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DANRE:Q90YL7

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided. (synonyms: zfz2 (ECO:0000313 with EMBL:AAK56401.1))
Protein Name(s) Frizzled homolog 2 (ECO:0000313 with EMBL:AAH56524.1)

Frizzled-2 (ECO:0000313 with EMBL:AAK56401.1)

External Links
UniProt Q90YL7
EMBL BC056524
AY033592
RefSeq NP_571215.1
UniGene Dr.12607
SMR Q90YL7
MEROPS I93.001
GeneID 30370
KEGG dre:30370
CTD 2535
ZFIN ZDB-GENE-990415-224
HOGENOM HOG000233236
HOVERGEN HBG006977
KO K02235
PhylomeDB Q90YL7
NextBio 20806790
GO GO:0045177
GO:0005737
GO:0016021
GO:0032589
GO:0005886
GO:0030165
GO:0042813
GO:0017147
GO:0007409
GO:0007420
GO:0060070
GO:0016477
GO:0042384
GO:0060027
GO:0007368
GO:0031018
GO:0030855
GO:0007199
GO:0008406
GO:0003146
GO:0001947
GO:0061341
GO:0070654
GO:0001944
GO:0007223
Gene3D 1.10.2000.10
InterPro IPR000539
IPR015526
IPR020067
IPR026550
IPR017981
PANTHER PTHR11309
PTHR11309:SF34
Pfam PF01534
PF01392
PRINTS PR00489
SMART SM00063
SUPFAM SSF63501
PROSITE PS50038
PS50261

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001947

heart looping

PMID:17013396[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003146

heart jogging

PMID:17013396[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017981

F

Seeded From UniProt

complete

GO:0004930

G-protein coupled receptor activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000139394

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:20660632[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000539
InterPro:IPR017981

P

Seeded From UniProt

complete

GO:0007186

G-protein coupled receptor signaling pathway

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000139394

P

Seeded From UniProt

complete

GO:0007223

Wnt signaling pathway, calcium modulating pathway

PMID:16246260[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-051207-1
ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17013396[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3
ZFIN:ZDB-MRPHLNO-061207-1

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:17013396[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000539
InterPro:IPR017981

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000139394

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026550

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

GO:0016477

cell migration

PMID:16246260[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3

P

Seeded From UniProt

complete

GO:0017147

Wnt-protein binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000139394

F

Seeded From UniProt

complete

GO:0031018

endocrine pancreas development

PMID:16246260[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3

P

Seeded From UniProt

complete

GO:0042384

cilium assembly

PMID:17013396[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3

P

Seeded From UniProt

complete

GO:0042813

Wnt-activated receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026550

F

Seeded From UniProt

complete

GO:0042813

Wnt-activated receptor activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000139394

F

Seeded From UniProt

complete

GO:0060027

convergent extension involved in gastrulation

PMID:11477686[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3

P

Seeded From UniProt

complete

GO:0060027

convergent extension involved in gastrulation

PMID:12676324[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051207-2
ZFIN:ZDB-MRPHLNO-051207-3

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000139394

P

Seeded From UniProt

complete

GO:0061341

non-canonical Wnt signaling pathway involved in heart development

PMID:17013396[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0070654

sensory epithelium regeneration

PMID:21911394[6]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Oishi, I et al. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nat. Genet. 38 1316-22 PubMed GONUTS page
  2. Lin, S et al. (2010) Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J. Cell Biol. 190 263-78 PubMed GONUTS page
  3. 3.0 3.1 3.2 Kim, HJ et al. (2005) Wnt5 signaling in vertebrate pancreas development. BMC Biol. 3 23 PubMed GONUTS page
  4. Sumanas, S et al. (2001) Zebrafish frizzled-2 morphant displays defects in body axis elongation. Genesis 30 114-8 PubMed GONUTS page
  5. Kilian, B et al. (2003) The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech. Dev. 120 467-76 PubMed GONUTS page
  6. Ramachandran, R et al. (2011) Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration. Proc. Natl. Acad. Sci. U.S.A. 108 15858-63 PubMed GONUTS page