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PMID:18191119

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Citation

Lee, JM, Kim, JY, Cho, KW, Lee, MJ, Cho, SW, Kwak, S, Cai, J and Jung, HS (2008) Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development. Dev. Biol. 314:341-50

Abstract

Various cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis.

Links

PubMed Online version:10.1016/j.ydbio.2007.11.033

Keywords

Aging/physiology; Animals; Electroporation; Immunohistochemistry; In Situ Hybridization; Maxilla/cytology; Maxilla/growth & development; Mice; Mice, Inbred ICR; Organ Culture Techniques; Palate/cytology; Palate/growth & development; Polymerase Chain Reaction; RNA, Small Interfering/genetics; Receptor Cross-Talk/physiology; Receptor, Fibroblast Growth Factor, Type 1/genetics; Receptor, Fibroblast Growth Factor, Type 1/physiology; Wnt Proteins/genetics; Wnt Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FGFR1

acts_upstream_of_or_within

GO:0002053: positive regulation of mesenchymal cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FGFR1

acts_upstream_of_or_within

GO:0010629: negative regulation of gene expression

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FGFR1

acts_upstream_of_or_within

GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(CL:0000134)
  • regulates_o_occurs_in:(EMAPA:17930)

Seeded From UniProt

complete

MOUSE:WNT11

acts_upstream_of_or_within

GO:0043065: positive regulation of apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:17930)
  • regulates_o_occurs_in:(CL:0000066)|occurs_in(EMAPA:17930)
  • regulates_o_occurs_in:(CL:0000134)

Seeded From UniProt

complete

MOUSE:WNT11

acts_upstream_of_or_within

GO:0060021: roof of mouth development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:WNT11

acts_upstream_of_or_within

GO:0072201: negative regulation of mesenchymal cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:WNT11

acts_upstream_of_or_within

GO:0090272: negative regulation of fibroblast growth factor production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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