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PMID:16854974

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Citation

Peng, G and Westerfield, M (2006) Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development 133:3191-200

Abstract

In vertebrate embryos, induction and patterning of the forebrain require the local inhibition of caudalizing signals, such as Wnts, emanating from the mesendoderm and caudal brain. Here, we report that Lhx5, expressed in the rostral neuroectoderm, regulates the local inhibition of Wnts. Activation of Lhx5 expands forebrain structures, whereas inhibition of Lhx5 function compromises forebrain development in zebrafish embryos. Lhx5 can rescue forebrain deficiencies caused by excess Wnt activity, and inhibition of Lhx5 function results in ectopic activation of Wnt signaling. Lhx5 regulates the expression of two secreted Frizzled-related Wnt antagonists, Sfrp1a and Sfrp5. These Sfrps can reduce the ectopic activation of Wnt signaling and rescue the forebrain deficiencies caused by inhibition of Lhx5 function. Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists.

Links

PubMed Online version:10.1242/dev.02485

Keywords

Animals; Axin Protein; Gene Expression Regulation, Developmental; Homeodomain Proteins/genetics; Homeodomain Proteins/physiology; Intercellular Signaling Peptides and Proteins/genetics; LIM-Homeodomain Proteins; Prosencephalon/embryology; Repressor Proteins/genetics; Repressor Proteins/metabolism; Trans-Activators/genetics; Trans-Activators/physiology; Transcription Factors; Transcription, Genetic; Wnt Proteins/antagonists & inhibitors; Zebrafish/embryology; Zebrafish/genetics; Zebrafish Proteins/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A0B5JK22

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:B0V369

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:F1QJG6

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:F1QJG6

involved_in

GO:0030900: forebrain development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:LHX5

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-020715-4

P

Seeded From UniProt

complete

DANRE:LHX5

involved_in

GO:0030900: forebrain development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:LHX5

involved_in

GO:0030900: forebrain development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-061117-1

P

Seeded From UniProt

complete

DANRE:AXIN1

involved_in

GO:0001654: eye development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-020715-4

P

Seeded From UniProt

complete

DANRE:AXIN1

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-020715-4

P

Seeded From UniProt

complete

DANRE:Q32PN6

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:Q568X0

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:Q6YNR8

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:Q6YNR8

involved_in

GO:0030900: forebrain development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q7T2K9

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:Q90ZG8

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

DANRE:Q90ZG8

involved_in

GO:0030900: forebrain development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:WNT8A

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-040310-5

P

Seeded From UniProt

complete

DANRE:WNT8A

involved_in

GO:0001654: eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-011108-2

P

Seeded From UniProt

complete

DANRE:WNT8A

GO:0001654: eye development

ECO:0000316:

ZFIN:ZDB-GENE-040310-5

P

complete

DANRE:WNT8A

involved_in

GO:0001654: eye development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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