HUMAN:CIB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CIB1 (synonyms: CIB, KIP, PRKDCIP)
Protein Name(s)	Calcium and integrin-binding protein 1 CIB Calcium- and integrin-binding protein CIBP Calmyrin DNA-PKcs-interacting protein Kinase-interacting protein KIP SNK-interacting protein 2-28 SIP2-28
External Links
UniProt	Q99828
EMBL	U82226 U85611 AB021866 JQ246073 U83236 CR456955 AB451276 AB451406 CH471101 BC000846
CCDS	CCDS10360.1 CCDS73781.1
RefSeq	NP_001264693.1 NP_006375.2
UniGene	Hs.715556
PDB	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
PDBsum	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
ProteinModelPortal	Q99828
SMR	Q99828
BioGrid	115774
DIP	DIP-31260N
IntAct	Q99828
MINT	MINT-95290
STRING	9606.ENSP00000333873
PhosphoSite	Q99828
DMDM	134047806
MaxQB	Q99828
PaxDb	Q99828
PRIDE	Q99828
DNASU	10519
Ensembl	ENST00000328649 ENST00000612800
GeneID	10519
KEGG	hsa:10519
UCSC	uc002bpb.4
CTD	10519
GeneCards	GC15M090773
H-InvDB	HIX0012576
HGNC	HGNC:16920
HPA	CAB012991 HPA048825
MIM	602293
neXtProt	NX_Q99828
PharmGKB	PA38423
eggNOG	NOG257993
GeneTree	ENSGT00760000119179
HOVERGEN	HBG107344
InParanoid	Q99828
KO	K17259
OMA	YKRFSEL
OrthoDB	EOG7KM5V7
PhylomeDB	Q99828
TreeFam	TF313865
ChiTaRS	CIB1
EvolutionaryTrace	Q99828
GeneWiki	CIB1
GenomeRNAi	10519
NextBio	35528000
PRO	PR:Q99828
Proteomes	UP000005640
Bgee	Q99828
CleanEx	HS_CIB1
Genevestigator	Q99828
GO	GO:0016324 GO:0071944 GO:0005813 GO:0005737 GO:0005783 GO:0070062 GO:0032433 GO:0005794 GO:0030426 GO:0030027 GO:0016020 GO:0043005 GO:0043025 GO:0005654 GO:0005634 GO:0048471 GO:0005886 GO:0032587 GO:0042383 GO:0031982 GO:0005509 GO:0043495 GO:0017016 GO:0001525 GO:0006915 GO:0007155 GO:0051301 GO:0006974 GO:0071363 GO:1990090 GO:0071356 GO:0031122 GO:0006302 GO:0007113 GO:0097191 GO:0043066 GO:0008285 GO:0045653 GO:0007026 GO:0010977 GO:0051898 GO:0001933 GO:0030220 GO:0070886 GO:0033630 GO:0030307 GO:0030335 GO:0090050 GO:0008284 GO:0001954 GO:0070374 GO:0090004 GO:1901313 GO:2000256 GO:0048554 GO:0051092 GO:0001934 GO:0071902 GO:0090314 GO:1900026 GO:0051302 GO:0042127 GO:0002931 GO:0007286 GO:0038163
Gene3D	1.10.238.10
InterPro	IPR011992 IPR018247 IPR002048
Pfam	PF13499
SMART	SM00054
PROSITE	PS00018 PS50222

