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HUMAN:IL33
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IL33 (synonyms: C9orf26, IL1F11, NFHEV) | |
| Protein Name(s) | Interleukin-33
IL-33 Interleukin-1 family member 11 IL-1F11 Nuclear factor from high endothelial venules NF-HEV Interleukin-33 (95-270) Interleukin-33 (99-270) Interleukin-33 (109-270) | |
| External Links | ||
| UniProt | O95760 | |
| EMBL | AB024518 AY905581 HQ641439 AK295908 AK303943 AK313414 CR407619 AL353741 CH471071 CH471071 CH471071 BC047085 | |
| CCDS | CCDS56563.1 CCDS56564.1 CCDS6468.1 | |
| RefSeq | NP_001186569.1 NP_001186570.1 NP_001300973.1 NP_001300974.1 NP_001300975.1 NP_001300976.1 NP_001300977.1 NP_254274.1 | |
| UniGene | Hs.731660 | |
| PDB | 2KLL 4KC3 | |
| PDBsum | 2KLL 4KC3 | |
| ProteinModelPortal | O95760 | |
| SMR | O95760 | |
| BioGrid | 124776 | |
| DIP | DIP-37862N | |
| IntAct | O95760 | |
| MINT | MINT-1423224 | |
| STRING | 9606.ENSP00000370842 | |
| iPTMnet | O95760 | |
| PhosphoSite | O95760 | |
| BioMuta | IL33 | |
| PaxDb | O95760 | |
| PRIDE | O95760 | |
| Ensembl | ENST00000381434 ENST00000417746 ENST00000456383 ENST00000611532 | |
| GeneID | 90865 | |
| KEGG | hsa:90865 | |
| UCSC | uc011lmh.3 | |
| CTD | 90865 | |
| GeneCards | IL33 | |
| HGNC | HGNC:16028 | |
| HPA | CAB007057 HPA024426 | |
| MIM | 608678 | |
| neXtProt | NX_O95760 | |
| PharmGKB | PA162392005 | |
| eggNOG | ENOG410J11H ENOG41118MB | |
| GeneTree | ENSGT00390000005185 | |
| HOGENOM | HOG000070215 | |
| HOVERGEN | HBG081791 | |
| InParanoid | O95760 | |
| KO | K12967 | |
| OMA | SPTKDFW | |
| OrthoDB | EOG7TQV1R | |
| PhylomeDB | O95760 | |
| TreeFam | TF338120 | |
| EvolutionaryTrace | O95760 | |
| GenomeRNAi | 90865 | |
| NextBio | 35467794 | |
| PRO | PR:O95760 | |
| Proteomes | UP000005640 | |
| Bgee | O95760 | |
| CleanEx | HS_IL33 | |
| Genevisible | O95760 | |
| GO | GO:0005694 GO:0005615 GO:0005634 GO:0030133 GO:0005125 GO:0051607 GO:0097191 GO:0051025 GO:0032689 GO:0002686 GO:0002826 GO:0090197 GO:0051024 GO:0050729 GO:0032736 GO:0032753 GO:0032754 GO:0032755 GO:0043032 GO:0032436 GO:0045944 GO:0002830 GO:0006351 | |
| InterPro | IPR026145 | |
| PANTHER | PTHR21114 | |
| Pfam | PF15095 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1,3,4 show accumulation of IL 33 in the nuclei of various normal human tissue. |
complete | |||||
| GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
C |
Figure 2(A,D,G) and the magnifications (C,F,I) Show the association of IL33 in the nuclei of human tissue after staining with three different IL33 antisera |
complete | |||||
| GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
P |
Figure 5 (A,B) show decrease in transcription |
complete | |||||
| GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
C |
Figure 2 (C,F,I) shows the association of IL33 expression with heterochromatin |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 3A,B shows localizations of IL33 in the nuclei of epithelial cells. |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1A shows IL33 in the nucleus |
complete | |||||
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 1A shows localization of IL33 in the cytoplasm |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 1 shows expression of Il33 in the nuclei of Normal human tissue. Figure 2F shows expression of Il33 in the nucleus of superconfluent cells |
complete | |||||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
ECO:0000315 |
P |
Figure 5 (A,B) show decrease in transcription |
complete | |||||
|
involved_in |
GO:0090197 |
positive regulation of chemokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043032 |
positive regulation of macrophage activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1924375 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1924375 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090197 |
positive regulation of chemokine secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061518 |
microglial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051025 |
negative regulation of immunoglobulin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051024 |
positive regulation of immunoglobulin secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043032 |
positive regulation of macrophage activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032754 |
positive regulation of interleukin-5 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032753 |
positive regulation of interleukin-4 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032736 |
positive regulation of interleukin-13 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032689 |
negative regulation of interferon-gamma production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002830 |
positive regulation of type 2 immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002826 |
negative regulation of T-helper 1 type immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002686 |
negative regulation of leukocyte migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002282 |
microglial cell activation involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002281 |
macrophage activation involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BVZ5 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0150078 |
positive regulation of neuroinflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038172 |
interleukin-33-mediated signaling pathway |
Reactome:R-HSA-9014843 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016579 |
protein deubiquitination |
Reactome:R-HSA-5688426 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6783177 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-448629 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030133 |
transport vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Moussion, C et al. (2008) The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS ONE 3 e3331 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Carriere, V et al. (2007) IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc. Natl. Acad. Sci. U.S.A. 104 282-7 PubMed GONUTS page
- ↑ Kouzaki, H et al. (2011) The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J. Immunol. 186 4375-87 PubMed GONUTS page
- ↑ 4.0 4.1 Kakkar, R et al. (2012) Interleukin 33 as a mechanically responsive cytokine secreted by living cells. J. Biol. Chem. 287 6941-8 PubMed GONUTS page
- ↑ Küchler, AM et al. (2008) Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation. Am. J. Pathol. 173 1229-42 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Kurowska-Stolarska, M et al. (2009) IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J. Immunol. 183 6469-77 PubMed GONUTS page
- ↑ 7.0 7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Gu, Y et al. () Role of TNF in mast cell neuroinflammation and pain. J. Biol. Regul. Homeost. Agents 29 787-91 PubMed GONUTS page
c
e
m
n
- GO:0002826 ! negative regulation of T-helper 1 type immune response
- GO:0032689 ! negative regulation of type II interferon production
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0051025 ! negative regulation of immunoglobulin secretion
- GO:0002686 ! negative regulation of leukocyte migration
- GO:0005720 ! nuclear heterochromatin
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
p
- GO:0032736 ! positive regulation of interleukin-13 production
- GO:0032753 ! positive regulation of interleukin-4 production
- GO:0002830 ! positive regulation of type 2 immune response
- GO:0150078 ! positive regulation of neuroinflammatory response
- GO:0090197 ! positive regulation of chemokine secretion
- GO:0050729 ! positive regulation of inflammatory response
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0043032 ! positive regulation of macrophage activation
- GO:0032755 ! positive regulation of interleukin-6 production
- GO:0010628 ! positive regulation of gene expression
- GO:0051024 ! positive regulation of immunoglobulin secretion
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0032754 ! positive regulation of interleukin-5 production
- Primates
- GO:0016579 ! protein deubiquitination
