GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Gupta, RA, Wang, D, Katkuri, S, Wang, H, Dey, SK and DuBois, RN (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat. Med. 10:245-7
We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth.
Adenoma/metabolism; Adenoma/pathology; Adenomatous Polyposis Coli Protein/metabolism; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Genes, APC; Humans; Intestinal Neoplasms/metabolism; Intestinal Neoplasms/pathology; Intestinal Polyps/metabolism; Intestinal Polyps/pathology; Ligands; Mice; Receptors, Cytoplasmic and Nuclear/agonists; Receptors, Cytoplasmic and Nuclear/metabolism; Thiazoles/metabolism; Thiazoles/pharmacology; Transcription Factors/agonists; Transcription Factors/metabolism
|Gene product||Qualifier||GO ID||GO term name||Evidence Code||with/from||Aspect||Notes||Status|
See Help:References for how to manage references in GONUTS.