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HUMAN:WNT11
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | WNT11 | |
Protein Name(s) | Protein Wnt-11 | |
External Links | ||
UniProt | O96014 | |
EMBL | Y13843 Y13844 Y13845 Y13846 Y13847 Y12692 AB070218 AK313570 BC074790 BC074791 BC113386 BC113388 | |
CCDS | CCDS8242.1 | |
RefSeq | NP_004617.2 XP_005274288.1 | |
UniGene | Hs.108219 | |
ProteinModelPortal | O96014 | |
SMR | O96014 | |
BioGrid | 113318 | |
IntAct | O96014 | |
MINT | MINT-7003207 | |
STRING | 9606.ENSP00000325526 | |
PhosphoSite | O96014 | |
PaxDb | O96014 | |
PRIDE | O96014 | |
DNASU | 7481 | |
Ensembl | ENST00000322563 | |
GeneID | 7481 | |
KEGG | hsa:7481 | |
UCSC | uc001oxe.3 | |
CTD | 7481 | |
GeneCards | GC11M075897 | |
HGNC | HGNC:12776 | |
HPA | HPA050101 | |
MIM | 603699 | |
neXtProt | NX_O96014 | |
PharmGKB | PA37378 | |
eggNOG | NOG273917 | |
GeneTree | ENSGT00760000118943 | |
HOGENOM | HOG000039529 | |
HOVERGEN | HBG001595 | |
InParanoid | O96014 | |
KO | K01384 | |
OMA | ELIYLQS | |
OrthoDB | EOG7C8GJ8 | |
PhylomeDB | O96014 | |
TreeFam | TF105310 | |
Reactome | REACT_163710 REACT_172581 REACT_172761 REACT_18372 | |
GeneWiki | WNT11 | |
GenomeRNAi | 7481 | |
NextBio | 29304 | |
PRO | PR:O96014 | |
Proteomes | UP000005640 | |
Bgee | O96014 | |
CleanEx | HS_WNT11 | |
ExpressionAtlas | O96014 | |
Genevestigator | O96014 | |
GO | GO:0005737 GO:0005576 GO:0005615 GO:0005578 GO:0005109 GO:0030295 GO:0005099 GO:0044212 GO:0030325 GO:0048844 GO:0030282 GO:0060070 GO:0045165 GO:0071300 GO:0060197 GO:0048706 GO:0060484 GO:0072177 GO:0043066 GO:0090090 GO:0061037 GO:0060548 GO:0030308 GO:0030336 GO:0090272 GO:0072201 GO:0045892 GO:0061101 GO:0030182 GO:0035567 GO:0001649 GO:0003151 GO:0060021 GO:0043065 GO:0030335 GO:0010628 GO:0045860 GO:0090037 GO:0032320 GO:0051496 GO:0045893 GO:0032915 GO:0034394 GO:0006468 GO:0031667 GO:0070830 GO:0060675 GO:0060412 | |
InterPro | IPR005817 IPR026536 IPR018161 | |
PANTHER | PTHR12027 PTHR12027:SF7 | |
Pfam | PF00110 | |
PRINTS | PR01349 | |
SMART | SM00097 | |
PROSITE | PS00246 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0009653 |
anatomical structure morphogenesis |
ECO:0000304 |
P |
Source: ProtInc |
Missing: reference | |||||
GO:0007165 |
signal transduction |
ECO:0000303 |
P |
Source: ProtInc |
Missing: reference | |||||
involved_in |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005109 |
frizzled binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
part_of:(GO:0007223)|part_of:(GO:0060071) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007223 |
Wnt signaling pathway, calcium modulating pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0062009 |
secondary palate development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090037 |
positive regulation of protein kinase C signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072177 |
mesonephric duct development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071300 |
cellular response to retinoic acid |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061101 |
neuroendocrine cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061037 |
negative regulation of cartilage development |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060675 |
ureteric bud morphogenesis |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060484 |
lung-associated mesenchyme development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060197 |
cloacal septation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051496 |
positive regulation of stress fiber assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048706 |
embryonic skeletal system development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034394 |
protein localization to cell surface |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030325 |
adrenal gland development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030295 |
protein kinase activator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030295 |
protein kinase activator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045165 |
cell fate commitment |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98957 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000246517 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010194 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005109 |
frizzled binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004009 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030295 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030295 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V819 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V819 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090272 |
negative regulation of fibroblast growth factor production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072201 |
negative regulation of mesenchymal cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071260 |
