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Gupta, RA, Wang, D, Katkuri, S, Wang, H, Dey, SK and DuBois, RN (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat. Med. 10:245-7


We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth.


PubMed Online version:10.1038/nm993


Adenoma/metabolism; Adenoma/pathology; Adenomatous Polyposis Coli Protein/metabolism; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Genes, APC; Humans; Intestinal Neoplasms/metabolism; Intestinal Neoplasms/pathology; Intestinal Polyps/metabolism; Intestinal Polyps/pathology; Ligands; Mice; Receptors, Cytoplasmic and Nuclear/agonists; Receptors, Cytoplasmic and Nuclear/metabolism; Thiazoles/metabolism; Thiazoles/pharmacology; Transcription Factors/agonists; Transcription Factors/metabolism



Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

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