PMID:18656477

Citation	Dahlhoff, M, Horst, D, Gerhard, M, Kolligs, FT, Wolf, E and Schneider, MR (2008) Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett. 582:2911-5
Abstract	We employed transgenic mice overexpressing betacellulin (BTC) to study its effects in the gut. BTC stimulated crypt cell proliferation and markedly increased intestinal size, while the crypt-villus architecture was preserved. Introduction of a dominant negative epidermal growth factor receptor (EGFR) completely abolished the intestinal hyperplasia. BTC increased polyp multiplicity but did not change the mean size or the histological quality of intestinal polyps in Apc(+/Min) mice. Analysis of intact and cleaved caspase-3 levels indicated that BTC has anti-apoptotic effects in the intestinal epithelium. We conclude that increased BTC levels support the survival of nascent adenomas in Apc(+/Min) mice, resulting in a larger total polyp number at later stages.
Links	PubMed Online version:10.1016/j.febslet.2008.07.026
Keywords	Adenomatous Polyposis Coli/genetics; Adenomatous Polyposis Coli/pathology; Adenomatous Polyposis Coli Protein/genetics; Animals; Cell Proliferation; Hyperplasia/genetics; Hyperplasia/pathology; Intercellular Signaling Peptides and Proteins/genetics; Intercellular Signaling Peptides and Proteins/physiology; Intestinal Mucosa/abnormalities; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Intestinal Neoplasms/genetics; Intestinal Neoplasms/pathology; Mice; Mice, Transgenic; Organ Size/genetics; Receptor, Epidermal Growth Factor/genetics
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