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def: "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400]
comment: It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
synonym: "necrosome" RELATED 
synonym: "TNFR1 complex II" NARROW [PMID:22089168]
synonym: "Tnfr1-CII" NARROW [PMID:22089168]
is_a: GO:1902494 ! catalytic complex
relationship: part_of: GO:0005829 ! cytosol
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Pages in category "GO:0097342 ! ripoptosome"
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