DANRE:WNT8A

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	wnt8a (synonyms: wnt-8, wnt8)
Protein Name(s)	Protein Wnt-8a
External Links
UniProt	P51028
EMBL	U10869 AY032749 BC055535
PIR	I50505
RefSeq	NP_571021.3
UniGene	Dr.309
BioGrid	78358
GeneID	30122
KEGG	dre:30122
CTD	7478
ZFIN	ZDB-GENE-980526-332
eggNOG	NOG277037
HOVERGEN	HBG001595
InParanoid	P51028
KO	K00714
PhylomeDB	P51028
Reactome	REACT_204274 REACT_212706 REACT_221170
NextBio	20806601
PRO	PR:P51028
Proteomes	UP000000437
Bgee	P51028
GO	GO:0005578 GO:0046872 GO:0044332
InterPro	IPR005817 IPR013301 IPR018161 IPR007087
PANTHER	PTHR12027 PTHR12027:SF92
Pfam	PF00110
PRINTS	PR01892 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification	PMID:18762581^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000742	regulation of anterior head development	PMID:24038582^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-140124-6	P	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:23533179^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-050522-216	P	Seeded From UniProt	complete
involved_in	GO:0060896	neural plate pattern specification	PMID:19580801^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:23987510^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:20685732^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0060061	Spemann organizer formation	PMID:23987510^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13 ZFIN:ZDB-MRPHLNO-131112-3	P	Seeded From UniProt	complete
involved_in	GO:0060061	Spemann organizer formation	PMID:23987510^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13	P	Seeded From UniProt	complete
involved_in	GO:0048263	determination of dorsal identity	PMID:21911385^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	PMID:14757644^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020130-1	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:12879074^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980528-2059	P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:14973296^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0001654	eye development	PMID:16854974^[11]	ECO:0000316		ZFIN:ZDB-GENE-040310-5	P		complete
involved_in	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification	PMID:23987510^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13 ZFIN:ZDB-MRPHLNO-131112-3	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:16216234^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1488 ZFIN:ZDB-MRPHLNO-060130-10 ZFIN:ZDB-MRPHLNO-060130-7 ZFIN:ZDB-MRPHLNO-060130-8 ZFIN:ZDB-MRPHLNO-060130-9	P	Seeded From UniProt	complete
involved_in	GO:0039015	cell proliferation involved in pronephros development	PMID:28359809^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13	P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	PMID:15772132^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050509-2	P	Seeded From UniProt	complete
involved_in	GO:0036342	post-anal tail morphogenesis	PMID:15772132^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0035284	brain segmentation	PMID:15703279^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0035284	brain segmentation	PMID:15703279^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020130-1	P	Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	PMID:16216234^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1488 ZFIN:ZDB-MRPHLNO-060130-10 ZFIN:ZDB-MRPHLNO-060130-7 ZFIN:ZDB-MRPHLNO-060130-8 ZFIN:ZDB-MRPHLNO-060130-9	P	Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	PMID:15772132^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050509-2	P	Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	PMID:16216234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060130-10 ZFIN:ZDB-MRPHLNO-060130-7 ZFIN:ZDB-MRPHLNO-060130-8 ZFIN:ZDB-MRPHLNO-060130-9	P	Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:15797017^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13 ZFIN:ZDB-MRPHLNO-050607-2	P	Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:19341460^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:15797017^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13	P	Seeded From UniProt	complete
involved_in	GO:0021999	neural plate anterior/posterior regionalization	PMID:26041917^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-030131-3200 ZFIN:ZDB-GENE-990415-198	P	Seeded From UniProt	complete
involved_in	GO:0021999	neural plate anterior/posterior regionalization	PMID:26041917^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-030131-3200	P	Seeded From UniProt	complete
involved_in	GO:0021512	spinal cord anterior/posterior patterning	PMID:11566861^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:17510365^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070822-2	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:17510365^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-070822-1	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21282610^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13 ZFIN:ZDB-MRPHLNO-110401-1	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21282610^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:9753682^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-000328-4	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:21282610^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13 ZFIN:ZDB-MRPHLNO-110401-1	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:16216234^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1488 ZFIN:ZDB-MRPHLNO-060130-10 ZFIN:ZDB-MRPHLNO-060130-7 ZFIN:ZDB-MRPHLNO-060130-8 ZFIN:ZDB-MRPHLNO-060130-9	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:15772132^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050509-2	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:15269175^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-010108-1 ZFIN:ZDB-GENE-010108-2	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:9753682^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:29208373^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-180919-13	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:29208373^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-180919-10	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:21282610^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:18762581^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12 ZFIN:ZDB-MRPHLNO-041217-13	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:15269175^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-020130-1	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:16547521^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060724-3	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:15772132^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050509-2	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:29208373^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-180919-13	