MOUSE:FZD5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fzd5
Protein Name(s)	Frizzled-5 Fz-5 mFz5
External Links
UniProt	Q9EQD0
EMBL	AF272146 AB052910 AK030111 AC101915 CH466548 CH466548 AF005203
CCDS	CCDS15008.1
RefSeq	NP_001036124.1 NP_073558.2
UniGene	Mm.150813 Mm.470210
ProteinModelPortal	Q9EQD0
SMR	Q9EQD0
BioGrid	199778
DIP	DIP-41260N
IntAct	Q9EQD0
MINT	MINT-1783095
STRING	10090.ENSMUSP00000067783
MEROPS	I93.001
PhosphoSite	Q9EQD0
PRIDE	Q9EQD0
Ensembl	ENSMUST00000063982 ENSMUST00000116133
GeneID	14367
KEGG	mmu:14367
UCSC	uc007bgy.1
CTD	7855
MGI	MGI:108571
eggNOG	NOG257258
GeneTree	ENSGT00760000118864
HOGENOM	HOG000233236
HOVERGEN	HBG006977
InParanoid	Q9EQD0
KO	K02375
OMA	AATYHKQ
OrthoDB	EOG7M3J01
TreeFam	TF317907
Reactome	REACT_203973 REACT_216784 REACT_221970 REACT_222715 REACT_250061
NextBio	285839
PRO	PR:Q9EQD0
Proteomes	UP000000589
CleanEx	MM_FZD5
Genevestigator	Q9EQD0
GO	GO:0042995 GO:0009986 GO:0005737 GO:0005794 GO:0000139 GO:0016021 GO:0048471 GO:0005886 GO:0005923 GO:0004930 GO:0030165 GO:0042813 GO:0017147 GO:0001525 GO:0008595 GO:0060561 GO:0007409 GO:0007420 GO:0060670 GO:0060070 GO:0048469 GO:0071219 GO:0060718 GO:0031076 GO:0008406 GO:0060716 GO:0008285 GO:0032729 GO:0043507 GO:0045944 GO:0031077 GO:0060828 GO:1901382 GO:2000810 GO:0006357 GO:0060061 GO:0060715 GO:0033077 GO:0001944 GO:0016055 GO:0044332
Gene3D	1.10.2000.10
InterPro	IPR000539 IPR015526 IPR020067 IPR026547 IPR017981
PANTHER	PTHR11309 PTHR11309:SF29
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031077	post-embryonic camera-type eye development	PMID:18832390^[1]	ECO:0000315			P		Figure 5	complete CACAO 6662
	GO:0048596	embryonic camera-type eye morphogenesis	PMID:18832390^[1]	ECO:0000315			P		Figure 4	complete CACAO 6724
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	PMID:21857966^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P22725	P	regulates_o_occurs_in:(CL:0002609) has_regulation_target:(UniProtKB:P06804)	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:21857966^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P22725	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	PMID:18832390^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031077	post-embryonic camera-type eye development	PMID:18832390^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11520064^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16890161^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11520064^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11520064^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005769	early endosome	PMID:16890161^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 PANTHER:PTN000139394 RGD:61916 RGD:71012 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q8N474 UniProtKB:Q9H461 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:1313278 MGI:MGI:1888513 PANTHER:PTN000139394 RGD:628817 RGD:71012 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q14332 UniProtKB:Q9H461 UniProtKB:Q9ULV1 UniProtKB:Q9ULW2 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108570 PANTHER:PTN000139394 UniProtKB:O60353 ZFIN:ZDB-GENE-990415-218	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001085 FB:FBgn0016797 FB:FBgn0027342 FB:FBgn0027343 MGI:MGI:108078 MGI:MGI:108460 MGI:MGI:108474 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1196625 MGI:MGI:2136761 MGI:MGI:892032 PANTHER:PTN000139394 RGD:621075 RGD:631406 RGD:71017 UniProtKB:O00144 UniProtKB:O75084 UniProtKB:Q13467 UniProtKB:Q6FHJ7 UniProtKB:Q8N474 UniProtKB:Q9NPG1 UniProtKB:Q9UP38	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0016797 MGI:MGI:108075 MGI:MGI:108460 MGI:MGI:108476 MGI:MGI:108520 MGI:MGI:108570 MGI:MGI:108571 MGI:MGI:1313278 PANTHER:PTN000139394 RGD:61916 RGD:628817 RGD:71012 UniProtKB:O00144 UniProtKB:O19116 UniProtKB:O60353 UniProtKB:O75084 UniProtKB:Q14332 UniProtKB:Q99835 UniProtKB:Q9NPG1 UniProtKB:Q9ULV1 WB:WBGene00003006 ZFIN:ZDB-GENE-990415-223	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000810	regulation of bicellular tight junction assembly	PMID:23610556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583769	P	regulates_o_occurs_in:(EMAPA:32802) regulates_o_occurs_in:(CL:0000351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901382	regulation of chorionic trophoblast cell proliferation	PMID:23610556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583769	P	regulates_o_occurs_in:(EMAPA:31872)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099054	presynapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631406	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631406	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071219	cellular response to molecule of bacterial origin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060718	chorionic trophoblast cell differentiation	PMID:23610556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583769	P	occurs_in:(EMAPA:31872)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060716	labyrinthine layer blood vessel development	PMID:11092808^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177951	P	results_in_development_of:(EMAPA:16370)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development	PMID:23610556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060670	branching involved in labyrinthine layer morphogenesis	PMID:23610556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583769	P	has_participant:(EMAPA:31873)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060561	apoptotic process involved in morphogenesis	PMID:18791178^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574771,MGI:MGI:3583769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:23610556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583769	P	regulates_o_occurs_in:(EMAPA:32802) regulates_o_occurs_in:(CL:0000351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:11265645^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060061	Spemann organizer formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:15778706^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:35777) results_in_maturation_of:(CL:0000510)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23610556^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583769	P	has_regulation_target:(MGI:MGI:108045)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631406	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	PMID:15195140^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:11265645^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031077	post-embryonic camera-type eye development	PMID:18791178^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574771,MGI:MGI:3583769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031076	embryonic camera-type eye development	PMID:18791178^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574771,MGI:MGI:3583769	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:18606138^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27467	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:631406	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:11092808^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108061 MGI:MGI:98954 MGI:MGI:98958	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008595	anterior/posterior axis specification, embryo	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18791178^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574771,MGI:MGI:3583769	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:23610556^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32802)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002726	positive regulation of T cell cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001944	vasculature development	PMID:18791178^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3574771,MGI:MGI:3583769	P	results_in_development_of:(EMAPA:17828)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:11092808^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177951	P	has_participant:(EMAPA:16370)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000578	embryonic axis specification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13467	P		Seeded From UniProt	complete
involved_in	GO:0071219	cellular response to molecule of bacterial origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
involved_in	GO:0060061	Spemann organizer formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	F		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	F		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	C		Seeded From UniProt	complete
involved_in	GO:0008595	anterior/posterior axis specification, embryo	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	C		Seeded From UniProt	complete
involved_in	GO:0002726	positive regulation of T cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	F		Seeded From UniProt	complete
involved_in	GO:0000578	embryonic axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13467 ensembl:ENSP00000354607	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539 InterPro:IPR017981	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000539	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	C		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037441	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037441	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
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Notes