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050685	positive regulation of mRNA processing	PMID:20473878^[1]	ECO:0000314			P		Figure 1A-C presents results suggesting that CIB1 mRNA expression is upregulated in breast cancer tissue.	complete CACAO 9256
	GO:0008427	calcium-dependent protein kinase inhibitor activity	PMID:20473878^[1]	ECO:0000314			F		Figure 5 shows CIB1 inhibits Plk3 kinase activity.	complete CACAO 9261
	GO:0008427	calcium-dependent protein kinase inhibitor activity	PMID:20473878^[1]	ECO:0000315			F		Figure 5	complete CACAO 9262
	GO:0005515	protein binding	PMID:20473878^[1]	ECO:0000314			F		Figure 4A-C proves that the interaction of CIB1 and Plk3 to bind to each other is independent of the presence or absence of intracellular calcium.	complete CACAO 9264
	GO:0051592	response to calcium ion	PMID:20473878^[1]	ECO:0000314			P		Figure 5A-C shows that calcium-bound CIB1 inhibits Plk3 kinase activity and an absence of calcium to bind to CIB1 prevents CIB1 from inhibiting Plk3 kinase activity.	complete CACAO 9266
	GO:0005515	protein binding	PMID:20473878^[1]	ECO:0000314			F		Figure 6A-D presents results suggesting that CIB1 is a regulatory subunit of Plk3.	complete CACAO 9268
	GO:0005886	plasma membrane	PMID:20473878^[1]	ECO:0000314			C		In figure 2Aii, CIB1 is seen localized along the cell membrane indicating plasma membrane localization as visualized in H & E stains.	complete CACAO 9347
	GO:0030291	protein serine/threonine kinase inhibitor activity	PMID:20473878^[1]	ECO:0000314			F		Fig 5	complete CACAO 9350
	GO:0005515	protein binding	PMID:20473878^[1]	ECO:0000314			F		Figure 3A-D shows that CIB1 and Plk3 interact to bind to each other with a high affinity in the cancer cell line T47D.	complete
enables	GO:0008427	calcium-dependent protein kinase inhibitor activity	PMID:20473878^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030291	protein serine/threonine kinase inhibitor activity	PMID:20473878^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20473878^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:19190083^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002202)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:20639889^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	PMID:20639889^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0003300) occurs_at:(GO:0042383)	Seeded From UniProt	complete
enables	GO:0043495	protein membrane anchor	PMID:20639889^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Z0F4	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:20639889^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20639889^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:10366599^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:12011095^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10366599^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:10366599^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10366599^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:10366599^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:15475008^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000256	positive regulation of male germ cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	PMID:11756406^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	PMID:19854831^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:11756406^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:20951827^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:19854831^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0051302	regulation of cell division	PMID:20951827^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:19854831^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11756406^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045653	negative regulation of megakaryocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:19854831^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:20951827^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038163	thrombopoietin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:11756406^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	PMID:20951827^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031122	cytoplasmic microtubule organization	PMID:20951827^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017016	Ras GTPase binding	PMID:11756406^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60763	F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:21264284^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0007286	spermatid development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0007113	endomitotic cell cycle	PMID:21264284^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19854831^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:20951827^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11756406^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21215777^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19854831^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11756406^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0F4	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008427	P		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030291	P		Seeded From UniProt	complete
involved_in	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R010 ensembl:ENSRNOP00000047025	C		Seeded From UniProt	complete
involved_in	GO:2000256	positive regulation of male germ cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0045653	negative regulation of megakaryocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	F		Seeded From UniProt	complete
enables	GO:0043495	protein membrane anchor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	F		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	C		Seeded From UniProt	complete
involved_in	GO:0038163	thrombopoietin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0007286	spermatid development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	C		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0F4 ensembl:ENSMUSP00000070901	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:9030514^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:9372844^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	PMID:19805025^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0744	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0470	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0301	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Naik, MU et al. (2011) Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells. Int. J. Cancer 128 587-96 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Heineke, J et al. (2010) CIB1 is a regulator of pathological cardiac hypertrophy. Nat. Med. 16 872-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Stabler, SM et al. (1999) A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein. J. Cell Biol. 145 1277-92 PubMed GONUTS page
↑ Henderson, MJ et al. (2002) EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J. Biol. Chem. 277 26468-78 PubMed GONUTS page
↑ Zhu, J et al. (2004) Calcium binding sequences in calmyrin regulates interaction with presenilin-2. Exp. Cell Res. 300 440-54 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Sobczak, A et al. (2011) Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. Biochim. Biophys. Acta 1813 1025-37 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Haataja, L et al. (2002) The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. J. Biol. Chem. 277 8321-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Jarman, KE et al. (2010) Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. J. Biol. Chem. 285 483-92 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Naik, MU & Naik, UP (2011) Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. Int. J. Biochem. Cell Biol. 43 120-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Kostyak, JC & Naik, UP (2011) Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells. PLoS ONE 6 e14513 PubMed GONUTS page
↑ Naik, UP et al. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J. Biol. Chem. 272 4651-4 PubMed GONUTS page
↑ Wu, X & Lieber, MR (1997) Interaction between DNA-dependent protein kinase and a novel protein, KIP. Mutat. Res. 385 13-20 PubMed GONUTS page
↑ Yoon, KW et al. (2009) CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 17389-94 PubMed GONUTS page

[PMID:20473878-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Naik, MU et al. (2011) Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells. Int. J. Cancer 128 587-96 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19190083-3] Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-5] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:20639889-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Heineke, J et al. (2010) CIB1 is a regulator of pathological cardiac hypertrophy. Nat. Med. 16 872-9 PubMed GONUTS page

[PMID:10366599-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Stabler, SM et al. (1999) A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein. J. Cell Biol. 145 1277-92 PubMed GONUTS page

[PMID:12011095-8] Henderson, MJ et al. (2002) EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J. Biol. Chem. 277 26468-78 PubMed GONUTS page

[PMID:15475008-9] Zhu, J et al. (2004) Calcium binding sequences in calmyrin regulates interaction with presenilin-2. Exp. Cell Res. 300 440-54 PubMed GONUTS page

[PMID:21215777-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Sobczak, A et al. (2011) Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. Biochim. Biophys. Acta 1813 1025-37 PubMed GONUTS page

[PMID:11756406-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Haataja, L et al. (2002) The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. J. Biol. Chem. 277 8321-8 PubMed GONUTS page

[PMID:19854831-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Jarman, KE et al. (2010) Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. J. Biol. Chem. 285 483-92 PubMed GONUTS page

[PMID:20951827-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Naik, MU & Naik, UP (2011) Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. Int. J. Biochem. Cell Biol. 43 120-9 PubMed GONUTS page

[PMID:21264284-14] 14.0 ^14.1 Kostyak, JC & Naik, UP (2011) Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells. PLoS ONE 6 e14513 PubMed GONUTS page

[PMID:9030514-15] Naik, UP et al. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J. Biol. Chem. 272 4651-4 PubMed GONUTS page

[PMID:9372844-16] Wu, X & Lieber, MR (1997) Interaction between DNA-dependent protein kinase and a novel protein, KIP. Mutat. Res. 385 13-20 PubMed GONUTS page

[PMID:19805025-17] Yoon, KW et al. (2009) CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 17389-94 PubMed GONUTS page

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HUMAN:CIB1

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