MOUSE:DVL2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dvl2
Protein Name(s)	Segment polarity protein dishevelled homolog DVL-2 Dishevelled-2 DSH homolog 2
External Links
UniProt	Q60838
EMBL	U24160 AK146822 AK159895 AK168376 AL596185 CH466596 BC053050
CCDS	CCDS24930.1
RefSeq	NP_031914.3
UniGene	Mm.5114
PDB	3ML6
PDBsum	3ML6
ProteinModelPortal	Q60838
SMR	Q60838
BioGrid	199343
DIP	DIP-29399N
IntAct	Q60838
MINT	MINT-1591968
PhosphoSite	Q60838
MaxQB	Q60838
PaxDb	Q60838
PRIDE	Q60838
Ensembl	ENSMUST00000019362 ENSMUST00000102575 ENSMUST00000190940
GeneID	13543
KEGG	mmu:13543
UCSC	uc007jtm.1
CTD	1856
MGI	MGI:106613
eggNOG	NOG322275
GeneTree	ENSGT00390000013552
HOGENOM	HOG000017084
HOVERGEN	HBG005542
InParanoid	Q60838
KO	K02353
OMA	SFHLAMG
OrthoDB	EOG7BP82N
TreeFam	TF318198
Reactome	REACT_196537 REACT_203973 REACT_207044 REACT_214043 REACT_216784 REACT_222404 REACT_225118 REACT_227429 REACT_256730
ChiTaRS	Dvl2
NextBio	284146
PRO	PR:Q60838
Proteomes	UP000000589
Bgee	Q60838
CleanEx	MM_DVL2
ExpressionAtlas	Q60838
Genevestigator	Q60838
GO	GO:0045177 GO:0005938 GO:0030136 GO:0005737 GO:0031410 GO:0005856 GO:0005829 GO:0005634 GO:0005886 GO:0005109 GO:0042802 GO:0019904 GO:0043621 GO:0060070 GO:0044340 GO:0021535 GO:0034613 GO:0090103 GO:0022007 GO:0060029 GO:0007507 GO:0003007 GO:0035556 GO:0001843 GO:0003151 GO:0090179 GO:0090263 GO:0043507 GO:0061098 GO:0051091 GO:0045893 GO:0046328 GO:0007379 GO:0035282 GO:0006366 GO:0016055 GO:0060071
Gene3D	1.10.10.10 2.30.42.10
InterPro	IPR000591 IPR024580 IPR008339 IPR003351 IPR001158 IPR015506 IPR008341 IPR001478 IPR029071 IPR011991
PANTHER	PTHR10878 PTHR10878:SF8
Pfam	PF00610 PF02377 PF00778 PF12316 PF00595
PRINTS	PR01760 PR01762
SMART	SM00021 SM00049 SM00228
SUPFAM	SSF50156 SSF54236
PROSITE	PS50186 PS50841 PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:17244647^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17244647^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49674	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17244647^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9JMK2	F		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:18093802^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:23109420^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P63001) has_input:(UniProtKB:Q60610)	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:23109420^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P63001)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:23109420^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:23109420^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:23109420^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:10829020^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035282	segmentation	PMID:8887313^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51140	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:8856345^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:12464179^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21189423^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:21189423^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20534871^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21189423^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19465938^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19465938^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:20802536^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9ULV1	F		Seeded From UniProt	complete
involved_in	GO:0090179	planar cell polarity pathway involved in neural tube closure	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106613 MGI:MGI:108100 MGI:MGI:94941 PANTHER:PTN000853715	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000499 MGI:MGI:106613 MGI:MGI:108100 MGI:MGI:2679721 MGI:MGI:94941 PANTHER:PTN000093945 UniProtKB:O14640 UniProtKB:O14641 UniProtKB:Q92997 ZFIN:ZDB-GENE-030721-2	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106613 PANTHER:PTN000093945 UniProtKB:Q155Q3 UniProtKB:Q92997	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106613 PANTHER:PTN000093831 UniProtKB:O14640 UniProtKB:O14641 UniProtKB:Q92997	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090179	planar cell polarity pathway involved in neural tube closure	PMID:16571627^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135272 MGI:MGI:94941	P	occurs_in:(EMAPA:16164)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090179	planar cell polarity pathway involved in neural tube closure	PMID:16571627^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429760	P	occurs_in:(EMAPA:16164)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	PMID:19008950^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108100	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	PMID:16116426^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:19920076^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:16116426^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94941	P	occurs_in:(EMAPA:19151) occurs_in:(CL:0000202)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:17606995^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1351660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:10409711^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19008950^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429760	P	occurs_in:(EMAPA:16405)\|occurs_in:(EMAPA:16184)\|occurs_in:(EMAPA:16860)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:8887313^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:18606138^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060029	convergent extension involved in organogenesis	PMID:16116426^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94941	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:19300477^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17021) part_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035567	non-canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034613	cellular protein localization	PMID:17606995^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:23209302^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	C		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	PMID:17005174^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022007	convergent extension involved in neural plate elongation	PMID:16571627^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2135272 MGI:MGI:94941	P	has_participant:(EMAPA:16164)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022007	