GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:9515784
| Citation |
Baker, SM, Harris, AC, Tsao, JL, Flath, TJ, Bronner, CE, Gordon, M, Shibata, D and Liskay, RM (1998) Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res. 58:1087-9 |
|---|---|
| Abstract |
Analysis of two human familial cancer syndromes, hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis, indicates that mutations in either one of four DNA mismatch repair gene homologues or the adenomatous polyposis coli (APC) gene, respectively, are important for the development of colorectal cancer. To further investigate the role of DNA mismatch repair in intestinal tumorigenesis, we generated mice with mutations in both Apc and the DNA mismatch repair gene, Pms2. Whereas Pms2-deficient mice do not develop intestinal tumors, mice deficient in Pms2 and heterozygous for Min, an allele of Apc, develop approximately three times the number of small intestinal adenomas and four times the number of colon adenomas relative to Min and Pms2+/-;Min mice. Although Pms2 deficiency clearly increases adenoma formation in the Min background, histological analysis indicated no clear evidence for progression to carcinoma. |
| Links | |
| Keywords |
Adenoma/genetics; Adenomatous Polyposis Coli Protein; Adenosine Triphosphatases; Animals; Cytoskeletal Proteins/genetics; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Intestinal Polyps/genetics; Mice; Mice, Knockout; Mice, Mutant Strains; Microsatellite Repeats/genetics; Neoplasms, Experimental; Polymorphism, Single-Stranded Conformational; Proteins/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
