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CHICK:IFNG

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) IFNG
Protein Name(s) Interferon gamma

IFN-gamma

External Links
UniProt P49708
EMBL U27465
X99774
Y07922
U96875
U96872
U96873
U96874
AF424744
AY501004
FJ788637
PIR JC6536
RefSeq NP_990480.1
UniGene Gga.916
ProteinModelPortal P49708
STRING 9031.ENSGALP00000016086
PaxDb P49708
Ensembl ENSGALT00000016105
GeneID 396054
KEGG gga:396054
CTD 3458
eggNOG NOG45353
GeneTree ENSGT00390000007831
HOGENOM HOG000254784
HOVERGEN HBG056912
InParanoid P49708
KO K04687
OMA KEYFNAS
OrthoDB EOG7VHSZM
PhylomeDB P49708
TreeFam TF336308
Reactome REACT_298551
REACT_340124
NextBio 20816114
PRO PR:P49708
Proteomes UP000000539
GO GO:0009897
GO:0005615
GO:0005622
GO:0005125
GO:0002250
GO:0019882
GO:0002302
GO:0007050
GO:0071351
GO:0071222
GO:0042742
GO:0042832
GO:0051607
GO:0030968
GO:0097191
GO:0006959
GO:0042116
GO:0045918
GO:0044130
GO:0032700
GO:0031642
GO:0048662
GO:0001781
GO:0030593
GO:0060559
GO:0045080
GO:0010634
GO:0060550
GO:0060552
GO:0050718
GO:0045084
GO:0032747
GO:0045410
GO:0048304
GO:0051712
GO:0051044
GO:0045348
GO:0045429
GO:0045672
GO:0033141
GO:2000379
GO:0034393
GO:0042102
GO:0045944
GO:2000309
GO:0032760
GO:0042511
GO:0000060
GO:0050796
GO:0070673
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR002069
PANTHER PTHR11419
Pfam PF00714
PIRSF PIRSF001936
ProDom PD002435
SUPFAM SSF47266

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01579

P

Seeded From UniProt

complete

involved_in

GO:0070673

response to interleukin-18

PMID:12902481[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000492)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:12902481[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042116

macrophage activation

PMID:25086294[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

PMID:18593329[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:18593329[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045918

negative regulation of cytolysis

PMID:18593329[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107656
PANTHER:PTN000892718

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107656
PANTHER:PTN000892718
RGD:2866
UniProtKB:P07353
UniProtKB:P49708

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107656
PANTHER:PTN000892718

F

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107656
PANTHER:PTN000892718

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:2000309

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:1904798

positive regulation of core promoter binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0090312

positive regulation of protein deacetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0071902

positive regulation of protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0060557

positive regulation of vitamin D biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0060552

positive regulation of fructose 1,6-bisphosphate metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0060550

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0051712

positive regulation of killing of cells of other organism

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0050796

regulation of insulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0048662

negative regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0045672

positive regulation of osteoclast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0045429

positive regulation of nitric oxide biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0042307

positive regulation of protein import into nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0034393

positive regulation of smooth muscle cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0033141

positive regulation of peptidyl-serine phosphorylation of STAT protein

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0032834

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0032747

positive regulation of interleukin-23 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0032735

positive regulation of interleukin-12 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0032700

negative regulation of interleukin-17 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0031334

positive regulation of protein complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0010835

regulation of protein ADP-ribosylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0010634

positive regulation of epithelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

C

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01579
ensembl:ENSP00000229135

P

Seeded From UniProt

complete

enables

GO:0005133

interferon-gamma receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002069

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002069

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002069

P

Seeded From UniProt

complete

involved_in

GO:0001959

regulation of cytokine-mediated signaling pathway

PMID:19247647[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0040008

regulation of growth

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0341

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Göbel, TW et al. (2003) IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species. J. Immunol. 171 1809-15 PubMed GONUTS page
  2. Kim, S et al. (2014) Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor. Dev. Comp. Immunol. 47 319-26 PubMed GONUTS page
  3. 3.0 3.1 3.2 Karpala, AJ et al. (2008) Molecular cloning, expression, and characterization of chicken IFN -lambda. J. Interferon Cytokine Res. 28 341-50 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. Downing, T et al. (2009) Contrasting evolution of diversity at two disease-associated chicken genes. Immunogenetics 61 303-14 PubMed GONUTS page