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HUMAN:CASPA

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CASP10 (synonyms: MCH4)
Protein Name(s) Caspase-10

CASP-10 Apoptotic protease Mch-4 FAS-associated death domain protein interleukin-1B-converting enzyme 2 FLICE2 ICE-like apoptotic protease 4 Caspase-10 subunit p23/17 Caspase-10 subunit p12

External Links
UniProt Q92851
EMBL U60519
U86214
AF111344
AF111345
AB038979
AB038979
AJ487678
AJ487679
AY690601
EF050529
AC007283
CH471063
CH471063
BC042844
CCDS CCDS2338.1
CCDS2339.1
CCDS2340.1
CCDS56159.1
CCDS56160.1
RefSeq NP_001193453.1
NP_001193471.1
NP_001221.2
NP_116756.2
NP_116758.1
NP_116759.2
XP_005246967.1
XP_005246968.1
UniGene Hs.5353
ProteinModelPortal Q92851
SMR Q92851
BioGrid 107293
IntAct Q92851
MINT MINT-201954
STRING 9606.ENSP00000286186
BindingDB Q92851
ChEMBL CHEMBL5037
MEROPS C14.011
PhosphoSite Q92851
DMDM 12644463
MaxQB Q92851
PaxDb Q92851
PRIDE Q92851
Ensembl ENST00000272879
ENST00000286186
ENST00000313728
ENST00000346817
ENST00000360132
ENST00000374650
ENST00000448480
GeneID 843
KEGG hsa:843
UCSC uc002uxj.1
uc002uxk.1
uc002uxl.2
uc002uxm.2
uc010fta.1
uc010ftb.2
CTD 843
GeneCards GC02P202047
GeneReviews CASP10
HGNC HGNC:1500
HPA CAB003780
HPA017059
MIM 601762
603909
605027
613659
neXtProt NX_Q92851
Orphanet 3261
PharmGKB PA26084
eggNOG NOG303276
GeneTree ENSGT00760000118912
HOVERGEN HBG050803
InParanoid Q92851
KO K04400
OMA FTAKQCP
OrthoDB EOG7CRTQM
PhylomeDB Q92851
TreeFam TF102023
BRENDA 3.4.22.63
Reactome REACT_25039
REACT_402
REACT_900
ChiTaRS CASP10
GeneWiki Caspase_10
GenomeRNAi 843
NextBio 3530
PMAP-CutDB Q8IUP5
PRO PR:Q92851
Proteomes UP000005640
Bgee Q92851
CleanEx HS_CASP10
ExpressionAtlas Q92851
Genevestigator Q92851
GO GO:0031265
GO:0005737
GO:0005829
GO:0005886
GO:0097342
GO:0004197
GO:0097199
GO:0035877
GO:0031625
GO:0006915
GO:0097190
GO:0045087
GO:0043123
GO:0042981
Gene3D 1.10.533.10
3.40.50.1460
InterPro IPR029030
IPR011029
IPR001875
IPR011600
IPR001309
IPR016129
IPR002138
IPR015917
Pfam PF01335
PF00656
PRINTS PR00376
SMART SM00115
SM00031
SUPFAM SSF47986
PROSITE PS01122
PS01121
PS50207
PS50208
PS50168

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0097199

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:21980415[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

occurs_in:(CL:0010003)

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:16920334[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0097342

ripoptosome

PMID:21737330[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0097199

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:11717445[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12884866[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0035877

death effector domain binding

PMID:11717445[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13158

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:15069192[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8WZ73

F

Seeded From UniProt

complete

part_of

GO:0031265

CD95 death-inducing signaling complex

PMID:11717445[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

enables

GO:0097199

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026404
PANTHER:PTN000047948
UniProtKB:Q14790
UniProtKB:Q92851

F

Seeded From UniProt

complete

involved_in

GO:0097194

execution phase of apoptosis

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000825206
UniProtKB:Q14790

P

Seeded From UniProt

complete

enables

GO:0097153

cysteine-type endopeptidase activity involved in apoptotic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019972
MGI:MGI:107739
MGI:MGI:109383
MGI:MGI:1261423
MGI:MGI:97295
PANTHER:PTN000047947
UniProtKB:P42574
UniProtKB:Q14790

F

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026404
MGI:MGI:1261423
PANTHER:PTN000047948

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010501
FB:FBgn0020381
FB:FBgn0026404
FB:FBgn0028381
FB:FBgn0033659
MGI:MGI:107739
MGI:MGI:109383
MGI:MGI:1261423
MGI:MGI:1277950
MGI:MGI:1312922
PANTHER:PTN000047947
RGD:2274
RGD:2275
RGD:61867
RGD:620945
RGD:69274
UniProtKB:O15519
UniProtKB:P42574
UniProtKB:P55210
UniProtKB:P55211
UniProtKB:Q14790
WB:WBGene00000417

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019972
FB:FBgn0020381
FB:FBgn0026404
FB:FBgn0028381
FB:FBgn0033051
MGI:MGI:107739
MGI:MGI:1261423
MGI:MGI:1336166
MGI:MGI:97295
PANTHER:PTN000047947
RGD:2274
RGD:2275
RGD:61867
RGD:620945
RGD:70967
UniProtKB:O15519
UniProtKB:P31944
UniProtKB:Q95ND5
UniProtKB:Q9ULZ3
WB:WBGene00000417

C

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001309
InterPro:IPR002138
InterPro:IPR002398

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001309
InterPro:IPR002138
InterPro:IPR002398

P

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015917

F

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001875

P

Seeded From UniProt

complete

enables

GO:0097199

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR035701

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:10412980[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:10412980[8]
PMID:8755496[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

Reactome:R-HSA-75157

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

Reactome:R-HSA-5633008

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

Reactome:R-HSA-73887

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-933539
Reactome:R-HSA-933532
Reactome:R-HSA-933526
Reactome:R-HSA-933523
Reactome:R-HSA-6798139
Reactome:R-HSA-141316
Reactome:R-HSA-141310

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Zhang, Y et al. (2011) Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PLoS ONE 6 e25284 PubMed GONUTS page
  2. ↑ Wang, X et al. (2006) Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim. Biophys. Acta 1762 742-54 PubMed GONUTS page
  3. ↑ Feoktistova, M et al. (2011) cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43 449-63 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Wang, J et al. (2001) Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 98 13884-8 PubMed GONUTS page
  5. ↑ Shikama, Y et al. (2003) Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases. Eur. J. Immunol. 33 1998-2006 PubMed GONUTS page
  6. ↑ McDonald, ER 3rd & El-Deiry, WS (2004) Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 101 6170-5 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ 8.0 8.1 Wang, J et al. (1999) Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 98 47-58 PubMed GONUTS page
  9. ↑ Fernandes-Alnemri, T et al. (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. Sci. U.S.A. 93 7464-9 PubMed GONUTS page
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