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:29208373^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-180919-10	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:15366022^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:14757644^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:11703928^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:11566861^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:19572019^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:19471023^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:15772132^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050509-2	P	Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:11703928^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	PMID:18585699^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-090304-8	P	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:11566861^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	PMID:11703928^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:15772132^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-12	P	Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:15708563^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050509-2	P	Seeded From UniProt	complete
involved_in	GO:0001710	mesodermal cell fate commitment	PMID:16216234^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1488 ZFIN:ZDB-MRPHLNO-060130-10 ZFIN:ZDB-MRPHLNO-060130-7 ZFIN:ZDB-MRPHLNO-060130-8 ZFIN:ZDB-MRPHLNO-060130-9	P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:16216234^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060130-10 ZFIN:ZDB-MRPHLNO-060130-7 ZFIN:ZDB-MRPHLNO-060130-8 ZFIN:ZDB-MRPHLNO-060130-9	P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:15240553^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:16854974^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-040310-5	P	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:16854974^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-011108-2	P	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:16854974^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[33]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013301 InterPro:IPR034312	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013301	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013301 InterPro:IPR034312	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR013301 InterPro:IPR034312	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ding, Y et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J. Cell Biol. 182 865-72 PubMed GONUTS page
↑ Guan, R et al. (2013) rbm47, a novel RNA binding protein, regulates zebrafish head development. Dev. Dyn. 242 1395-404 PubMed GONUTS page
↑ Hayes, M et al. (2013) Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development. Development 140 1807-18 PubMed GONUTS page
↑ Jia, S et al. (2009) Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish. Dev. Biol. 333 273-84 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Özhan, G et al. (2013) Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev. Cell 26 331-45 PubMed GONUTS page
↑ Dutta, S & Dawid, IB (2010) Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output. Development 137 3013-8 PubMed GONUTS page
↑ Lu, FI et al. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant. Proc. Natl. Acad. Sci. U.S.A. 108 15876-80 PubMed GONUTS page
↑ ^8.0 ^8.1 Phillips, BT et al. (2004) A direct role for Fgf but not Wnt in otic placode induction. Development 131 923-31 PubMed GONUTS page
↑ Agathon, A et al. (2003) The molecular nature of the zebrafish tail organizer. Nature 424 448-52 PubMed GONUTS page
↑ Lewis, JL et al. (2004) Reiterated Wnt signaling during zebrafish neural crest development. Development 131 1299-308 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Peng, G & Westerfield, M (2006) Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development 133 3191-200 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Ramel, MC et al. (2005) WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Dev. Biol. 287 237-48 PubMed GONUTS page
↑ Naylor, RW et al. (2017) Wnt8a expands the pool of embryonic kidney progenitors in zebrafish. Dev. Biol. 425 130-141 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Thorpe, CJ et al. (2005) Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development 132 1763-72 PubMed GONUTS page
↑ ^15.0 ^15.1 Rhinn, M et al. (2005) Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development 132 1261-72 PubMed GONUTS page
↑ ^16.0 ^16.1 Weidinger, G et al. (2005) The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr. Biol. 15 489-500 PubMed GONUTS page
↑ Rhinn, M et al. (2009) Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal. Neural Dev 4 12 PubMed GONUTS page
↑ ^18.0 ^18.1 Ma, Y et al. (2015) The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. J. Neurosci. 35 8493-506 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Erter, CE et al. (2001) Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development 128 3571-83 PubMed GONUTS page
↑ ^20.0 ^20.1 Major, MB et al. (2007) Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 316 1043-6 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Li, Z et al. (2011) Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc. Natl. Acad. Sci. U.S.A. 108 3116-23 PubMed GONUTS page
↑ ^22.0 ^22.1 Nasevicius, A et al. (1998) Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation. Development 125 4283-92 PubMed GONUTS page
↑ ^23.0 ^23.1 Ramel, MC & Lekven, AC (2004) Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development 131 3991-4000 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Hino, H et al. (2018) Roles of maternal wnt8a transcripts in axis formation in zebrafish. Dev. Biol. 434 96-107 PubMed GONUTS page
↑ Angers, S et al. (2006) The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 8 348-57 PubMed GONUTS page
↑ Ramel, MC et al. (2004) Conservation of structure and functional divergence of duplicated Wnt8s in pufferfish. Dev. Dyn. 231 441-8 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Lekven, AC et al. (2001) Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev. Cell 1 103-14 PubMed GONUTS page
↑ Kategaya, LS et al. (2009) Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS ONE 4 e6129 PubMed GONUTS page
↑ James, RG et al. (2009) Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal 2 ra25 PubMed GONUTS page
↑ Goessling, W et al. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev. Biol. 320 161-74 PubMed GONUTS page
↑ Shimizu, T et al. (2005) Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev. Biol. 279 125-41 PubMed GONUTS page
↑ Szeto, DP & Kimelman, D (2004) Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development 131 3751-60 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18762581-1] 1.0 ^1.1 Ding, Y et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J. Cell Biol. 182 865-72 PubMed GONUTS page

