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PMID:18836528

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Citation

Moussion, C, Ortega, N and Girard, JP (2008) The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS ONE 3:e3331

Abstract

Interleukin-33 (IL-33) is an IL-1-like cytokine ligand for the IL-1 receptor-related protein ST2, that activates mast cells and Th2 lymphocytes, and induces production of Th2-associated cytokines in vivo. We initially discovered IL-33 as a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs, that associates with chromatin and exhibits transcriptional regulatory properties. This suggested that, similarly to IL-1alpha and chromatin-associated cytokine HMGB1, IL-33 may act as both a cytokine and a nuclear factor. Although the activity of recombinant IL-33 has been well characterized, little is known yet about the expression pattern of endogenous IL-33 in vivo.

Links

PubMed PMC2556082 Online version:10.1371/journal.pone.0003331

Keywords

Actins/metabolism; Cell Nucleus/metabolism; Cytokines/genetics; Cytokines/metabolism; Desmin/metabolism; Endothelial Cells/metabolism; Epithelial Cells/metabolism; Fluorescent Dyes/metabolism; Humans; Immunohistochemistry; Indoles/metabolism; Inflammation Mediators/metabolism; Interleukin-1/genetics; Interleukin-1/metabolism; Interleukin-33; Interleukins/genetics; Interleukins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:IL33

GO:0005634: nucleus

ECO:0000314:

C

Figure 1,3,4 show accumulation of IL 33 in the nuclei of various normal human tissue.

complete
CACAO 11775

Notes

See also

References

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