Category:GO:0031264 ! death-inducing signaling complex

name: death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10." [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815]
comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
subset: goslim_pir
synonym: "death receptor-induced signaling complex" EXACT []
synonym: "death receptor-induced signalling complex" EXACT []
synonym: "death-inducing signalling complex" EXACT []
synonym: "DISC" EXACT []
synonym: "DISC protein complex" EXACT []
xref: Wikipedia:Death-inducing_signaling_complex
is_a: GO:0098797 ! plasma membrane protein complex

AmiGO <GOterm>GO:0031264</GOterm>
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