cellular response to mechanical stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070830 |
bicellular tight junction assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061053 |
somite development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060775 |
planar cell polarity pathway involved in gastrula mediolateral intercalation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060412 |
ventricular septum morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060070 |
canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060028 |
convergent extension involved in axis elongation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060021 |
roof of mouth development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048844 |
artery morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048570 |
notochord morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048341 |
paraxial mesoderm formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045199 |
maintenance of epithelial cell apical/basal polarity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035567 |
non-canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032915 |
positive regulation of transforming growth factor beta2 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030282 |
bone mineralization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003402 |
planar cell polarity pathway involved in axis elongation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003151 |
outflow tract morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001837 |
epithelial to mesenchymal transition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001822 |
kidney development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001649 |
osteoblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48615 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060071 |
Wnt signaling pathway, planar cell polarity pathway |
Reactome:R-HSA-4086400 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016055 |
Wnt signaling pathway |
Reactome:R-HSA-195721 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-3858482 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
- ↑ Chiquet, BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum. Mol. Genet. 17 2212-8 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Toyama, T et al. (2010) Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. Mol. Cancer Res. 8 254-65 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Lako, M et al. (1998) Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. Gene 219 101-10 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Uysal-Onganer, P et al. (2010) Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol. Cancer 9 55 PubMed GONUTS page
- ↑ 6.0 6.1 Pizzatti, L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49 107-18 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
- GO:0060070 ! canonical Wnt signaling pathway
- Catarrhini
- GO:0071260 ! cellular response to mechanical stimulus
- GO:0071300 ! cellular response to retinoic acid
- GO:0030154 ! cell differentiation
- GO:0045165 ! cell fate commitment
- Chordata
- GO:0060197 ! cloacal septation
- GO:0060028 ! convergent extension involved in axis elongation
- Craniata
- GO:0005737 ! cytoplasm
e
m
n
- GO:0072201 ! negative regulation of mesenchymal cell proliferation
- GO:0043066 ! negative regulation of apoptotic process
- GO:0090090 ! negative regulation of canonical Wnt signaling pathway
- GO:0061037 ! negative regulation of cartilage development
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0090272 ! negative regulation of fibroblast growth factor production
- GO:0030308 ! negative regulation of cell growth
- GO:0030336 ! negative regulation of cell migration
- GO:0061101 ! neuroendocrine cell differentiation
- GO:0030182 ! neuron differentiation
- GO:0035567 ! non-canonical Wnt signaling pathway
- GO:0048570 ! notochord morphogenesis
o
- GO:0060548 ! obsolete negative regulation of cell death
- GO:0003402 ! obsolete planar cell polarity pathway involved in axis elongation
- GO:0060775 ! obsolete planar cell polarity pathway involved in gastrula mediolateral intercalation
- GO:0001649 ! osteoblast differentiation
- GO:0003151 ! outflow tract morphogenesis
p
- GO:0048341 ! paraxial mesoderm formation
- GO:0090037 ! positive regulation of protein kinase C signaling
- GO:0043065 ! positive regulation of apoptotic process
- GO:0043547 ! positive regulation of GTPase activity
- GO:0010628 ! positive regulation of gene expression
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0051496 ! positive regulation of stress fiber assembly
- GO:0030335 ! positive regulation of cell migration
- GO:0032915 ! positive regulation of transforming growth factor beta2 production
- Primates
- GO:0030295 ! protein kinase activator activity
- GO:0034394 ! protein localization to cell surface
- GO:0006468 ! protein phosphorylation
s