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MOUSE:WNT3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Wnt3 (synonyms: Int-4, Wnt-3)
Protein Name(s) Proto-oncogene Wnt-3

Proto-oncogene Int-4

External Links
UniProt P17553
EMBL M32502
CCDS CCDS25523.1
PIR A35503
RefSeq NP_033547.1
UniGene Mm.159091
ProteinModelPortal P17553
SMR P17553
BioGrid 204574
DIP DIP-39897N
IntAct P17553
STRING 10090.ENSMUSP00000000127
PhosphoSite P17553
PRIDE P17553
Ensembl ENSMUST00000000127
GeneID 22415
KEGG mmu:22415
UCSC uc007lvs.2
CTD 7473
MGI MGI:98955
eggNOG NOG284879
GeneTree ENSGT00760000118943
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid P17553
KO K00312
OMA MCGCDSH
OrthoDB EOG7C8GJ8
PhylomeDB P17553
TreeFam TF105310
Reactome REACT_207044
REACT_213918
REACT_250061
NextBio 302829
PRO PR:P17553
Proteomes UP000000589
Bgee P17553
CleanEx MM_WNT3
ExpressionAtlas P17553
Genevestigator P17553
GO GO:0005788
GO:0031012
GO:0005615
GO:0005578
GO:0005109
GO:0019904
GO:0005102
GO:0048646
GO:0009948
GO:0009952
GO:0007411
GO:0060070
GO:0044338
GO:0044339
GO:0007267
GO:0009950
GO:0035115
GO:0035116
GO:0007276
GO:0060323
GO:0060174
GO:0060173
GO:0061180
GO:0001707
GO:0048843
GO:0009887
GO:0048697
GO:0010628
GO:0007165
GO:0060064
InterPro IPR005817
IPR009141
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01843
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030177

positive regulation of Wnt receptor signaling pathway

PMID:23324743[1]

ECO:0000314

P

Figure S3 shows Wnt-3 activates Wnt/beta-catenin signal pathway by phosphorylating Lrp6 and dephosphorylating and activating beta-Catenin.

complete
CACAO 6374

involved_in

GO:0030177

positive regulation of Wnt signaling pathway

PMID:23324743[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:19000841[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q01887

F

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905474

canonical Wnt signaling pathway involved in stem cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904954

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072089

stem cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060323

head morphogenesis

PMID:18403408[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1329040

P

has_participant:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060174

limb bud formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060173

limb development

PMID:12569130[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2450902
MGI:MGI:2450903

P

results_in_development_of:(EMAPA:16778)|results_in_development_of:(EMAPA:16892)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

PMID:18403408[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1329040

P

occurs_in:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060064

Spemann organizer formation at the anterior end of the primitive streak

PMID:10431240[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178826

P

results_in_formation_of:(EMAPA:16075)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050767

regulation of neurogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048843

negative regulation of axon extension involved in axon guidance

PMID:18716223[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048697

positive regulation of collateral sprouting in absence of injury

PMID:18716223[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048646

anatomical structure formation involved in morphogenesis

PMID:10431240[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178826

P

results_in_formation_of:(EMAPA:16072)

Seeded From UniProt

complete

enables

GO:0048018

receptor ligand activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0044339

canonical Wnt signaling pathway involved in osteoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0044338

canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035116

embryonic hindlimb morphogenesis

PMID:12569130[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2450902
MGI:MGI:2450903

P

results_in_development_of:(EMAPA:17458)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035115

embryonic forelimb morphogenesis

PMID:12569130[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2450902
MGI:MGI:2450903

P

has_participant:(EMAPA:17412)

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:8167409[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

PMID:19690384[9]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009952

anterior/posterior pattern specification

PMID:10431240[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178826

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009950

dorsal/ventral axis specification

PMID:12569130[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2450902
MGI:MGI:2450903

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009948

anterior/posterior axis specification

PMID:18028899[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2450902

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007411

axon guidance

PMID:18716223[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007276

gamete generation

PMID:23469192[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1914431

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3972

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001707

mesoderm formation

PMID:10431240[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178826

P

results_in_formation_of:(EMAPA:16071)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000902

cell morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P56703

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048018

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZCR1
ensembl:ENSRNOP00000005176

C

Seeded From UniProt

complete

involved_in

GO:1905474

canonical Wnt signaling pathway involved in stem cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:1904954

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:0072089

stem cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:0061180

mammary gland epithelium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:0060174

limb bud formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:0050767

regulation of neurogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

enables

GO:0048018

receptor ligand activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

F

Seeded From UniProt

complete

involved_in

GO:0044339

canonical Wnt signaling pathway involved in osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:0044338

canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

F

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56703
ensembl:ENSP00000225512

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817
InterPro:IPR009141

P

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-MMU-3238692

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009887

animal organ morphogenesis

PMID:9889131[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007267

cell-cell signaling

PMID:9889131[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007165

signal transduction

PMID:9889131[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:9889131[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Andersson, ER et al. (2013) Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc. Natl. Acad. Sci. U.S.A. 110 E602-10 PubMed GONUTS page
  2. Lyu, J et al. (2008) Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev. Cell 15 773-80 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 Lewis, SL et al. (2008) Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development 135 1791-801 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Barrow, JR et al. (2003) Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 17 394-409 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Liu, P et al. (1999) Requirement for Wnt3 in vertebrate axis formation. Nat. Genet. 22 361-5 PubMed GONUTS page
  7. 7.0 7.1 7.2 Purro, SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J. Neurosci. 28 8644-54 PubMed GONUTS page
  8. Smolich, BD et al. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol. Biol. Cell 4 1267-75 PubMed GONUTS page
  9. Cohen, ED et al. (2009) Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J. Clin. Invest. 119 2538-49 PubMed GONUTS page
  10. Barrow, JR et al. (2007) Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev. Biol. 312 312-20 PubMed GONUTS page
  11. Tanaka, SS et al. (2013) Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS ONE 8 e57428 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page