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DANRE:WNT8A

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) wnt8a (synonyms: wnt-8, wnt8)
Protein Name(s) Protein Wnt-8a
External Links
UniProt P51028
EMBL U10869
AY032749
BC055535
PIR I50505
RefSeq NP_571021.3
UniGene Dr.309
BioGrid 78358
GeneID 30122
KEGG dre:30122
CTD 7478
ZFIN ZDB-GENE-980526-332
eggNOG NOG277037
HOVERGEN HBG001595
InParanoid P51028
KO K00714
PhylomeDB P51028
Reactome REACT_204274
REACT_212706
REACT_221170
NextBio 20806601
PRO PR:P51028
Proteomes UP000000437
Bgee P51028
GO GO:0005578
GO:0046872
GO:0044332
InterPro IPR005817
IPR013301
IPR018161
IPR007087
PANTHER PTHR12027
PTHR12027:SF92
Pfam PF00110
PRINTS PR01892
PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

go:0009953

Bad GO ID<input name="field[2]" type="hidden" value="" />

PMID:18762581[1]

IMP: Inferred from Mutant Phenotype

P

Figure 3B: Embryos injected with Wnt8MO showed dorsalized phenotypes

complete

GO:0001654

eye development

PMID:16854974[2]

IDA: Inferred from Direct Assay

P

complete

GO:0001654

eye development

PMID:16854974[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-011108-2

P

complete

GO:0001654

eye development

PMID:16854974[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-040310-5

P

complete

GO:0001664

G-protein-coupled receptor binding

GO_REF:0000033

PANTHER:PTHR12027_AN0

F

Missing: evidence

GO:0001707

mesoderm formation

PMID:15240553[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0001707

mesoderm formation

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-10

P

complete

GO:0001707

mesoderm formation

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-7

P

complete

GO:0001707

mesoderm formation

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-8

P

complete

GO:0001707

mesoderm formation

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-9

P

complete

GO:0001756

somitogenesis

PMID:15708563[5]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050509-2

P

complete

GO:0001756

somitogenesis

PMID:15772132[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0005102

receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

F

complete

GO:0005102

receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013301

F

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

C

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013301

C

complete

GO:0005576

extracellular region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0964

C

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0272

C

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0111

C

complete

GO:0005615

extracellular space

GO_REF:0000033

PANTHER:PTHR12027_AN0

C

Missing: evidence

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

C

complete

GO:0005886

plasma membrane

GO_REF:0000033

PANTHER:PTHR12027_AN0

C

Missing: evidence

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013301

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0007398

ectoderm development

PMID:11703928[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0007417

central nervous system development

PMID:11566861[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0007492

endoderm development

PMID:18585699[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-090304-8

P

complete

GO:0007498

mesoderm development

PMID:11703928[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0007498

mesoderm development

PMID:15772132[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050509-2

P

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

F

complete

GO:0009949

polarity specification of anterior/posterior axis

GO_REF:0000033

PANTHER:PTHR12027_AN388

P

Missing: evidence

GO:0009952

anterior/posterior pattern formation

PMID:11566861[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009952

anterior/posterior pattern formation

PMID:11703928[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0009952

anterior/posterior pattern formation

PMID:14757644[10]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009952

anterior/posterior pattern formation

PMID:15366022[11]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009952

anterior/posterior pattern formation

PMID:15772132[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050509-2

P

complete

GO:0009952

anterior/posterior pattern formation

PMID:16547521[12]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060724-3

P

complete

GO:0009952

anterior/posterior pattern formation

PMID:19471023[13]

IDA: Inferred from Direct Assay

P

complete

GO:0009952

anterior/posterior pattern formation

PMID:19572019[14]

IDA: Inferred from Direct Assay

P

complete

GO:0009953

dorsal/ventral pattern formation

PMID:15269175[15]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020130-1

P

complete

GO:0009953

dorsal/ventral pattern formation

PMID:15772132[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050509-2

P

complete

GO:0009953

dorsal/ventral pattern formation

PMID:18762581[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0009953

dorsal/ventral pattern formation

PMID:18762581[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-13

P

complete

GO:0009953

dorsal/ventral pattern formation

PMID:9753682[16]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-000328-4

P

complete

GO:0009953

dorsal/ventral pattern formation

PMID:9753682[16]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010085

polarity specification of proximal/distal axis

GO_REF:0000033

PANTHER:PTHR12027_AN388

P

Missing: evidence

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

P

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013301

P

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0879

P

complete

GO:0021512

spinal cord anterior/posterior patterning

PMID:11566861[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0005102

receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR013301

F

Seeded From UniProt

complete

GO:0030178

negative regulation of Wnt receptor signaling pathway

PMID:17510365[17]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-070822-1

P

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR013301

C

Seeded From UniProt

complete

GO:0030178

negative regulation of Wnt receptor signaling pathway

PMID:17510365[17]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-070822-2

P

complete

GO:0005576

extracellular region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0030902

hindbrain development

PMID:15797017[18]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0272

C

Seeded From UniProt

complete

GO:0030902

hindbrain development

PMID:15797017[18]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-13

P

complete

GO:0005578

proteinaceous extracellular matrix

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0111

C

Seeded From UniProt

complete

GO:0030902

hindbrain development

PMID:19341460[19]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR013301

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:15772132[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050509-2

