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PMID:8978063
| Citation |
Gould, KA, Luongo, C, Moser, AR, McNeley, MK, Borenstein, N, Shedlovsky, A, Dove, WF, Hong, K, Dietrich, WF and Lander, ES (1996) Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics 144:1777-85 |
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| Abstract |
As genetic mapping of quantitative trait loci (QTL) becomes routine, the challenge is to identify the underlying genes. This paper develops rigorous genetic tests for evaluation of candidate genes for a QTL, involving determination of allelic status in inbred strains and fine-structure genetic mapping. For the Mom1 modifier of intestinal adenomas caused by ApcMin, these tests are used to evaluate two candidate genes: Pla2g2a, a secretory phospholipase, and Rap1GAP, a GTPase activating protein. Rap1GAP passes the first test but is excluded by a single fine-structure recombinant. Pla2g2a passes both tests and is a strong candidate for Mom1. Significantly, we also find that ApcMin-induced adenomas remain heterozygous for the Mom1 region, consistent with Mom1 acting outside the tumor lineage and encoding a secreted product. |
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| Keywords |
Adenoma/genetics; Alleles; Animals; Chromosome Mapping; Genes, APC; Intestinal Neoplasms/genetics; Mice |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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