MOUSE:TNR6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fas (synonyms: Apt1, Tnfrsf6)
Protein Name(s)	Tumor necrosis factor receptor superfamily member 6 Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor
External Links
UniProt	P25446
EMBL	M83649 AK002590 AJ295702 AJ295703 AJ295704 DQ846748 CH466534 BC061160 S56490 S56485 S56486
CCDS	CCDS29758.1
PIR	A46484
RefSeq	NP_032013.2
UniGene	Mm.1626
PDB	3OQ9
PDBsum	3OQ9
ProteinModelPortal	P25446
SMR	P25446
BioGrid	199594
DIP	DIP-31093N
IntAct	P25446
MINT	MINT-144559
PhosphoSite	P25446
MaxQB	P25446
PaxDb	P25446
PRIDE	P25446
Ensembl	ENSMUST00000025691
GeneID	14102
KEGG	mmu:14102
UCSC	uc008hgi.2
CTD	355
MGI	MGI:95484
eggNOG	NOG45364
GeneTree	ENSGT00730000111280
HOGENOM	HOG000139681
HOVERGEN	HBG004091
InParanoid	P25446
KO	K04390
OMA	CDPCTKC
OrthoDB	EOG7DVDC8
TreeFam	TF333916
Reactome	REACT_215122 REACT_241657 REACT_243608 REACT_263715
EvolutionaryTrace	P25446
NextBio	285130
PRO	PR:P25446
Proteomes	UP000000589
Bgee	P25446
CleanEx	MM_FAS
ExpressionAtlas	P25446
Genevestigator	P25446
GO	GO:0031265 GO:0009986 GO:0005737 GO:0009897 GO:0005576 GO:0070062 GO:0016021 GO:0045121 GO:0005634 GO:0004888 GO:0006924 GO:0006915 GO:0097190 GO:0019724 GO:0071455 GO:0071285 GO:0071260 GO:0007623 GO:0097191 GO:0097192 GO:0008625 GO:0010467 GO:0097284 GO:0002377 GO:0006925 GO:0097049 GO:0097527 GO:0043066 GO:0050869 GO:0045060 GO:0051402 GO:2001241 GO:0032464 GO:0090200 GO:0051260 GO:0045619 GO:0045637 GO:0003014 GO:0051384 GO:0009636 GO:0048536 GO:0043029 GO:0006927
Gene3D	1.10.533.10
InterPro	IPR011029 IPR000488 IPR008063 IPR001368
Pfam	PF00531 PF00020
PRINTS	PR01680
SMART	SM00005 SM00208
SUPFAM	SSF47986
PROSITE	PS50017 PS00652 PS50050

