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MOUSE:FZD3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Fzd3 | |
| Protein Name(s) | Frizzled-3
Fz-3 mFz3 | |
| External Links | ||
| UniProt | Q61086 | |
| EMBL | U43205 | |
| CCDS | CCDS27212.1 | |
| RefSeq | NP_067433.1 | |
| UniGene | Mm.214687 Mm.404299 | |
| ProteinModelPortal | Q61086 | |
| SMR | Q61086 | |
| BioGrid | 199776 | |
| MINT | MINT-4997253 | |
| MEROPS | I93.001 | |
| PhosphoSite | Q61086 | |
| MaxQB | Q61086 | |
| PRIDE | Q61086 | |
| DNASU | 14365 | |
| Ensembl | ENSMUST00000131309 | |
| GeneID | 14365 | |
| KEGG | mmu:14365 | |
| UCSC | uc007ujb.2 | |
| CTD | 7976 | |
| MGI | MGI:108476 | |
| eggNOG | NOG259824 | |
| GeneTree | ENSGT00760000118864 | |
| HOGENOM | HOG000233237 | |
| HOVERGEN | HBG006977 | |
| InParanoid | Q61086 | |
| KO | K02329 | |
| OMA | MSWIVFY | |
| OrthoDB | EOG7M3J01 | |
| PhylomeDB | Q61086 | |
| TreeFam | TF317907 | |
| Reactome | REACT_203973 REACT_221970 | |
| NextBio | 285831 | |
| PRO | PR:Q61086 | |
| Proteomes | UP000000589 | |
| Bgee | Q61086 | |
| CleanEx | MM_FZD3 | |
| ExpressionAtlas | Q61086 | |
| Genevestigator | Q61086 | |
| GO | GO:0045177 GO:0016324 GO:0030424 GO:0005737 GO:0030425 GO:0016021 GO:0016328 GO:0032589 GO:0043025 GO:0005886 GO:0004930 GO:0030165 GO:0042813 GO:0017147 GO:0060070 GO:0033278 GO:0071679 GO:0001736 GO:0021754 GO:0007199 GO:0008406 GO:0001942 GO:0042472 GO:0030901 GO:1900118 GO:0045976 GO:0001843 GO:0001764 GO:0002052 GO:0036342 GO:0006357 GO:0061549 GO:0001944 | |
| Gene3D | 1.10.2000.10 | |
| InterPro | IPR000539 IPR015526 IPR020067 IPR026553 IPR017981 | |
| PANTHER | PTHR11309 PTHR11309:SF22 | |
| Pfam | PF01534 PF01392 | |
| PRINTS | PR00489 | |
| SMART | SM00063 | |
| SUPFAM | SSF63501 | |
| PROSITE | PS50038 PS50261 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0001764 |
neuron migration |
ECO:0000315 |
P |
Fig.5D |
complete | |||||
|
involved_in |
GO:0036514 |
dopaminergic neuron axon guidance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036515 |
serotonergic neuron axon guidance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0002028) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904938 |
planar cell polarity pathway involved in axon guidance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
has_input:(UniProtKB:P22725)|has_input:(UniProtKB:P28047) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900118 |
negative regulation of execution phase of apoptosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045976 |
negative regulation of mitotic cell cycle, embryonic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002052 |
positive regulation of neuroblast proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061549 |
sympathetic ganglion development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0048786 |
presynaptic active zone |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001942 |
hair follicle development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035567 |
non-canonical Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108570 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017147 |
Wnt-protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0016797 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071679 |
commissural neuron axon guidance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388632 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045177 |
apical part of cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045177 |
apical part of cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045177 |
apical part of cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042472 |
inner ear morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108474 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0036342 |
post-anal tail morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_participant:(EMAPA:16748) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0033278 |
cell proliferation in midbrain |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108474 |
P |
occurs_in:(EMAPA:16039) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0032433 |
filopodium tip |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030901 |
midbrain development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108474 |
P |
results_in_development_of:(EMAPA:16039) |
Seeded From UniProt |
complete | |
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017147 |
Wnt-protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016328 |
lateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000589) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000589) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17577) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001843 |
neural tube closure |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108474 |
P |
has_participant:(EMAPA:16530) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001764 |
neuron migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2388632 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001736 |
establishment of planar polarity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108474 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051602 |
response to electrical stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0RCN5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0RCN5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0RCN5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NPG1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NPG1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017147 |
Wnt-protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NPG1 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NPG1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9NPG1 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-NUL-3965440 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016324 |
apical plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Qu, Y et al. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J. Neurosci. 30 9392-401 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Fenstermaker, AG et al. (2010) Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J. Neurosci. 30 16053-64 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Armstrong, A et al. (2011) Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. J. Neurosci. 31 2371-81 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Davis, EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3 32 PubMed GONUTS page
- ↑ Xu, Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116 883-95 PubMed GONUTS page
- ↑ Hung, BS et al. (2001) Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes. J. Invest. Dermatol. 116 940-6 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Lyuksyutova, AI et al. (2003) Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science 302 1984-8 PubMed GONUTS page
- ↑ Matsuyama, M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 5 e1000427 PubMed GONUTS page
- ↑ Montcouquiol, M et al. (2006) Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J. Neurosci. 26 5265-75 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Wang, Y et al. (2006) The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J. Neurosci. 26 2147-56 PubMed GONUTS page
- ↑ Vogel, P et al. (2012) Congenital hydrocephalus in genetically engineered mice. Vet. Pathol. 49 166-81 PubMed GONUTS page
- ↑ 13.0 13.1 Stuebner, S et al. (2010) Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Dev. Dyn. 239 246-60 PubMed GONUTS page
- ↑ Onishi, K et al. (2013) Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J. Neurosci. 33 19071-85 PubMed GONUTS page
- ↑ Tissir, F et al. (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat. Neurosci. 13 700-7 PubMed GONUTS page
- ↑ 16.0 16.1 Grimsley-Myers, CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J. Neurosci. 29 15859-69 PubMed GONUTS page
- ↑ Merte, J et al. (2010) Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat. Cell Biol. 12 41-6; sup pp 1-8 PubMed GONUTS page
c
g
m
n
- GO:1900118 ! negative regulation of execution phase of apoptosis
- GO:0045976 ! negative regulation of mitotic cell cycle, embryonic
- GO:0007399 ! nervous system development
- GO:0001843 ! neural tube closure
- GO:0043025 ! neuronal cell body
- GO:0001764 ! neuron migration
- GO:0035567 ! non-canonical Wnt signaling pathway
p
s