convergent extension involved in neural plate elongation	PMID:16571627^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429760	P	has_participant:(EMAPA:16164)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:15579909^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35625	F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:23533177^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000589) part_of:(EMAPA:17597)	Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:12464179^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429760	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:12421720^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429760	P	results_in_development_of:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007379	segment specification	PMID:12421720^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429760	P	has_participant:(EMAPA:16184)\|has_participant:(EMAPA:16414)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:10330403^[26]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51142	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17606995^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17005174^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16571627^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16164) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16116426^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19151) part_of:(CL:0000202)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23580654^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17606995^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23209302^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10330403^[26]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51142	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:19008950^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108100	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:12421720^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429760	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21189423^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60838	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17529994^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60838	F		Seeded From UniProt	complete
involved_in	GO:0150012	positive regulation of neuron projection arborization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZB71 ensembl:ENSRNOP00000024348	P		Seeded From UniProt	complete
involved_in	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
involved_in	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	F		Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	C		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	C		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14641 ensembl:ENSP00000005340	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008339 InterPro:IPR008341 InterPro:IPR015506	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000591	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Bryja, V et al. (2007) Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell. Sci. 120 586-95 PubMed GONUTS page
↑ Lee, YN et al. (2008) Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell. Signal. 20 443-52 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Čajánek, L et al. (2013) Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol. Cell. Biol. 33 59-70 PubMed GONUTS page
↑ Zhang, Y et al. (2000) Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 275 25008-14 PubMed GONUTS page
↑ ^5.0 ^5.1 Klingensmith, J et al. (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech. Dev. 58 15-26 PubMed GONUTS page
↑ Steitz, SA et al. () Wnt-mediated relocalization of dishevelled proteins. In Vitro Cell. Dev. Biol. Anim. 32 441-5 PubMed GONUTS page
↑ ^7.0 ^7.1 Kioussi, C et al. (2002) Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111 673-85 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Liu, YT et al. (2011) Molecular basis of Wnt activation via the DIX domain protein Ccd1. J. Biol. Chem. 286 8597-608 PubMed GONUTS page
↑ Babayeva, S et al. (2011) Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am. J. Physiol. Renal Physiol. 300 F549-60 PubMed GONUTS page
↑ ^10.0 ^10.1 Bouteille, N et al. (2009) Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene 28 2569-80 PubMed GONUTS page
↑ Wheeler, DS et al. (2011) Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling. Oncogene 30 32-42 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Wang, J et al. (2006) Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development 133 1767-78 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Etheridge, SL et al. (2008) Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet. 4 e1000259 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Wang, J et al. (2005) Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat. Genet. 37 980-5 PubMed GONUTS page
↑ Yokoyama, N & Malbon, CC (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J. Cell. Sci. 122 4439-51 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Schwarz-Romond, T et al. (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J. Cell. Sci. 120 2402-12 PubMed GONUTS page
↑ Lee, JS et al. (1999) Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J. Biol. Chem. 274 21464-70 PubMed GONUTS page
↑ Yamamoto, S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15 23-36 PubMed GONUTS page
↑ Matsuyama, M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 5 e1000427 PubMed GONUTS page
↑ ^21.0 ^21.1 Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
↑ ^22.0 ^22.1 Na, J et al. (2007) Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Dev. Biol. 302 40-9 PubMed GONUTS page
↑ Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page
↑ Sipe, CW et al. (2013) Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development 140 1785-95 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Hamblet, NS et al. (2002) Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129 5827-38 PubMed GONUTS page
↑ ^26.0 ^26.1 Fagotto, F et al. (1999) Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J. Cell Biol. 145 741-56 PubMed GONUTS page
↑ Xue, H et al. (2013) Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling. J. Biol. Chem. 288 15006-14 PubMed GONUTS page
↑ Schwarz-Romond, T et al. (2007) The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nat. Struct. Mol. Biol. 14 484-92 PubMed GONUTS page

