GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10919675
| Citation |
Cormier, RT and Dove, WF (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res. 60:3965-70 |
|---|---|
| Abstract |
Altered patterns of the 5-cytosine methylation of genomic DNA are associated with the development of a wide range of human cancers. We have studied the mechanisms and genetic pathways by which a targeted heterozygous deficiency in the murine 5-cytosine DNA methyltransferase gene (Dnmt1(N/+)) diminishes intestinal tumorigenesis in C57BL/6-multiple intestinal neoplasia (Min)/+ mice. We found that Dnmt1(N/+) retards the net growth rate of intestinal adenomas and reduces tumor multiplicity by approximately 50%. This tumor resistance affects the entire intestinal tract and is independent of the status of modifier of Min 1 and p53, two loci that have been found to confer strong resistance to Min-induced neoplasia Interestingly, Dnmt/(N/+) and modifier of Min 1 resistance interact synergistically, together virtually eliminating tumor incidence. This finding may provide an insight into potential combinatorial therapeutic approaches for treating human colon cancer. |
| Links | |
| Keywords |
Adenoma/drug therapy; Adenoma/genetics; Adenoma/pathology; Age Factors; Alleles; Animals; Apoptosis/genetics; Bromodeoxyuridine/metabolism; Cell Division/drug effects; DNA (Cytosine-5-)-Methyltransferase/genetics; DNA (Cytosine-5-)-Methyltransferase/physiology; DNA Methylation; DNA Replication/genetics; Female; Genes, p53/genetics; Genotype; Germ-Line Mutation; Intestinal Neoplasms/drug therapy; Intestinal Neoplasms/genetics; Intestinal Neoplasms/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mitosis/genetics; Mutagenesis, Site-Directed; Neoplasms, Experimental/drug therapy; Neoplasms, Experimental/genetics; Neoplasms, Experimental/pathology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