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-10

P

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005817
InterPro:IPR013301

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-7

P

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-8

P

complete

GO:0044332

Wnt signaling pathway involved in dorsal/ventral axis specification

PMID:18762581[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030903

notochord development

PMID:16216234[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060130-9

P

complete

GO:0046872

metal ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007087

F

Seeded From UniProt

complete

GO:0035121

tail morphogenesis

PMID:15772132[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050509-2

P

complete

GO:0035121

tail morphogenesis

PMID:15772132[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0035284

brain segmentation

PMID:15703279[20]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020130-1

P

complete

GO:0035284

brain segmentation

PMID:15703279[20]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-12

P

complete

GO:0044332

Wnt receptor signaling pathway involved in dorsal/ventral axis specification

PMID:18762581[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045165

cell fate commitment

PMID:12879074[21]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980528-2059

P

complete

GO:0045165

cell fate commitment

PMID:14973296[22]

IDA: Inferred from Direct Assay

P

complete

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

PMID:14757644[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020130-1

P

complete

GO:0060070

canonical Wnt receptor signaling pathway

GO_REF:0000033

PANTHER:PTHR12027_AN0

P

Missing: evidence

GO:0060896

neural plate pattern specification

PMID:19580801[23]

IDA: Inferred from Direct Assay

P

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Ding, Y et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J. Cell Biol. 182 865-72 PubMed GONUTS page
  2. 2.0 2.1 2.2 Peng, G & Westerfield, M (2006) Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development 133 3191-200 PubMed GONUTS page
  3. Szeto, DP & Kimelman, D (2004) Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development 131 3751-60 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Ramel, MC et al. (2005) WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Dev. Biol. 287 237-48 PubMed GONUTS page
  5. Shimizu, T et al. (2005) Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev. Biol. 279 125-41 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Thorpe, CJ et al. (2005) Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development 132 1763-72 PubMed GONUTS page
  7. 7.0 7.1 7.2 Lekven, AC et al. (2001) Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev. Cell 1 103-14 PubMed GONUTS page
  8. 8.0 8.1 8.2 Erter, CE et al. (2001) Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development 128 3571-83 PubMed GONUTS page
  9. Goessling, W et al. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev. Biol. 320 161-74 PubMed GONUTS page
  10. 10.0 10.1 Phillips, BT et al. (2004) A direct role for Fgf but not Wnt in otic placode induction. Development 131 923-31 PubMed GONUTS page
  11. Ramel, MC et al. (2004) Conservation of structure and functional divergence of duplicated Wnt8s in pufferfish. Dev. Dyn. 231 441-8 PubMed GONUTS page
  12. Angers, S et al. (2006) The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 8 348-57 PubMed GONUTS page
  13. James, RG et al. (2009) Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal 2 ra25 PubMed GONUTS page
  14. Kategaya, LS et al. (2009) Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS ONE 4 e6129 PubMed GONUTS page
  15. Ramel, MC & Lekven, AC (2004) Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development 131 3991-4000 PubMed GONUTS page
  16. 16.0 16.1 Nasevicius, A et al. (1998) Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation. Development 125 4283-92 PubMed GONUTS page
  17. 17.0 17.1 Major, MB et al. (2007) Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 316 1043-6 PubMed GONUTS page
  18. 18.0 18.1 Weidinger, G et al. (2005) The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr. Biol. 15 489-500 PubMed GONUTS page
  19. Rhinn, M et al. (2009) Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal. Neural Dev 4 12 PubMed GONUTS page
  20. 20.0 20.1 Rhinn, M et al. (2005) Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development 132 1261-72 PubMed GONUTS page
  21. Agathon, A et al. (2003) The molecular nature of the zebrafish tail organizer. Nature 424 448-52 PubMed GONUTS page
  22. Lewis, JL et al. (2004) Reiterated Wnt signaling during zebrafish neural crest development. Development 131 1299-308 PubMed GONUTS page
  23. Jia, S et al. (2009) Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish. Dev. Biol. 333 273-84 PubMed GONUTS page