HUMAN:TCAM1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TICAM1 (synonyms: PRVTIRB, TRIF)
Protein Name(s)	TIR domain-containing adapter molecule 1 TICAM-1 Proline-rich, vinculin and TIR domain-containing protein B Putative NF-kappa-B-activating protein 502H Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta MyD88-3 TIR domain-containing adapter protein inducing IFN-beta
External Links
UniProt	Q8IUC6
EMBL	AB093555 AB086380 AB446484 AB097023 BC009860 BC136556 BC136557 AF492646 AF070530
CCDS	CCDS12136.1
RefSeq	NP_891549.1
UniGene	Hs.29344
PDB	2M1X 2M63 3RC4 4BSX 4C0M
PDBsum	2M1X 2M63 3RC4 4BSX 4C0M
ProteinModelPortal	Q8IUC6
SMR	Q8IUC6
BioGrid	127114
DIP	DIP-33490N
IntAct	Q8IUC6
MINT	MINT-1202912
STRING	9606.ENSP00000248244
PhosphoSite	Q8IUC6
BioMuta	TICAM1
DMDM	74727957
MaxQB	Q8IUC6
PaxDb	Q8IUC6
PRIDE	Q8IUC6
Ensembl	ENST00000248244
GeneID	148022
KEGG	hsa:148022
UCSC	uc002mbi.4
CTD	148022
GeneCards	TICAM1
HGNC	HGNC:18348
HPA	HPA042460
MIM	607601 614850
neXtProt	NX_Q8IUC6
Orphanet	1930
PharmGKB	PA142670812
eggNOG	NOG67739
GeneTree	ENSGT00510000049574
HOGENOM	HOG000068973
HOVERGEN	HBG108551
InParanoid	Q8IUC6
KO	K05842
OMA	EEKLCPA
OrthoDB	EOG7GFB4H
PhylomeDB	Q8IUC6
TreeFam	TF336953
Reactome	R-HSA-140534 R-HSA-166166 R-HSA-1810476 R-HSA-2562578 R-HSA-5602566 R-HSA-5602571 R-HSA-936964 R-HSA-937041 R-HSA-937072
SignaLink	Q8IUC6
ChiTaRS	TICAM1
EvolutionaryTrace	Q8IUC6
GenomeRNAi	148022
NextBio	85815
PRO	PR:Q8IUC6
Proteomes	UP000005640
Bgee	Q8IUC6
CleanEx	HS_TICAM1
ExpressionAtlas	Q8IUC6
Genevisible	Q8IUC6
GO	GO:0005776 GO:0031410 GO:0005829 GO:0010008 GO:0097342 GO:0019901 GO:0004871 GO:0097296 GO:0006915 GO:0051607 GO:0097191 GO:0007249 GO:0006954 GO:0045087 GO:0031663 GO:0002281 GO:0002756 GO:0030890 GO:0045080 GO:0043123 GO:0045359 GO:0032755 GO:0032816 GO:0051092 GO:0045429 GO:0032092 GO:0031398 GO:0032760 GO:0012501 GO:0043496 GO:0043330 GO:0034138 GO:0034142 GO:0002224 GO:0035666
InterPro	IPR025735 IPR017278 IPR000157
Pfam	PF12721
PIRSF	PIRSF037744
SUPFAM	SSF52200