[PMID:17244647-1] 1.0 ^1.1 ^1.2 Bryja, V et al. (2007) Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell. Sci. 120 586-95 PubMed GONUTS page

[PMID:18093802-2] Lee, YN et al. (2008) Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell. Signal. 20 443-52 PubMed GONUTS page

[PMID:23109420-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Čajánek, L et al. (2013) Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol. Cell. Biol. 33 59-70 PubMed GONUTS page

[PMID:10829020-4] Zhang, Y et al. (2000) Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 275 25008-14 PubMed GONUTS page

[PMID:8887313-5] 5.0 ^5.1 Klingensmith, J et al. (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech. Dev. 58 15-26 PubMed GONUTS page

[PMID:8856345-6] Steitz, SA et al. () Wnt-mediated relocalization of dishevelled proteins. In Vitro Cell. Dev. Biol. Anim. 32 441-5 PubMed GONUTS page

[PMID:12464179-7] 7.0 ^7.1 Kioussi, C et al. (2002) Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111 673-85 PubMed GONUTS page

[PMID:21189423-8] 8.0 ^8.1 ^8.2 ^8.3 Liu, YT et al. (2011) Molecular basis of Wnt activation via the DIX domain protein Ccd1. J. Biol. Chem. 286 8597-608 PubMed GONUTS page

[PMID:20534871-9] Babayeva, S et al. (2011) Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am. J. Physiol. Renal Physiol. 300 F549-60 PubMed GONUTS page

[PMID:19465938-10] 10.0 ^10.1 Bouteille, N et al. (2009) Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene 28 2569-80 PubMed GONUTS page

[PMID:20802536-11] Wheeler, DS et al. (2011) Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling. Oncogene 30 32-42 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16571627-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Wang, J et al. (2006) Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development 133 1767-78 PubMed GONUTS page

[PMID:19008950-14] 14.0 ^14.1 ^14.2 Etheridge, SL et al. (2008) Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet. 4 e1000259 PubMed GONUTS page

[PMID:16116426-15] 15.0 ^15.1 ^15.2 ^15.3 Wang, J et al. (2005) Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat. Genet. 37 980-5 PubMed GONUTS page

[PMID:19920076-16] Yokoyama, N & Malbon, CC (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J. Cell. Sci. 122 4439-51 PubMed GONUTS page

[PMID:17606995-17] 17.0 ^17.1 ^17.2 ^17.3 Schwarz-Romond, T et al. (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J. Cell. Sci. 120 2402-12 PubMed GONUTS page

[PMID:10409711-18] Lee, JS et al. (1999) Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J. Biol. Chem. 274 21464-70 PubMed GONUTS page

[PMID:18606138-19] Yamamoto, S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15 23-36 PubMed GONUTS page

[PMID:19300477-20] Matsuyama, M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 5 e1000427 PubMed GONUTS page

[PMID:23209302-21] 21.0 ^21.1 Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page

[PMID:17005174-22] 22.0 ^22.1 Na, J et al. (2007) Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Dev. Biol. 302 40-9 PubMed GONUTS page

[PMID:15579909-23] Luo, W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J. Biol. Chem. 280 5054-60 PubMed GONUTS page

[PMID:23533177-24] Sipe, CW et al. (2013) Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development 140 1785-95 PubMed GONUTS page

[PMID:12421720-25] 25.0 ^25.1 ^25.2 Hamblet, NS et al. (2002) Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129 5827-38 PubMed GONUTS page

[PMID:10330403-26] 26.0 ^26.1 Fagotto, F et al. (1999) Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J. Cell Biol. 145 741-56 PubMed GONUTS page

[PMID:23580654-27] Xue, H et al. (2013) Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling. J. Biol. Chem. 288 15006-14 PubMed GONUTS page

[PMID:17529994-28] Schwarz-Romond, T et al. (2007) The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nat. Struct. Mol. Biol. 14 484-92 PubMed GONUTS page

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