89] Oshima, H et al. (1997) Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice. Cancer Res. 57 1644-9 PubMed GONUTS page

[PMID:7954428-90] Levy, DB et al. (1994) Inactivation of both APC alleles in human and mouse tumors. Cancer Res. 54 5953-8 PubMed GONUTS page

[PMID:16638711-91] Ellender, M et al. (2006) In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia. Int. J. Radiat. Biol. 82 141-51 PubMed GONUTS page

[PMID:12370429-92] Girnun, GD et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc. Natl. Acad. Sci. U.S.A. 99 13771-6 PubMed GONUTS page

[PMID:11559569-93] Sohn, KJ et al. (2001) Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse. Cancer Res. 61 6912-7 PubMed GONUTS page

[PMID:11478486-94] Yu, CF et al. (2001) Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig. Dis. Sci. 46 1367-80 PubMed GONUTS page

[PMID:11309311-95] Moser, AR et al. (2001) Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice. Cancer Res. 61 3480-5 PubMed GONUTS page

[PMID:10535960-96] Novelli, MR et al. (1999) Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras. Proc. Natl. Acad. Sci. U.S.A. 96 12553-8 PubMed GONUTS page

[PMID:10506110-97] Pierre, F et al. (1999) T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement. Carcinogenesis 20 1953-6 PubMed GONUTS page

[PMID:10334197-98] Williamson, SL et al. (1999) Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. Carcinogenesis 20 805-10 PubMed GONUTS page

[PMID:12874278-99] Kanamori, M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J. Biol. Chem. 278 38758-64 PubMed GONUTS page

[PMID:15767571-100] 100.0 ^100.1 Rao, CV et al. (2005) Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc. Natl. Acad. Sci. U.S.A. 102 4365-70 PubMed GONUTS page

[PMID:8670282-101] Senda, T et al. (1996) The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Biochem. Biophys. Res. Commun. 223 329-34 PubMed GONUTS page

[PMID:17893240-102] Caldwell, CM et al. (2007) APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J. Cell Biol. 178 1109-20 PubMed GONUTS page

[PMID:17570218-103] Abal, M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132 2448-58 PubMed GONUTS page

[PMID:15314168-104] 104.0 ^104.1 ^104.2 ^104.3 ^104.4 Hulit, J et al. (2004) Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol. Cell. Biol. 24 7598-611 PubMed GONUTS page

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