[PMID:24038582-2] Guan, R et al. (2013) rbm47, a novel RNA binding protein, regulates zebrafish head development. Dev. Dyn. 242 1395-404 PubMed GONUTS page

[PMID:23533179-3] Hayes, M et al. (2013) Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development. Development 140 1807-18 PubMed GONUTS page

[PMID:19580801-4] Jia, S et al. (2009) Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish. Dev. Biol. 333 273-84 PubMed GONUTS page

[PMID:23987510-5] 5.0 ^5.1 ^5.2 ^5.3 Özhan, G et al. (2013) Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev. Cell 26 331-45 PubMed GONUTS page

[PMID:20685732-6] Dutta, S & Dawid, IB (2010) Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output. Development 137 3013-8 PubMed GONUTS page

[PMID:21911385-7] Lu, FI et al. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant. Proc. Natl. Acad. Sci. U.S.A. 108 15876-80 PubMed GONUTS page

[PMID:14757644-8] 8.0 ^8.1 Phillips, BT et al. (2004) A direct role for Fgf but not Wnt in otic placode induction. Development 131 923-31 PubMed GONUTS page

[PMID:12879074-9] Agathon, A et al. (2003) The molecular nature of the zebrafish tail organizer. Nature 424 448-52 PubMed GONUTS page

[PMID:14973296-10] Lewis, JL et al. (2004) Reiterated Wnt signaling during zebrafish neural crest development. Development 131 1299-308 PubMed GONUTS page

[PMID:16854974-11] 11.0 ^11.1 ^11.2 ^11.3 Peng, G & Westerfield, M (2006) Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development 133 3191-200 PubMed GONUTS page

[PMID:16216234-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Ramel, MC et al. (2005) WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Dev. Biol. 287 237-48 PubMed GONUTS page

[PMID:28359809-13] Naylor, RW et al. (2017) Wnt8a expands the pool of embryonic kidney progenitors in zebrafish. Dev. Biol. 425 130-141 PubMed GONUTS page

[PMID:15772132-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Thorpe, CJ et al. (2005) Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development 132 1763-72 PubMed GONUTS page

[PMID:15703279-15] 15.0 ^15.1 Rhinn, M et al. (2005) Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development 132 1261-72 PubMed GONUTS page

[PMID:15797017-16] 16.0 ^16.1 Weidinger, G et al. (2005) The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr. Biol. 15 489-500 PubMed GONUTS page

[PMID:19341460-17] Rhinn, M et al. (2009) Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal. Neural Dev 4 12 PubMed GONUTS page

[PMID:26041917-18] 18.0 ^18.1 Ma, Y et al. (2015) The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. J. Neurosci. 35 8493-506 PubMed GONUTS page

[PMID:11566861-19] 19.0 ^19.1 ^19.2 Erter, CE et al. (2001) Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development 128 3571-83 PubMed GONUTS page

[PMID:17510365-20] 20.0 ^20.1 Major, MB et al. (2007) Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 316 1043-6 PubMed GONUTS page

[PMID:21282610-21] 21.0 ^21.1 ^21.2 ^21.3 Li, Z et al. (2011) Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc. Natl. Acad. Sci. U.S.A. 108 3116-23 PubMed GONUTS page

[PMID:9753682-22] 22.0 ^22.1 Nasevicius, A et al. (1998) Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation. Development 125 4283-92 PubMed GONUTS page

[PMID:15269175-23] 23.0 ^23.1 Ramel, MC & Lekven, AC (2004) Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development 131 3991-4000 PubMed GONUTS page

[PMID:29208373-24] 24.0 ^24.1 ^24.2 ^24.3 Hino, H et al. (2018) Roles of maternal wnt8a transcripts in axis formation in zebrafish. Dev. Biol. 434 96-107 PubMed GONUTS page

[PMID:16547521-25] Angers, S et al. (2006) The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 8 348-57 PubMed GONUTS page

[PMID:15366022-26] Ramel, MC et al. (2004) Conservation of structure and functional divergence of duplicated Wnt8s in pufferfish. Dev. Dyn. 231 441-8 PubMed GONUTS page

[PMID:11703928-27] 27.0 ^27.1 ^27.2 Lekven, AC et al. (2001) Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev. Cell 1 103-14 PubMed GONUTS page

[PMID:19572019-28] Kategaya, LS et al. (2009) Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS ONE 4 e6129 PubMed GONUTS page

[PMID:19471023-29] James, RG et al. (2009) Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal 2 ra25 PubMed GONUTS page

[PMID:18585699-30] Goessling, W et al. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev. Biol. 320 161-74 PubMed GONUTS page

[PMID:15708563-31] Shimizu, T et al. (2005) Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev. Biol. 279 125-41 PubMed GONUTS page

[PMID:15240553-32] Szeto, DP & Kimelman, D (2004) Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development 131 3751-60 PubMed GONUTS page

[PMID:21873635-33] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:WNT8A

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