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PMID:12801066
| Citation |
Yokota, A, Oikawa, A, Matsuda, C, Shinohara, N and Eshima, K (2003) Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol. Immunol. 47:285-93 |
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| Abstract |
In this report, the controversy concerning the sensitivity of dendritic cells (DCs) to Fas-dependent induction of apoptosis was examined using murine DCs. Although DCs could not be lysed when exposed to an anti-Fas antibody, Jo2, the observed resistance turned out to reflect their lack of the expression of Fc(gamma)R necessary for crosslinking the antibody, rather than their intrinsic resistance. Thus, at least a fraction of DCs was sensitive to Jo2 in the presence of Fc(gamma)R-expressing by-standers. Consistently, a significant fraction of DCs was sensitive to Fas-dependent lysis mediated by T cells including the antigen-specific killing by CD4+ T cells. Both immature (class II MHClow) and mature (class II MHChigh) DCs were sensitive to the Fas-based induction of apoptosis. |
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| Keywords |
Animals; Antibodies, Monoclonal/toxicity; Antigens, CD4/metabolism; Antigens, CD95/immunology; Antigens, CD95/metabolism; Antigens, CD95/physiology; Apoptosis; Bone Marrow Cells/cytology; CD4-Positive T-Lymphocytes/immunology; Cells, Cultured; Cytotoxicity, Immunologic; Dendritic Cells/cytology; Dendritic Cells/drug effects; Dendritic Cells/immunology; Drug Resistance; Flow Cytometry/methods; Humans; Interferon-gamma/biosynthesis; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Receptors, IgG/metabolism; Spleen/cytology |
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Significance
Annotations
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