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:9555665^[1]	ECO:0000314			P		figure 5: increased intensity of fas mRNA detected in northern blot of ischemic kidney figure 6 & 7: fas mRNA detected in apoptotic epethelial cells	complete CACAO 6752
enables	GO:0005516	calmodulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25445	F		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:10950869^[2]	ECO:0000305	curator inference used in manual assertion	GO:0032464	P		Seeded From UniProt	complete
involved_in	GO:0032464	positive regulation of protein homooligomerization	PMID:10950869^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:10950869^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031265	CD95 death-inducing signaling complex	PMID:20935634^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:23785138^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900148	negative regulation of Schwann cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	PMID:21052097^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108212	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097284	hepatocyte apoptotic process	PMID:20436477^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108093 MGI:MGI:1929260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:13679421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:13679421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:12011074^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:17980593^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846) occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:8666928^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000790)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:7511063^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097049	motor neuron apoptotic process	PMID:13679421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861923	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097049	motor neuron apoptotic process	PMID:13679421^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071455	cellular response to hyperoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071285	cellular response to lithium ion	PMID:20530871^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	occurs_in:(EMAPA:16894) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070227	lymphocyte apoptotic process	PMID:15632112^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:20530871^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	occurs_in:(EMAPA:16894) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051384	response to glucocorticoid	PMID:8640868^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051384	response to glucocorticoid	PMID:7602121^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334 MGI:MGI:1856384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	PMID:8524870^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050869	negative regulation of B cell activation	PMID:6610701^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	regulates_o_has_participant:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048536	spleen development	PMID:18199416^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	results_in_development_of:(EMAPA:18767)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045637	regulation of myeloid cell differentiation	PMID:9697835^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	occurs_in:(EMAPA:32760) regulates_o_results_in_acquisition_of_features_of:(CL:0000049)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045619	regulation of lymphocyte differentiation	PMID:6610701^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000084)\|regulates_o_results_in_acquisition_of_features_of:(CL:0000236)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045060	negative thymic T cell selection	PMID:10429671^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:7595210^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043029	T cell homeostasis	PMID:8640868^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856384	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036337	Fas signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034198	cellular response to amino acid starvation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032872	regulation of stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
part_of	GO:0031265	CD95 death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	C		Seeded From UniProt	complete
part_of	GO:0031265	CD95 death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	C		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031104	dendrite regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019724	B cell mediated immunity	PMID:18199416^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010626	negative regulation of Schwann cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010467	gene expression	PMID:7602121^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334 MGI:MGI:1856384	P	occurs_in:(CL:0000084) has_participant:(MGI:MGI:88138)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:7595210^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15632112^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8788039^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)\|part_of:(CL:0000236)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:23583643^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000236)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16493007^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000542)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16365167^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:15632112^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:12801066^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000451)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009636	response to toxic substance	PMID:8557033^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:12431371^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096330	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:8524870^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:12801066^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:12431371^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:10429671^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:8524870^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:18363966^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:15632112^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:15039234^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32760) regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:12801066^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:10588860^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006925	inflammatory cell apoptotic process	PMID:12801066^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006925	inflammatory cell apoptotic process	PMID:12801066^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006924	activation-induced cell death of T cells	PMID:8640868^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006924	activation-induced cell death of T cells	PMID:7602121^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334 MGI:MGI:1856384	P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006924	activation-induced cell death of T cells	PMID:12702495^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:8700551^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	occurs_in:(EMAPA:19287)\|occurs_in:(EMAPA:19290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:7595210^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	F		Seeded From UniProt	complete
enables	GO:0005031	tumor necrosis factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002377	immunoglobulin production	PMID:18199416^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856334	P	has_agent:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619831	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P25445	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005031	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008063	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008063	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008063	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000488 InterPro:IPR008063	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008063	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nogae, S et al. (1998) Induction of apoptosis in ischemia-reperfusion model of mouse kidney: possible involvement of Fas. J. Am. Soc. Nephrol. 9 620-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Wei, MC et al. (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14 2060-71 PubMed GONUTS page
↑ Wang, L et al. (2010) The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat. Struct. Mol. Biol. 17 1324-9 PubMed GONUTS page
↑ Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page
↑ Vanlangenakker, N et al. (2011) cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ. 18 656-65 PubMed GONUTS page
↑ Zaltsman, Y et al. (2010) MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat. Cell Biol. 12 553-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Ugolini, G et al. (2003) Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo. J. Neurosci. 23 8526-31 PubMed GONUTS page
↑ Li, S et al. (2002) Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J. Biol. Chem. 277 26912-20 PubMed GONUTS page
↑ Camargo, FD et al. (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 17 2054-60 PubMed GONUTS page
↑ Byth, KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J. Exp. Med. 183 1707-18 PubMed GONUTS page
↑ Takahashi, T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 969-76 PubMed GONUTS page
↑ ^12.0 ^12.1 Gómez-Sintes, R & Lucas, JJ (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J. Clin. Invest. 120 2432-45 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Song, Y & Jacob, CO (2005) The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. J. Biol. Chem. 280 9618-26 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Tamura, A et al. (1996) Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice. Cell. Immunol. 168 220-8 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Tamura, A & Yui, K (1995) Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice. J. Immunol. 155 499-507 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Chu, K et al. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 92 11894-8 PubMed GONUTS page
↑ ^17.0 ^17.1 Davidson, WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J. Immunol. 133 1048-56 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Haraldsson, MK et al. (2008) The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity 28 40-51 PubMed GONUTS page
↑ Traver, D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9 47-57 PubMed GONUTS page
↑ ^20.0 ^20.1 Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Hughes, DP & Crispe, IN (1995) A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J. Exp. Med. 182 1395-401 PubMed GONUTS page
↑ Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page
↑ Vogel, KU et al. (2013) Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 38 655-68 PubMed GONUTS page
↑ Schenten, D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood 107 4849-56 PubMed GONUTS page
↑ Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 Yokota, A et al. (2003) Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol. Immunol. 47 285-93 PubMed GONUTS page
↑ Strasser, A et al. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14 6136-47 PubMed GONUTS page
↑ ^28.0 ^28.1 Datta, SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3 631-43 PubMed GONUTS page
↑ Itoh, S et al. (2008) Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells 13 355-63 PubMed GONUTS page
↑ Hiatt, K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am. J. Pathol. 164 1471-9 PubMed GONUTS page
↑ Estellés, A et al. (1999) The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev. Biol. 216 16-28 PubMed GONUTS page
↑ Boone, DL et al. (2003) Fas is not essential for lamina propria T lymphocyte homeostasis. Am. J. Physiol. Gastrointest. Liver Physiol. 285 G382-8 PubMed GONUTS page
↑ Suzuki, A et al. (1996) Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract. Oncogene 13 31-7 PubMed GONUTS page

