GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16950562
| Citation |
Hu, Y, Le Leu, RK and Young, GP (2007) Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac. Cancer Lett. 248:234-44 |
|---|---|
| Abstract |
The effect of APC loss on azoxymethane (AOM)-induced apoptosis and cell proliferation, as well as their regulation by sulindac was examined in colon and small intestine in APC(Min/+) mice. APC(Min/+) mice showed increased epithelial proliferation in all regions, with significant impairment of apoptosis in small intestine, but not in colon. Sulindac administration restored defective apoptosis to normal. As the apoptotic defect occurred at the major site of intestinal tumor formation in APC(Min/+) mice and as it was restored to normal by a proven chemopreventive agent, this defect in apoptosis might be a key biological consequence of APC dysfunction contributing to tumor formation. |
| Links |
PubMed Online version:10.1016/j.canlet.2006.07.009 |
| Keywords |
Animals; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Apoptosis/physiology; Azoxymethane/toxicity; Carcinogens/toxicity; Cell Proliferation/drug effects; Colon/drug effects; Colon/metabolism; Colon/pathology; Female; Genes, APC; Intestine, Small/drug effects; Intestine, Small/metabolism; Intestine, Small/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Polymerase Chain Reaction; Sulindac/pharmacology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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