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HUMAN:WNT11

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) WNT11
Protein Name(s) Protein Wnt-11
External Links
UniProt O96014
EMBL Y13843
Y13844
Y13845
Y13846
Y13847
Y12692
AB070218
AK313570
BC074790
BC074791
BC113386
BC113388
CCDS CCDS8242.1
RefSeq NP_004617.2
XP_005274288.1
UniGene Hs.108219
ProteinModelPortal O96014
SMR O96014
BioGrid 113318
IntAct O96014
MINT MINT-7003207
STRING 9606.ENSP00000325526
PhosphoSite O96014
PaxDb O96014
PRIDE O96014
DNASU 7481
Ensembl ENST00000322563
GeneID 7481
KEGG hsa:7481
UCSC uc001oxe.3
CTD 7481
GeneCards GC11M075897
HGNC HGNC:12776
HPA HPA050101
MIM 603699
neXtProt NX_O96014
PharmGKB PA37378
eggNOG NOG273917
GeneTree ENSGT00760000118943
HOGENOM HOG000039529
HOVERGEN HBG001595
InParanoid O96014
KO K01384
OMA ELIYLQS
OrthoDB EOG7C8GJ8
PhylomeDB O96014
TreeFam TF105310
Reactome REACT_163710
REACT_172581
REACT_172761
REACT_18372
GeneWiki WNT11
GenomeRNAi 7481
NextBio 29304
PRO PR:O96014
Proteomes UP000005640
Bgee O96014
CleanEx HS_WNT11
ExpressionAtlas O96014
Genevestigator O96014
GO GO:0005737
GO:0005576
GO:0005615
GO:0005578
GO:0005109
GO:0030295
GO:0005099
GO:0044212
GO:0030325
GO:0048844
GO:0030282
GO:0060070
GO:0045165
GO:0071300
GO:0060197
GO:0048706
GO:0060484
GO:0072177
GO:0043066
GO:0090090
GO:0061037
GO:0060548
GO:0030308
GO:0030336
GO:0090272
GO:0072201
GO:0045892
GO:0061101
GO:0030182
GO:0035567
GO:0001649
GO:0003151
GO:0060021
GO:0043065
GO:0030335
GO:0010628
GO:0045860
GO:0090037
GO:0032320
GO:0051496
GO:0045893
GO:0032915
GO:0034394
GO:0006468
GO:0031667
GO:0070830
GO:0060675
GO:0060412
InterPro IPR005817
IPR026536
IPR018161
PANTHER PTHR12027
PTHR12027:SF7
Pfam PF00110
PRINTS PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009653

anatomical structure morphogenesis

ECO:0000304

P

Source: ProtInc

Missing: reference

GO:0007165

signal transduction

ECO:0000303

P

Source: ProtInc

Missing: reference

involved_in

GO:0060071

Wnt signaling pathway, planar cell polarity pathway

PMID:24431302[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:24431302[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

part_of:(GO:0007223)|part_of:(GO:0060071)

Seeded From UniProt

complete

involved_in

GO:0007223

Wnt signaling pathway, calcium modulating pathway

PMID:24431302[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0062009

secondary palate development

PMID:18413325[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090037

positive regulation of protein kinase C signaling

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072177

mesonephric duct development

PMID:9757009[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071300

cellular response to retinoic acid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0061101

neuroendocrine cell differentiation

PMID:20219091[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061037

negative regulation of cartilage development

PMID:9757009[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060675

ureteric bud morphogenesis

PMID:9757009[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

PMID:20219091[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060484

lung-associated mesenchyme development

PMID:9757009[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060197

cloacal septation

PMID:9757009[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051496

positive regulation of stress fiber assembly

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048706

embryonic skeletal system development

PMID:9757009[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:19847889[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:20219091[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:19847889[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:20219091[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034394

protein localization to cell surface

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:20219091[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030325

adrenal gland development

PMID:9757009[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030295

protein kinase activator activity

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030295

protein kinase activator activity

PMID:20219091[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P56706

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:20219091[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20103596[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20219091[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:20103596[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98957
PANTHER:PTN000246517
UniProtKB:P49339
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000246517
RGD:69250
UniProtKB:P56706
UniProtKB:Q98SN7

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010194
MGI:MGI:108061
MGI:MGI:1197020
MGI:MGI:98953
MGI:MGI:98954
MGI:MGI:98956
MGI:MGI:98958
MGI:MGI:98960
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
UniProtKB:P41221
UniProtKB:Q98SN7
WB:WBGene00000858
WB:WBGene00003029
ZFIN:ZDB-GENE-980526-332

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
MGI:MGI:98956
MGI:MGI:98957
PANTHER:PTN000246517
RGD:1311441
RGD:69250
UniProtKB:P41221
UniProtKB:P56704
UniProtKB:P56705
UniProtKB:Q2LMP1
UniProtKB:Q9UBV4
UniProtKB:Q9YGX6

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004009
FB:FBgn0004360
FB:FBgn0010453
FB:FBgn0038134
MGI:MGI:98956
MGI:MGI:98957
MGI:MGI:98958
MGI:MGI:98961
MGI:MGI:98962
PANTHER:PTN000246517
RGD:69079
UniProtKB:P09544
UniProtKB:P41221
UniProtKB:P56703
UniProtKB:Q98SN7

F

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030295

P

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030295

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V819
ensembl:ENSRNOP00000021674

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V819
ensembl:ENSRNOP00000021674

P

Seeded From UniProt

complete

involved_in

GO:0090272

negative regulation of fibroblast growth factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0072201

negative regulation of mesenchymal cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0071260

cellular response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0070830

bicellular tight junction assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0061053

somite development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0060775

planar cell polarity pathway involved in gastrula mediolateral intercalation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0060412

ventricular septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0060028

convergent extension involved in axis elongation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0060021

roof of mouth development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0048844

artery morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0048570

notochord morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0048341

paraxial mesoderm formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0045199

maintenance of epithelial cell apical/basal polarity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0035567

non-canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0032915

positive regulation of transforming growth factor beta2 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

C

Seeded From UniProt

complete

involved_in

GO:0030282

bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

C

Seeded From UniProt

complete

involved_in

GO:0003402

planar cell polarity pathway involved in axis elongation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0003151

outflow tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48615
ensembl:ENSMUSP00000064333

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

P

Seeded From UniProt

complete

involved_in

GO:0060071

Wnt signaling pathway, planar cell polarity pathway

Reactome:R-HSA-4086400

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

Reactome:R-HSA-195721

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-3858482
Reactome:R-HSA-3247843

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
  2. Chiquet, BT et al. (2008) Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum. Mol. Genet. 17 2212-8 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Toyama, T et al. (2010) Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. Mol. Cancer Res. 8 254-65 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Lako, M et al. (1998) Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. Gene 219 101-10 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Uysal-Onganer, P et al. (2010) Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol. Cancer 9 55 PubMed GONUTS page
  6. 6.0 6.1 Pizzatti, L et al. (2010) SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer 49 107-18 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page