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	C		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P		Seeded From UniProt	complete
involved_in	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P		Seeded From UniProt	complete
involved_in	GO:1900017	positive regulation of cytokine production involved in inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P	occurs_in:(CL:0000235) part_of:(GO:1900017)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSG00000271503)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSG00000271503)	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P	occurs_in:(CL:0000235) causally_upstream_of:(GO:0010506)	Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q80UF7	P	occurs_in:(CL:0000235) part_of:(GO:0071222)	Seeded From UniProt	complete
part_of	GO:0097342	ripoptosome	PMID:21737330^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[2]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:14982987^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:14530355^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UHD2	F		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	PMID:21266579^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900017	positive regulation of cytokine production involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0050871	positive regulation of B cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	PMID:25636800^[6]	ECO:0000315			P		Fig 6G Greater dimerized IRF3 (type I interferon signal) is observed in wild type than mutant.	complete CACAO 11120
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:25636800^[6]	ECO:0000315			F		Figure 6F. Mutation of the S and T amino acids in TRIF reduced IRF3 dimerization, which is initiated by Serine/threonine phosphorylation	complete CACAO 11122
involved_in	GO:0043496	regulation of protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
	GO:0023014	signal transduction by protein phosphorylation	PMID:25636800^[6]	ECO:0000315			P		Fig 6G Greater dimerized/phosphorylated IRF3 (type I interferon signal) is observed in wild type than mutant TRIF(TCAM1).	complete CACAO 11174
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0032816	positive regulation of natural killer cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	C		Seeded From UniProt	complete
involved_in	GO:0002756	MyD88-independent toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80UF7 ensembl:ENSMUSP00000055104	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017278	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	Reactome:R-HSA-9013895 Reactome:R-HSA-2562564	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	Reactome:R-HSA-9013963 Reactome:R-HSA-2569057	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Reactome:R-HSA-937061 Reactome:R-HSA-936964 Reactome:R-HSA-9013973	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:R-HSA-168164	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034128	negative regulation of MyD88-independent toll-like receptor signaling pathway	Reactome:R-HSA-9014320 Reactome:R-HSA-2559568	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-9628444 Reactome:R-HSA-9014343 Reactome:R-HSA-9014342 Reactome:R-HSA-9014320 Reactome:R-HSA-9013992 Reactome:R-HSA-9013990 Reactome:R-HSA-9013986 Reactome:R-HSA-9013985 Reactome:R-HSA-9013979 Reactome:R-HSA-9013978 Reactome:R-HSA-9013974 Reactome:R-HSA-9013963 Reactome:R-HSA-9013895 Reactome:R-HSA-9013889 Reactome:R-HSA-847070 Reactome:R-HSA-5602624 Reactome:R-HSA-450259 Reactome:R-HSA-177694 Reactome:R-HSA-177692 Reactome:R-HSA-177690 Reactome:R-HSA-168930 Reactome:R-HSA-168929	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Reactome:R-HSA-937072 Reactome:R-HSA-9014325	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-937075 Reactome:R-HSA-937029 Reactome:R-HSA-936985 Reactome:R-HSA-936952 Reactome:R-HSA-936951 Reactome:R-HSA-936947 Reactome:R-HSA-936941 Reactome:R-HSA-5602712 Reactome:R-HSA-5362500 Reactome:R-HSA-5362486 Reactome:R-HSA-450358 Reactome:R-HSA-2569057 Reactome:R-HSA-2562564 Reactome:R-HSA-2562541 Reactome:R-HSA-2559568 Reactome:R-HSA-2213017 Reactome:R-HSA-2201338 Reactome:R-HSA-168929 Reactome:R-HSA-168921 Reactome:R-HSA-168915 Reactome:R-HSA-166271 Reactome:R-HSA-166245 Reactome:R-HSA-166175	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:R-HSA-168927 Reactome:R-HSA-166166	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0023	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Feoktistova, M et al. (2011) cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43 449-63 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ Jiang, Z et al. (2004) Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc. Natl. Acad. Sci. U.S.A. 101 3533-8 PubMed GONUTS page
↑ Sato, S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171 4304-10 PubMed GONUTS page
↑ Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page

[PMID:21737330-1] Feoktistova, M et al. (2011) cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43 449-63 PubMed GONUTS page

[PMID:12761501-2] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:14982987-3] Jiang, Z et al. (2004) Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc. Natl. Acad. Sci. U.S.A. 101 3533-8 PubMed GONUTS page

[PMID:14530355-4] Sato, S et al. (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171 4304-10 PubMed GONUTS page

[PMID:21266579-5] Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page

[PMID:25636800-6] 6.0 ^6.1 ^6.2 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page

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HUMAN:TCAM1

Contents

Annotations

Notes

References

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