[PMID:9555665-1] Nogae, S et al. (1998) Induction of apoptosis in ischemia-reperfusion model of mouse kidney: possible involvement of Fas. J. Am. Soc. Nephrol. 9 620-31 PubMed GONUTS page

[PMID:10950869-2] 2.0 ^2.1 ^2.2 Wei, MC et al. (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14 2060-71 PubMed GONUTS page

[PMID:20935634-3] Wang, L et al. (2010) The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat. Struct. Mol. Biol. 17 1324-9 PubMed GONUTS page

[PMID:23785138-4] Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page

[PMID:21052097-5] Vanlangenakker, N et al. (2011) cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ. 18 656-65 PubMed GONUTS page

[PMID:20436477-6] Zaltsman, Y et al. (2010) MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat. Cell Biol. 12 553-62 PubMed GONUTS page

[PMID:13679421-7] 7.0 ^7.1 ^7.2 ^7.3 Ugolini, G et al. (2003) Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo. J. Neurosci. 23 8526-31 PubMed GONUTS page

[PMID:12011074-8] Li, S et al. (2002) Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J. Biol. Chem. 277 26912-20 PubMed GONUTS page

[PMID:17980593-9] Camargo, FD et al. (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 17 2054-60 PubMed GONUTS page

[PMID:8666928-10] Byth, KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J. Exp. Med. 183 1707-18 PubMed GONUTS page

[PMID:7511063-11] Takahashi, T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 969-76 PubMed GONUTS page

[PMID:20530871-12] 12.0 ^12.1 Gómez-Sintes, R & Lucas, JJ (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J. Clin. Invest. 120 2432-45 PubMed GONUTS page

[PMID:15632112-13] 13.0 ^13.1 ^13.2 ^13.3 Song, Y & Jacob, CO (2005) The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. J. Biol. Chem. 280 9618-26 PubMed GONUTS page

[PMID:8640868-14] 14.0 ^14.1 ^14.2 Tamura, A et al. (1996) Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice. Cell. Immunol. 168 220-8 PubMed GONUTS page

[PMID:7602121-15] 15.0 ^15.1 ^15.2 Tamura, A & Yui, K (1995) Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice. J. Immunol. 155 499-507 PubMed GONUTS page

[PMID:8524870-16] 16.0 ^16.1 ^16.2 Chu, K et al. (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 92 11894-8 PubMed GONUTS page

[PMID:6610701-17] 17.0 ^17.1 Davidson, WF et al. (1984) Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J. Immunol. 133 1048-56 PubMed GONUTS page

[PMID:18199416-18] 18.0 ^18.1 ^18.2 Haraldsson, MK et al. (2008) The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity 28 40-51 PubMed GONUTS page

[PMID:9697835-19] Traver, D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9 47-57 PubMed GONUTS page

[PMID:10429671-20] 20.0 ^20.1 Kishimoto, H & Sprent, J (1999) Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190 65-73 PubMed GONUTS page

[PMID:7595210-21] 21.0 ^21.1 ^21.2 Hughes, DP & Crispe, IN (1995) A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J. Exp. Med. 182 1395-401 PubMed GONUTS page

[PMID:8788039-22] Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page

[PMID:23583643-23] Vogel, KU et al. (2013) Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 38 655-68 PubMed GONUTS page

[PMID:16493007-24] Schenten, D et al. (2006) M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood 107 4849-56 PubMed GONUTS page

[PMID:16365167-25] Piazzolla, D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J. Cell Biol. 171 1013-22 PubMed GONUTS page

[PMID:12801066-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 Yokota, A et al. (2003) Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol. Immunol. 47 285-93 PubMed GONUTS page

[PMID:8557033-27] Strasser, A et al. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14 6136-47 PubMed GONUTS page

[PMID:12431371-28] 28.0 ^28.1 Datta, SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3 631-43 PubMed GONUTS page

[PMID:18363966-29] Itoh, S et al. (2008) Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells 13 355-63 PubMed GONUTS page

[PMID:15039234-30] Hiatt, K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am. J. Pathol. 164 1471-9 PubMed GONUTS page

[PMID:10588860-31] Estellés, A et al. (1999) The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev. Biol. 216 16-28 PubMed GONUTS page

[PMID:12702495-32] Boone, DL et al. (2003) Fas is not essential for lamina propria T lymphocyte homeostasis. Am. J. Physiol. Gastrointest. Liver Physiol. 285 G382-8 PubMed GONUTS page

[PMID:8700551-33] Suzuki, A et al. (1996) Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract. Oncogene 13 31-7 PubMed GONUTS page

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