PMID:11731407

Citation	Ahn, B and Ohshima, H (2001) Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res. 61:8357-60
Abstract	Inducible nitric oxide synthase (iNOS) was shown to be expressed in normal mucosa and adenoma of small and large intestines of Apc(Min/+) mice by reverse transcription-PCR and immunohistochemistry. Administration of the iNOS inhibitor aminoguanidine (1.5 g/liter) in drinking water or an L-arginine-deficient diet to Apc(Min/+) mice resulted in a significant decrease in adenoma development in the small but not the large intestine. Similarly, iNOS-gene knockout Apc(Min/+) mice (Apc(Min/+) iNOS(-/-) or Apc(Min/+) iNOS(-/+)) developed significantly fewer adenomas in both small and large intestines than Apc(Min/+) iNOS(+/+) mice. These results suggest that iNOS-selective inhibitors could be used as a potential chemopreventive agent for colorectal cancers.
Links	PubMed
Keywords	Adenoma/enzymology; Adenoma/genetics; Adenoma/therapy; Animals; Arginine/administration & dosage; Arginine/deficiency; Enzyme Inhibitors/pharmacology; Female; Genes, APC; Guanidines/pharmacology; Intestinal Mucosa/enzymology; Intestinal Neoplasms/enzymology; Intestinal Neoplasms/genetics; Intestinal Neoplasms/therapy; Intestinal Polyps/genetics; Intestinal Polyps/metabolism; Intestinal Polyps/therapy; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide/antagonists & inhibitors; Nitric Oxide/biosynthesis; Nitric Oxide Synthase/antagonists & inhibitors; Nitric Oxide Synthase/biosynthesis; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase Type II; RNA, Messenger/biosynthesis
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