DANRE:Q90YL7

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	No Information Provided. (synonyms: zfz2 (ECO:0000313 with EMBL:AAK56401.1))
Protein Name(s)	Frizzled homolog 2 (ECO:0000313 with EMBL:AAH56524.1) Frizzled-2 (ECO:0000313 with EMBL:AAK56401.1)
External Links
UniProt	Q90YL7
EMBL	BC056524 AY033592
RefSeq	NP_571215.1
UniGene	Dr.12607
SMR	Q90YL7
MEROPS	I93.001
GeneID	30370
KEGG	dre:30370
CTD	2535
ZFIN	ZDB-GENE-990415-224
HOGENOM	HOG000233236
HOVERGEN	HBG006977
KO	K02235
PhylomeDB	Q90YL7
NextBio	20806790
GO	GO:0045177 GO:0005737 GO:0016021 GO:0032589 GO:0005886 GO:0030165 GO:0042813 GO:0017147 GO:0007409 GO:0007420 GO:0060070 GO:0016477 GO:0042384 GO:0060027 GO:0007368 GO:0031018 GO:0030855 GO:0007199 GO:0008406 GO:0003146 GO:0001947 GO:0061341 GO:0070654 GO:0001944 GO:0007223
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR026550 IPR017981
PANTHER	PTHR11309 PTHR11309:SF34
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001947	heart looping	PMID:17013396^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0003146	heart jogging	PMID:17013396^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	F	Seeded From UniProt	complete
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000139394	F	Seeded From UniProt	complete
	GO:0005886	plasma membrane	PMID:20660632^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt	complete
	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000539 InterPro:IPR017981	P	Seeded From UniProt	complete
	GO:0007186	G-protein coupled receptor signaling pathway	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000139394	P	Seeded From UniProt	complete
	GO:0007223	Wnt signaling pathway, calcium modulating pathway	PMID:16246260^[3]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-051207-1 ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3	P	Seeded From UniProt	complete
	GO:0007275	multicellular organismal development	GO_REF:0000038	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
	GO:0007368	determination of left/right symmetry	PMID:17013396^[1]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3 ZFIN:ZDB-MRPHLNO-061207-1	P	Seeded From UniProt	complete
	GO:0007368	determination of left/right symmetry	PMID:17013396^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3	P	Seeded From UniProt	complete
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000539 InterPro:IPR017981	C	Seeded From UniProt	complete
	GO:0016020	membrane	GO_REF:0000038	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
	GO:0016021	integral component of membrane	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000139394	C	Seeded From UniProt	complete
	GO:0016021	integral component of membrane	GO_REF:0000038	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
	GO:0016055	Wnt signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026550	P	Seeded From UniProt	complete
	GO:0016055	Wnt signaling pathway	GO_REF:0000038	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
	GO:0016477	cell migration	PMID:16246260^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3	P	Seeded From UniProt	complete
	GO:0017147	Wnt-protein binding	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000139394	F	Seeded From UniProt	complete
	GO:0031018	endocrine pancreas development	PMID:16246260^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3	P	Seeded From UniProt	complete
	GO:0042384	cilium assembly	PMID:17013396^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3	P	Seeded From UniProt	complete
	GO:0042813	Wnt-activated receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR026550	F	Seeded From UniProt	complete
	GO:0042813	Wnt-activated receptor activity	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000139394	F	Seeded From UniProt	complete
	GO:0060027	convergent extension involved in gastrulation	PMID:11477686^[4]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3	P	Seeded From UniProt	complete
	GO:0060027	convergent extension involved in gastrulation	PMID:12676324^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051207-2 ZFIN:ZDB-MRPHLNO-051207-3	P	Seeded From UniProt	complete
	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000033	IBA: Inferred from Biological aspect of Ancestor	PANTHER:PTN000139394	P	Seeded From UniProt	complete
	GO:0061341	non-canonical Wnt signaling pathway involved in heart development	PMID:17013396^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt	complete
	GO:0070654	sensory epithelium regeneration	PMID:21911394^[6]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Oishi, I et al. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nat. Genet. 38 1316-22 PubMed GONUTS page
↑ Lin, S et al. (2010) Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J. Cell Biol. 190 263-78 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kim, HJ et al. (2005) Wnt5 signaling in vertebrate pancreas development. BMC Biol. 3 23 PubMed GONUTS page
↑ Sumanas, S et al. (2001) Zebrafish frizzled-2 morphant displays defects in body axis elongation. Genesis 30 114-8 PubMed GONUTS page
↑ Kilian, B et al. (2003) The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech. Dev. 120 467-76 PubMed GONUTS page
↑ Ramachandran, R et al. (2011) Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration. Proc. Natl. Acad. Sci. U.S.A. 108 15858-63 PubMed GONUTS page

[PMID:17013396-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Oishi, I et al. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nat. Genet. 38 1316-22 PubMed GONUTS page

[PMID:20660632-2] Lin, S et al. (2010) Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J. Cell Biol. 190 263-78 PubMed GONUTS page

[PMID:16246260-3] 3.0 ^3.1 ^3.2 Kim, HJ et al. (2005) Wnt5 signaling in vertebrate pancreas development. BMC Biol. 3 23 PubMed GONUTS page

[PMID:11477686-4] Sumanas, S et al. (2001) Zebrafish frizzled-2 morphant displays defects in body axis elongation. Genesis 30 114-8 PubMed GONUTS page

[PMID:12676324-5] Kilian, B et al. (2003) The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech. Dev. 120 467-76 PubMed GONUTS page

[PMID:21911394-6] Ramachandran, R et al. (2011) Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration. Proc. Natl. Acad. Sci. U.S.A. 108 15858-63 PubMed GONUTS page

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DANRE:Q90YL7

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References

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