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PMID:19341460

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Citation

Rhinn, M, Lun, K, Ahrendt, R, Geffarth, M and Brand, M (2009) Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal. Neural Dev 4:12

Abstract

Studies in mouse, Xenopus and chicken have shown that Otx2 and Gbx2 expression domains are fundamental for positioning the midbrain-hindbrain boundary (MHB) organizer. Of the two zebrafish gbx genes, gbx1 is a likely candidate to participate in this event because its early expression is similar to that reported for Gbx2 in other species. Zebrafish gbx2, on the other hand, acts relatively late at the MHB. To investigate the function of zebrafish gbx1 within the early neural plate, we used a combination of gain- and loss-of-function experiments.

Links

PubMed PMC2674439 Online version:10.1186/1749-8104-4-12

Keywords

Animals; Body Patterning/genetics; Brain Stem/cytology; Brain Stem/embryology; Brain Stem/metabolism; Cell Differentiation/genetics; Cell Lineage/genetics; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/metabolism; Down-Regulation/genetics; Gene Expression Regulation, Developmental/genetics; Genes, Homeobox/genetics; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Mesencephalon/cytology; Mesencephalon/embryology; Mesencephalon/metabolism; Molecular Biology/methods; Mutation/genetics; Neural Tube/cytology; Neural Tube/embryology; Neural Tube/metabolism; Otx Transcription Factors/genetics; Otx Transcription Factors/metabolism; Rhombencephalon/cytology; Rhombencephalon/embryology; Rhombencephalon/metabolism; Signal Transduction/genetics; Transcriptional Activation/genetics; Wnt Proteins/genetics; Wnt Proteins/metabolism; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:Q90ZB2

involved_in

GO:0021555: midbrain-hindbrain boundary morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100429-4

P

Seeded From UniProt

complete

DANRE:Q90ZB2

involved_in

GO:0021555: midbrain-hindbrain boundary morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100429-3

P

Seeded From UniProt

complete

DANRE:Q90ZB2

involved_in

GO:0060827: regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-041217-12

P

Seeded From UniProt

complete

DANRE:WNT8A

involved_in

GO:0030902: hindbrain development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-041217-12

P

Seeded From UniProt

complete


See also

References

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