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PMID:11606502
| Citation |
Scott, DJ, Hull, MA, Cartwright, EJ, Lam, WK, Tisbury, A, Poulsom, R, Markham, AF, Bonifer, C and Coletta, PL (2001) Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology 121:889-99 |
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| Abstract |
The role of the inducible isoform of nitric oxide synthase (Nos2 or iNOS) in intestinal tumorigenesis is unclear. Conflicting data also exist regarding the ability of Nos2 to modulate expression and/or activity of cyclooxygenase 2 (Cox-2), which promotes intestinal tumorigenesis. Therefore, we determined the effect of a null Nos2 genotype on intestinal tumorigenesis and Cox-2 expression/activity in the Apc(Min/+) mouse model of familial adenomatous polyposis. |
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| Keywords |
Adenomatous Polyposis Coli Protein/deficiency; Adenomatous Polyposis Coli Protein/genetics; Adenomatous Polyposis Coli Protein/metabolism; Animals; Colon/enzymology; Cyclooxygenase 2; DNA Primers; Genetic Predisposition to Disease; In Situ Hybridization; Intestinal Neoplasms/enzymology; Intestinal Neoplasms/genetics; Intestine, Small/enzymology; Isoenzymes/genetics; Macrophages/enzymology; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase/deficiency; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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