PMID:17681179

Citation	Li, P, Schulz, S, Bombonati, A, Palazzo, JP, Hyslop, TM, Xu, Y, Baran, AA, Siracusa, LD, Pitari, GM and Waldman, SA (2007) Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology 133:599-607
Abstract	The most commonly lost gene products in colorectal carcinogenesis include guanylin and uroguanylin, endogenous ligands for guanylyl cyclase C (GCC). Beyond intestinal fluid balance, GCC mediates diarrhea induced by bacterial enterotoxins, and an inverse relationship exists between enterotoxigenic Escherichia coli infections producing the exogenous GCC ligand ST and colorectal cancer worldwide. However, the role of GCC in neoplasia remains obscure.
Links	PubMed Online version:10.1053/j.gastro.2007.05.052
Keywords	Animals; Apoptosis; Azoxymethane; Cell Cycle Proteins/analysis; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; Cell Transformation, Neoplastic/pathology; Colonic Neoplasms/chemically induced; Colonic Neoplasms/enzymology; Colonic Neoplasms/genetics; Colonic Neoplasms/pathology; DNA Damage; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Genes, APC; Guanylate Cyclase/deficiency; Guanylate Cyclase/genetics; Guanylate Cyclase/metabolism; Intestinal Neoplasms/chemically induced; Intestinal Neoplasms/enzymology; Intestinal Neoplasms/genetics; Intestinal Neoplasms/pathology; Intestine, Small/enzymology; Intestine, Small/pathology; Ki-67 Antigen/analysis; Loss of Heterozygosity; Mice; Mice, Knockout; Mutation; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide/deficiency; Receptors, Peptide/genetics; Receptors, Peptide/metabolism; beta Catenin/genetics; beta Catenin/metabolism
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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