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PMID:16116426

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Citation

Wang, J, Mark, S, Zhang, X, Qian, D, Yoo, SJ, Radde-Gallwitz, K, Zhang, Y, Lin, X, Collazo, A, Wynshaw-Boris, A and Chen, P (2005) Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat. Genet. 37:980-5

Abstract

The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity (PCP) parallel to the sensory epithelium. It is not certain how this polarity is achieved during differentiation. Here we show that the organ of Corti is formed from a thicker and shorter postmitotic primordium through unidirectional extension, characteristic of cellular intercalation known as convergent extension. Mutations in the PCP pathway interfere with this extension, resulting a shorter and wider cochlea as well as misorientation of stereocilia. Furthermore, parallel to the homologous pathway in Drosophila melanogaster, a mammalian PCP component Dishevelled2 shows PCP-dependent polarized subcellular localization across the organ of Corti. Taken together, these data suggest that there is a conserved molecular mechanism for PCP pathways in invertebrates and vertebrates and indicate that the mammalian PCP pathway might directly couple cellular intercalations to PCP establishment in the cochlea.

Links

PubMed PMC1413588 Online version:10.1038/ng1622

Keywords

Adaptor Proteins, Signal Transducing; Animals; Cell Polarity; Cochlea/physiology; Female; Male; Mice; Mice, Knockout; Mutation; Organ of Corti; Phosphoproteins; Pregnancy; Proteins/physiology; Signal Transduction; Subcellular Fractions; Vertebrates

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:DVL1

involved_in

GO:0090103: cochlea morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:106613

P

Seeded From UniProt

complete

MOUSE:DVL1

involved_in

GO:0060029: convergent extension involved in organogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:106613

P

Seeded From UniProt

complete

MOUSE:DVL1

involved_in

GO:0060071: Wnt signaling pathway, planar cell polarity pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:106613

P

Seeded From UniProt

complete

MOUSE:DVL1

involved_in

GO:0060029: convergent extension involved in organogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137230

P

Seeded From UniProt

complete

MOUSE:DVL1

involved_in

GO:0060071: Wnt signaling pathway, planar cell polarity pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137230

P

Seeded From UniProt

complete

MOUSE:DVL2

located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:DVL2

involved_in

GO:0090103: cochlea morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94941

P

Seeded From UniProt

complete

MOUSE:DVL2

involved_in

GO:0060029: convergent extension involved in organogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94941

P

Seeded From UniProt

complete

MOUSE:DVL2

involved_in

GO:0060071: Wnt signaling pathway, planar cell polarity pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94941

P

Seeded From UniProt

complete

MOUSE:VANG2

involved_in

GO:0090103: cochlea morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857642

P

Seeded From UniProt

complete

MOUSE:VANG2

involved_in

GO:0060071: Wnt signaling pathway, planar cell polarity pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857642

P

Seeded From UniProt

complete

MOUSE:DVL2

part_of

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:19151)
  • part_of:(CL:0000202)

Seeded From UniProt

complete

MOUSE:DVL2

acts_upstream_of_or_within

GO:0060029: convergent extension involved in organogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94941

P

Seeded From UniProt

complete

MOUSE:DVL2

acts_upstream_of_or_within

GO:0060071: Wnt signaling pathway, planar cell polarity pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94941

P

  • occurs_in:(EMAPA:19151)
  • occurs_in:(CL:0000202)

Seeded From UniProt

complete

MOUSE:DVL2

acts_upstream_of_or_within

GO:0090103: cochlea morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:94941

P

Seeded From UniProt

complete


See also

References

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