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PMID:8670282
| Citation |
Senda, T, Miyashiro, I, Matsumine, A, Baeg, GH, Monden, T, Kobayashil, S, Monden, M, Toyoshima, K and Akiyama, T (1996) The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Biochem. Biophys. Res. Commun. 223:329-34 |
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| Abstract |
The APC gene is mutated in familial adenomatous polyposis and sporadic colorectal tumors. The product of this gene is a 300 kDa cytoplasmic protein associated with catenin. In the present study, we examined the subcellular localization of the APC protein and beta-catenin in the mouse colon by double-labeling immunocytochemistry. While the APC protein was localized in the lateral and apical cytoplasm and in microvilli of the epithelial cells, beta-catenin was present exclusively in the lateral cytoplasm. Double-labeling-immunoelectron microscopy demonstrated precise colocalization of the APC protein and beta-catenin along the lateral plasma membrane. These results suggest that the APC protein functions in cooperation with beta-catenin in the lateral cytoplasm but has other functions independent of beta-catenin in the apical cytoplasm and in microvilli. |
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| Keywords |
Adenomatous Polyposis Coli Protein; Animals; Cadherins/analysis; Colon/cytology; Cytoplasm/ultrastructure; Cytoskeletal Proteins/analysis; Epithelial Cells; Epithelium/ultrastructure; Genes, APC; Immunohistochemistry; Intestinal Mucosa/cytology; Intestinal Mucosa/ultrastructure; Male; Mice; Mice, Inbred Strains; Microscopy, Immunoelectron; Microvilli/ultrastructure; Trans-Activators; beta Catenin |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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