MOUSE:WNT11

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wnt11 (synonyms: Wnt-11)
Protein Name(s)	Protein Wnt-11
External Links
UniProt	P48615
EMBL	X70800
CCDS	CCDS21475.1
PIR	S34378
RefSeq	NP_001272721.1 NP_033545.1 XP_006507649.1
UniGene	Mm.22182
ProteinModelPortal	P48615
SMR	P48615
BioGrid	204570
STRING	10090.ENSMUSP00000064333
PhosphoSite	P48615
MaxQB	P48615
PRIDE	P48615
GeneID	22411
KEGG	mmu:22411
UCSC	uc009ikv.3
CTD	7481
MGI	MGI:101948
eggNOG	NOG273917
HOGENOM	HOG000039529
HOVERGEN	HBG001595
InParanoid	P48615
KO	K01384
OMA	ELIYLQS
PhylomeDB	P48615
TreeFam	TF105310
Reactome	R-MMU-3238698 R-MMU-4086398 R-MMU-4086400
NextBio	302813
PRO	PR:P48615
Proteomes	UP000000589
Bgee	P48615
CleanEx	MM_WNT11
ExpressionAtlas	P48615
Genevisible	P48615
GO	GO:0005737 GO:0005576 GO:0005615 GO:0005578 GO:0005109 GO:0005096 GO:0030295 GO:0005102 GO:0044212 GO:0032147 GO:0030325 GO:0048844 GO:0070830 GO:0030282 GO:0060070 GO:0045165 GO:0007267 GO:0060197 GO:0060028 GO:0048706 GO:0001837 GO:0001822 GO:0060484 GO:0045199 GO:0072177 GO:0043066 GO:0090090 GO:0060548 GO:0030308 GO:0030336 GO:0090272 GO:0072201 GO:0045892 GO:0061101 GO:0030182 GO:0035567 GO:0048570 GO:0009887 GO:0001649 GO:0003151 GO:0060021 GO:0048341 GO:0003402 GO:0060775 GO:0043065 GO:0030335 GO:0010628 GO:0043547 GO:0090037 GO:0051496 GO:0045893 GO:0032915 GO:0034394 GO:0006468 GO:0031667 GO:0007165 GO:0061053 GO:0060675 GO:0060412
InterPro	IPR005817 IPR026536 IPR018161
PANTHER	PTHR12027 PTHR12027:SF7
Pfam	PF00110
PRINTS	PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003281	ventricular septum development	PMID:22569553^[1]	ECO:0000316		UniProtKB:P22725	P		Figure 2 A and D: they show both the wild type and the double mutant Wnt5a -/-;Wnt11-/-. It can also be seen in figure 2 B and C that the single mutants do not fully develop the ventricular septum	complete CACAO 11159
	GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	PMID:22569553^[1]	ECO:0000316		UniProtKB:P22725	P		Figure 5 shows that Wnt5a and Wnt11 are both required to negatively regulate the canonical Wnt signaling pathway. In 5 A&B it shows that the double mutant Wnt5a-/-; Wnt11-/- shows more stained cells than the wild type controls when crossed with BAT-GAL strain Wnt reporter line and stained with X-gal. C-F shows increased expression of genes (in double mutants Wnt5a-/-;Wnt11-/-) which are upregulated by Beta-catenin signaling in the canonical wnt pathway. Figures 2&3 both show Wnt11 and Wnt5a's function as positive regulators of heart induction.	complete CACAO 11191
	GO:0003283	atrial septum development	PMID:22569553^[1]	ECO:0000316		UniProtKB:P22725	P		Figure 2 A and D Hematoxylin and Eosin (H+E) staining of histological sections at E9.5 of the wild type and the double mutant Wnt5a -/-;Wnt11-/- are shown. It can be seen in the double mutant only single chamber hearts are formed from the double mutant. There is no atrial septum development in the double mutant.	complete CACAO 11192
	GO:0003138	primary heart field specification	PMID:22569553^[1]	ECO:0000316		UniProtKB:P22725	P		Figure 4 E&H show the effect of recombinant Wnt5a and/or WNT11 proteins on gene expression in EBs. The expression of Mesp1 which is "expressed in early precardiac mesoderm and the cardiac crescent but later extinguished as the heart tube develops" and Nkx2.5 which "which marks both FHF and SHF cardiac progenitors" were both increased most when treated with both Wnt5a and Wnt11.	complete CACAO 11193
	GO:0003139	secondary heart field specification	PMID:22569553^[1]	ECO:0000316		UniProtKB:P22725	P		Figure 3 A-D,I and Figure 4 F,G,H. Figure 3: "sections of E9.5 double-mutant, single-mutant and wild-type embryos were stained for Isl1 protein expression". "Isl1+ cells in Wnt5a–/–; Wnt11–/– embryos stained much less intensely than those in wild-type and single-mutant controls". Figure 4 F shows that when treated with Wnt5a and Wnt11, there is an increase in expression of Tbx5, Isl1, and Nkx2.5. Tbx5 is "expressed in the precardiac mesoderm and cardiac crescent before being restricted to the venous pole of the heart" and Isl1 and Nkx2.5 both mark SHF cardiac progenitors.	complete CACAO 11194
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0090037	positive regulation of protein kinase C signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0061101	neuroendocrine cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
enables	GO:0030295	protein kinase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O96014	F		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090272	negative regulation of fibroblast growth factor production	PMID:18191119^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18155657^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090037	positive regulation of protein kinase C signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072201	negative regulation of mesenchymal cell proliferation	PMID:18191119^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	PMID:25959411^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070830	bicellular tight junction assembly	PMID:17767158^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0062009	secondary palate development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061101	neuroendocrine cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061053	somite development	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060775	planar cell polarity pathway involved in gastrula mediolateral intercalation	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P	occurs_in:(EMAPA:16191)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060412	ventricular septum morphogenesis	PMID:17767158^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:19213727^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060028	convergent extension involved in axis elongation	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P	occurs_in:(EMAPA:16183)\|occurs_in:(EMAPA:16191)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:18191119^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048844	artery morphogenesis	PMID:17767158^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048570	notochord morphogenesis	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P	results_in_morphogenesis_of:(EMAPA:16191)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048341	paraxial mesoderm formation	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045199	maintenance of epithelial cell apical/basal polarity	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P	occurs_in:(EMAPA:16191) occurs_in:(CL:0007007)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043547	positive regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:18191119^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17930) regulates_o_occurs_in:(CL:0000066)\|occurs_in(EMAPA:17930) regulates_o_occurs_in:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035567	non-canonical Wnt signaling pathway	PMID:17767158^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034394	protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032915	positive regulation of transforming growth factor beta2 production	PMID:17767158^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665014	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:8700530^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
enables	GO:0030295	protein kinase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:19213727^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88177	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:18155657^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O96014	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003402	planar cell polarity pathway involved in axis elongation	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P	occurs_in:(EMAPA:16191)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	PMID:17767158^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2665014	P	has_participant:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	PMID:25813538^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:21281623^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:19213727^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88177	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:19213727^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1922667 MGI:MGI:88177	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030295	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030295	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030295	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V819 ensembl:ENSRNOP00000021674	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V819 ensembl:ENSRNOP00000021674	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0090037	positive regulation of protein kinase C signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0072177	mesonephric duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0061101	neuroendocrine cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0060675	ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0060484	lung-associated mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0060197	cloacal septation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	F		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
enables	GO:0030295	protein kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O96014 ensembl:ENSP00000325526	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:9889131^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:9889131^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	PMID:9889131^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9889131^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Cohen, ED et al. (2012) Wnt5a and Wnt11 are essential for second heart field progenitor development. Development 139 1931-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Lee, JM et al. (2008) Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development. Dev. Biol. 314 341-50 PubMed GONUTS page
↑ ^4.0 ^4.1 Ouji, Y et al. (2008) Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem. Biophys. Res. Commun. 367 299-304 PubMed GONUTS page
↑ Li, J et al. (2015) MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11. Bone 78 130-41 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Zhou, W et al. (2007) Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat. Genet. 39 1225-34 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Andre, P et al. (2015) Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development 142 1516-27 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Friedman, MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J. Biol. Chem. 284 14117-25 PubMed GONUTS page
↑ Christiansen, JH et al. (1996) Murine WNT11 is a secreted glycoprotein that morphologically transforms mammary epithelial cells. Oncogene 12 2705-11 PubMed GONUTS page
↑ Nie, X et al. (2011) Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev. Biol. 352 141-51 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page

