MOUSE:CFLAR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cflar (synonyms: Cash)
Protein Name(s)	CASP8 and FADD-like apoptosis regulator Caspase homolog CASH Caspase-eight-related protein Casper Caspase-like apoptosis regulatory protein CLARP Cellular FLICE-like inhibitory protein c-FLIP FADD-like antiapoptotic molecule 1 FLAME-1 Inhibitor of FLICE I-FLICE MACH-related inducer of toxicity MRIT Usurpin CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12
External Links
UniProt	O35732
EMBL	Y14041 Y14042 U97076 AC112968
RefSeq	NP_001276633.1 NP_997536.1 XP_006495698.1
UniGene	Mm.336848 Mm.486313
ProteinModelPortal	O35732
SMR	O35732
BioGrid	198686
IntAct	O35732
MEROPS	C14.974
PhosphoSite	O35732
PRIDE	O35732
Ensembl	ENSMUST00000097722
GeneID	12633
KEGG	mmu:12633
UCSC	uc007bco.1
CTD	8837
MGI	MGI:1336166
eggNOG	NOG331323
GeneTree	ENSGT00530000064199
HOGENOM	HOG000069972
HOVERGEN	HBG050918
InParanoid	O35732
KO	K04724
OMA	KLFFIQN
OrthoDB	EOG74N5GK
Reactome	REACT_215122 REACT_243608 REACT_253999
ChiTaRS	Cflar
NextBio	281824
PRO	PR:O35732
Proteomes	UP000000589
Bgee	O35732
CleanEx	MM_CFLAR
ExpressionAtlas	O35732
Genevestigator	O35732
GO	GO:0004197 GO:0006915 GO:1901740 GO:0051092 GO:0042981 GO:0014842 GO:0014732 GO:0007519 GO:0043403 GO:0014866
Gene3D	1.10.533.10 3.40.50.1460
InterPro	IPR029030 IPR011029 IPR001875 IPR011600 IPR001309 IPR015917
Pfam	PF01335 PF00656
SMART	SM00115 SM00031
SUPFAM	SSF47986
PROSITE	PS50208 PS50168

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005737	cytoplasm	PMID:20100735^[1]	ECO:0000314			C		Fig.6A	complete
involved_in	GO:1901740	negative regulation of myoblast fusion	PMID:21364645^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21364645^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000188)	Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	PMID:21364645^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014866	skeletal myofibril assembly	PMID:21364645^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014842	regulation of skeletal muscle satellite cell proliferation	PMID:21364645^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	PMID:21364645^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	PMID:21364645^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000825075 UniProtKB:O15519	P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:97295 PANTHER:PTN000047947 UniProtKB:P42574 UniProtKB:Q14790	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010501 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033659 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:1277950 MGI:MGI:1312922 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:69274 UniProtKB:O15519 UniProtKB:P42574 UniProtKB:P55210 UniProtKB:P55211 UniProtKB:Q14790 WB:WBGene00000417	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033051 MGI:MGI:107739 MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:97295 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:70967 UniProtKB:O15519 UniProtKB:P31944 UniProtKB:Q95ND5 UniProtKB:Q9ULZ3 WB:WBGene00000417	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:22675671^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109324 MGI:MGI:2154952	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000347	positive regulation of hepatocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904036	negative regulation of epithelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903944	negative regulation of hepatocyte apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903845	negative regulation of cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903055	positive regulation of extracellular matrix organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:26582200^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	P		Seeded From UniProt	complete
part_of	GO:0097342	ripoptosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072126	positive regulation of glomerular mesangial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071732	cellular response to nitric oxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060546	negative regulation of necroptotic process	PMID:22675671^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2154952	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060546	negative regulation of necroptotic process	PMID:22089168^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060546	negative regulation of necroptotic process	PMID:21368763^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798 MGI:MGI:1261423 MGI:MGI:2154952	P	regulates_o_occurs_in:(CL:0000057)\|regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060544	regulation of necroptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21368763^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O89110	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:16263940^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:16263940^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:18686) regulates_o_occurs_in:(CL:0000670)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033574	response to testosterone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
part_of	GO:0031265	CD95 death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	C		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	C		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	C		Seeded From UniProt	complete
enables	GO:0016504	peptidase activator activity	PMID:21368763^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:1261423)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:23012479^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16263940^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18686) part_of:(CL:0000670)\|part_of:(EMAPA:18686) part_of:(CL:0000670)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	C		Seeded From UniProt	complete
enables	GO:0005123	death receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15519	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620847	F		Seeded From UniProt	complete
involved_in	GO:0010952	positive regulation of peptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016504	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008047	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008047	P		Seeded From UniProt	complete
involved_in	GO:2000347	positive regulation of hepatocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:1904036	negative regulation of epithelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:1903944	negative regulation of hepatocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:1903845	negative regulation of cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:1903055	positive regulation of extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0072126	positive regulation of glomerular mesangial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0071732	cellular response to nitric oxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
part_of	GO:0031265	CD95 death-inducing signaling complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	C		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
enables	GO:0005123	death receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C0H5Y5 ensembl:ENSRNOP00000016730	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	P		Seeded From UniProt	complete
part_of	GO:0097342	ripoptosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	C		Seeded From UniProt	complete
involved_in	GO:0060544	regulation of necroptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	P		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	C		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15519 ensembl:ENSP00000312455	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002398	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002398	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015917	F		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001875	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lin, YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol. Sci. 114 335-45 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Giampietri, C et al. (2010) c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging. Cell Death Dis 1 e38 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Dillon, CP et al. (2012) Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep 1 401-7 PubMed GONUTS page
↑ Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page
↑ Vanlangenakker, N et al. (2011) TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2 e230 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Oberst, A et al. (2011) Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471 363-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Giampietri, C et al. (2006) c-Flip expression and function in fetal mouse gonocytes. FASEB J. 20 124-6 PubMed GONUTS page
↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

[PMID:20100735-1] Lin, YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol. Sci. 114 335-45 PubMed GONUTS page

[PMID:21364645-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Giampietri, C et al. (2010) c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging. Cell Death Dis 1 e38 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22675671-4] 4.0 ^4.1 Dillon, CP et al. (2012) Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep 1 401-7 PubMed GONUTS page

[PMID:26582200-5] Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page

[PMID:22089168-6] Vanlangenakker, N et al. (2011) TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2 e230 PubMed GONUTS page

[PMID:21368763-7] 7.0 ^7.1 ^7.2 Oberst, A et al. (2011) Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471 363-7 PubMed GONUTS page

[PMID:16263940-8] 8.0 ^8.1 ^8.2 Giampietri, C et al. (2006) c-Flip expression and function in fetal mouse gonocytes. FASEB J. 20 124-6 PubMed GONUTS page

[PMID:23012479-9] Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

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MOUSE:CFLAR

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