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HUMAN:SFRP3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FRZB (synonyms: FIZ, FRE, FRP, FRZB1, SFRP3)
Protein Name(s) Secreted frizzled-related protein 3

sFRP-3 Frezzled Fritz Frizzled-related protein 1 FrzB-1

External Links
UniProt Q92765
EMBL U24163
U91903
U68057
BT019883
BC027855
CCDS CCDS2286.1
RefSeq NP_001454.2
UniGene Hs.128453
ProteinModelPortal Q92765
SMR Q92765
BioGrid 108765
IntAct Q92765
MINT MINT-8247461
STRING 9606.ENSP00000295113
PhosphoSite Q92765
DMDM 14194748
PaxDb Q92765
PRIDE Q92765
DNASU 2487
Ensembl ENST00000295113
GeneID 2487
KEGG hsa:2487
UCSC uc002upa.2
CTD 2487
GeneCards GC02M183662
HGNC HGNC:3959
HPA CAB009249
MIM 165720
605083
neXtProt NX_Q92765
PharmGKB PA28377
eggNOG NOG304384
GeneTree ENSGT00760000118864
HOGENOM HOG000231879
HOVERGEN HBG070536
InParanoid Q92765
OMA EEYLIMG
OrthoDB EOG79PJPC
PhylomeDB Q92765
SignaLink Q92765
ChiTaRS FRZB
GenomeRNAi 2487
NextBio 9825
PRO PR:Q92765
Proteomes UP000005640
Bgee Q92765
CleanEx HS_FRZB
ExpressionAtlas Q92765
Genevestigator Q92765
GO GO:0005737
GO:0005615
GO:0016020
GO:0030165
GO:0042813
GO:0017147
GO:0007420
GO:0090103
GO:0060029
GO:0060429
GO:0008406
GO:0060056
GO:0090090
GO:0061037
GO:0010721
GO:0030308
GO:0008285
GO:0070367
GO:0030178
GO:0014033
GO:0043065
GO:0045600
GO:0001501
GO:0061053
GO:0001944
GO:0016055
Gene3D 1.10.2000.10
InterPro IPR015526
IPR020067
IPR001134
IPR018933
IPR026556
IPR008993
PANTHER PTHR11309
PTHR11309:SF76
Pfam PF01392
PF01759
SMART SM00643
SM00063
SUPFAM SSF50242
SSF63501
PROSITE PS50038
PS50189

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

PMID:24431302[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017147

Wnt-protein binding

PMID:24431302[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

part_of:(GO:0030178)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:20551380[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:22261194[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:F1RYL4

C

part_of:(UBERON:0002084)

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:17471511[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

PMID:20208569[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

PMID:20208569[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97401

P

Seeded From UniProt

complete

enables

GO:0017147

Wnt-protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97401

F

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:20208569[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:892010
MGI:MGI:892032
PANTHER:PTN000885362
RGD:621075
UniProtKB:Q6FHJ7
UniProtKB:Q92765

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001085
FB:FBgn0016797
MGI:MGI:108460
MGI:MGI:108520
MGI:MGI:108570
MGI:MGI:108571
MGI:MGI:1196625
PANTHER:PTN000139394
RGD:61916
RGD:71012
UniProtKB:O75084
UniProtKB:Q13467
UniProtKB:Q14332
UniProtKB:Q8N474
UniProtKB:Q9H461
UniProtKB:Q9NPG1
UniProtKB:Q9ULV1
UniProtKB:Q9ULW2
UniProtKB:Q9UP38

P

Seeded From UniProt

complete

involved_in

GO:0035567

non-canonical Wnt signaling pathway

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108570
PANTHER:PTN000139394
UniProtKB:O60353
ZFIN:ZDB-GENE-990415-218

P

Seeded From UniProt

complete

enables

GO:0017147

Wnt-protein binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001085
FB:FBgn0016797
FB:FBgn0027342
FB:FBgn0027343
MGI:MGI:108078
MGI:MGI:108460
MGI:MGI:108474
MGI:MGI:108520
MGI:MGI:108570
MGI:MGI:108571
MGI:MGI:1196625
MGI:MGI:2136761
MGI:MGI:892032
PANTHER:PTN000139394
RGD:621075
RGD:631406
RGD:71017
UniProtKB:O00144
UniProtKB:O75084
UniProtKB:Q13467
UniProtKB:Q6FHJ7
UniProtKB:Q8N474
UniProtKB:Q9NPG1
UniProtKB:Q9UP38

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000139511
RGD:621075
UniProtKB:Q6FHJ7

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000139511
RGD:621075
UniProtKB:Q6FHJ7

C

Seeded From UniProt

complete

involved_in

GO:0045600

positive regulation of fat cell differentiation

PMID:12055200[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:18166153[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P27467

P

Seeded From UniProt

complete

involved_in

GO:0090103

cochlea morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0070367

negative regulation of hepatocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0061053

somite development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0061037

negative regulation of cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0060029

convergent extension involved in organogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0042472

inner ear morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

enables

GO:0017147

Wnt-protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

F

Seeded From UniProt

complete

involved_in

GO:0014033

neural crest cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

involved_in

GO:0010721

negative regulation of cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97401
ensembl:ENSMUSP00000028389

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:8824257[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

PMID:8824257[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
  2. ↑ Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  3. ↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
  4. ↑ Bhat, RA et al. (2007) Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function. J. Cell. Biochem. 102 1519-28 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Kongkham, PN et al. (2010) The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene 29 3017-24 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page
  8. ↑ Cho, SW et al. (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem. Biophys. Res. Commun. 367 399-405 PubMed GONUTS page
  9. ↑ 9.0 9.1 Hoang, B et al. (1996) Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J. Biol. Chem. 271 26131-7 PubMed GONUTS page
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