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PMID:10451698
| Citation |
van der Houven van Oordt, CW, Smits, R, Schouten, TG, Houwing-Duistermaat, JJ, Williamson, SL, Luz, A, Meera Khan, P, van der Eb, AJ, Breuer, ML and Fodde, R (1999) The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. Genes Chromosomes Cancer 24:191-8 |
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| Abstract |
The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the ApcMin model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele. |
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| Keywords |
Adenomatous Polyposis Coli/genetics; Animals; Epidermal Cyst/genetics; Female; Fibromatosis, Aggressive/genetics; Gastrointestinal Neoplasms/genetics; Genetic Predisposition to Disease/genetics; Loss of Heterozygosity/genetics; Male; Mammary Neoplasms, Animal/genetics; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Neoplasms, Multiple Primary/genetics; Neoplasms, Radiation-Induced/genetics; Ovarian Neoplasms/genetics; Skin Neoplasms/genetics; X-Rays |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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