GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:FZD8
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | FZD8 | |
| Protein Name(s) | Frizzled-8
Fz-8 hFz8 | |
| External Links | ||
| UniProt | Q9H461 | |
| EMBL | AB043703 AL121749 | |
| CCDS | CCDS7192.1 | |
| RefSeq | NP_114072.1 | |
| UniGene | Hs.302634 | |
| ProteinModelPortal | Q9H461 | |
| SMR | Q9H461 | |
| BioGrid | 113921 | |
| IntAct | Q9H461 | |
| STRING | 9606.ENSP00000363826 | |
| MEROPS | I93.001 | |
| PhosphoSite | Q9H461 | |
| DMDM | 17433053 | |
| PaxDb | Q9H461 | |
| PRIDE | Q9H461 | |
| DNASU | 8325 | |
| Ensembl | ENST00000374694 | |
| GeneID | 8325 | |
| KEGG | hsa:8325 | |
| UCSC | uc001iyz.1 | |
| CTD | 8325 | |
| GeneCards | GC10M035927 | |
| HGNC | HGNC:4046 | |
| HPA | HPA045025 | |
| MIM | 606146 | |
| neXtProt | NX_Q9H461 | |
| PharmGKB | PA28463 | |
| eggNOG | NOG257258 | |
| GeneTree | ENSGT00760000118864 | |
| HOGENOM | HOG000233236 | |
| HOVERGEN | HBG006977 | |
| InParanoid | Q9H461 | |
| KO | K02375 | |
| OMA | HEKVACN | |
| OrthoDB | EOG7M3J01 | |
| PhylomeDB | Q9H461 | |
| TreeFam | TF317907 | |
| Reactome | REACT_172638 REACT_18372 REACT_200716 REACT_228188 | |
| SignaLink | Q9H461 | |
| GeneWiki | FZD8 | |
| GenomeRNAi | 8325 | |
| NextBio | 31175 | |
| PRO | PR:Q9H461 | |
| Proteomes | UP000005640 | |
| Bgee | Q9H461 | |
| CleanEx | HS_FZD8 | |
| Genevestigator | Q9H461 | |
| GO | GO:0042995 GO:0005737 GO:0005794 GO:0016021 GO:0005886 GO:0004930 GO:0030165 GO:0031625 GO:0042813 GO:0017147 GO:0007409 GO:0007420 GO:0060070 GO:0008406 GO:0000122 GO:0030182 GO:0043507 GO:0045944 GO:0033077 GO:0001944 | |
| Gene3D | 1.10.2000.10 | |
| InterPro | IPR000539 IPR015526 IPR020067 IPR017981 | |
| PANTHER | PTHR11309 | |
| Pfam | PF01534 PF01392 | |
| PRINTS | PR00489 | |
| SMART | SM00063 | |
| SUPFAM | SSF63501 | |
| PROSITE | PS50038 PS50261 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
ECO:0000315 |
P |
Figure 2 |
complete | |||||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035567 |
non-canonical Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108570 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017147 |
Wnt-protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001085 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0016797 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1990851 |
Wnt-Frizzled-LRP5/6 complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043507 |
positive regulation of JUN kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033077 |
T cell differentiation in thymus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017147 |
Wnt-protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61091 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042813 |
Wnt-activated receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Voloshanenko, O et al. (2017) Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 31 4832-4844 PubMed GONUTS page
- ↑ 2.0 2.1 Wang, HQ et al. (2012) Frizzled-8 as a putative therapeutic target in human lung cancer. Biochem. Biophys. Res. Commun. 417 62-6 PubMed GONUTS page
- ↑ Luyten, A et al. (2008) The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. Mol. Biol. Cell 19 1594-604 PubMed GONUTS page
- ↑ Hao, HX et al. (2012) ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature 485 195-200 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 Saitoh, T et al. (2001) Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. Int. J. Oncol. 18 991-6 PubMed GONUTS page
c
g
n
p
t
