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PMID:17299058
| Citation |
Sansom, OJ, Mansergh, FC, Evans, MJ, Wilkins, JA and Clarke, AR (2007) Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut 56:1410-4 |
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| Abstract |
SPARC (secreted protein acidic, rich in cysteine) is a matricellular protein that has been found to be activated in a number of human cancers. More recently, it has been shown to be upregulated in human gastric and colorectal cancer. We therefore wished to address the functional importance of SPARC upregulation to intestinal tumorigenesis in vivo. |
| Links |
PubMed PMC2000234 Online version:10.1136/gut.2006.116921 |
| Keywords |
Adenocarcinoma/metabolism; Adenoma/metabolism; Animals; Cell Movement; Cell Transformation, Neoplastic; Colon/metabolism; Colorectal Neoplasms/metabolism; Disease Models, Animal; Enterocytes/physiology; Intestinal Neoplasms/metabolism; Mice; Mice, Inbred C57BL; Neoplasm Proteins/deficiency; Neoplasm Proteins/metabolism; Osteonectin/deficiency; Osteonectin/genetics; Osteonectin/metabolism; Polymerase Chain Reaction/methods; RNA, Messenger/genetics; RNA, Neoplasm/genetics; Up-Regulation |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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