[PMID:22569553-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Cohen, ED et al. (2012) Wnt5a and Wnt11 are essential for second heart field progenitor development. Development 139 1931-40 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18191119-3] 3.0 ^3.1 ^3.2 ^3.3 Lee, JM et al. (2008) Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development. Dev. Biol. 314 341-50 PubMed GONUTS page

[PMID:18155657-4] 4.0 ^4.1 Ouji, Y et al. (2008) Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem. Biophys. Res. Commun. 367 299-304 PubMed GONUTS page

[PMID:25959411-5] Li, J et al. (2015) MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11. Bone 78 130-41 PubMed GONUTS page

[PMID:17767158-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Zhou, W et al. (2007) Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat. Genet. 39 1225-34 PubMed GONUTS page

[PMID:25813538-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Andre, P et al. (2015) Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development 142 1516-27 PubMed GONUTS page

[PMID:19213727-8] 8.0 ^8.1 ^8.2 ^8.3 Friedman, MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J. Biol. Chem. 284 14117-25 PubMed GONUTS page

[PMID:8700530-9] Christiansen, JH et al. (1996) Murine WNT11 is a secreted glycoprotein that morphologically transforms mammary epithelial cells. Oncogene 12 2705-11 PubMed GONUTS page

[PMID:21281623-10] Nie, X et al. (2011) Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev. Biol. 352 141-51 PubMed GONUTS page

[PMID:9889131-11] 11.0 ^11.1 ^11.2 ^11.3 Loureiro, JJ (1999) The Wnts. Curr. Biol. 9 R4 PubMed GONUTS page

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MOUSE:WNT11

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