References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 Liu, C & Nathans, J (2008) An essential role for frizzled 5 in mammalian ocular development. Development 135 3567-76 PubMed GONUTS page
↑ ^2.0 ^2.1 Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Yao, R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem. Biophys. Res. Commun. 286 771-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Yamamoto, H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 11 213-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Ishikawa, T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128 25-33 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhang, J et al. (2008) A nonautonomous role for retinal frizzled-5 in regulating hyaloid vitreous vasculature development. Invest. Ophthalmol. Vis. Sci. 49 5561-7 PubMed GONUTS page
↑ ^9.0 ^9.1 Staal, FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31 285-93 PubMed GONUTS page
↑ van Es, JH et al. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat. Cell Biol. 7 381-6 PubMed GONUTS page
↑ Yao, R et al. (2004) MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene 23 6023-30 PubMed GONUTS page
↑ Yamamoto, S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15 23-36 PubMed GONUTS page

[PMID:18832390-1] 1.0 ^1.1 ^1.2 ^1.3 Liu, C & Nathans, J (2008) An essential role for frizzled 5 in mammalian ocular development. Development 135 3567-76 PubMed GONUTS page

[PMID:21857966-2] 2.0 ^2.1 Li, B et al. (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 6 e22920 PubMed GONUTS page

[PMID:11520064-3] 3.0 ^3.1 ^3.2 Yao, R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem. Biophys. Res. Commun. 286 771-8 PubMed GONUTS page

[PMID:16890161-4] 4.0 ^4.1 Yamamoto, H et al. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 11 213-23 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23610556-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Lu, J et al. (2013) A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11 e1001536 PubMed GONUTS page

[PMID:11092808-7] 7.0 ^7.1 ^7.2 Ishikawa, T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128 25-33 PubMed GONUTS page

[PMID:18791178-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhang, J et al. (2008) A nonautonomous role for retinal frizzled-5 in regulating hyaloid vitreous vasculature development. Invest. Ophthalmol. Vis. Sci. 49 5561-7 PubMed GONUTS page

[PMID:11265645-9] 9.0 ^9.1 Staal, FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31 285-93 PubMed GONUTS page

[PMID:15778706-10] van Es, JH et al. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat. Cell Biol. 7 381-6 PubMed GONUTS page

[PMID:15195140-11] Yao, R et al. (2004) MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene 23 6023-30 PubMed GONUTS page

[PMID:18606138-12] Yamamoto, S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15 23-36 PubMed GONUTS page

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