HUMAN:TNF12

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TNFSF12 (synonyms: APO3L, DR3LG)
Protein Name(s)	Tumor necrosis factor ligand superfamily member 12 APO3 ligand TNF-related weak inducer of apoptosis TWEAK Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, secreted form
External Links
UniProt	O43508
EMBL	AF030099 AF055872 AY081051 AY358870 AC016876 BC019047
CCDS	CCDS11109.1
RefSeq	NP_003800.1 NP_742086.1
UniGene	Hs.54673
PDB	4HT1
PDBsum	4HT1
ProteinModelPortal	O43508
SMR	O43508
BioGrid	114279
IntAct	O43508
MINT	MINT-8415042
STRING	9606.ENSP00000293826
PhosphoSite	O43508
PaxDb	O43508
PRIDE	O43508
Ensembl	ENST00000293825
GeneID	407977 8742
KEGG	hsa:407977 hsa:8742
UCSC	uc002ghg.3 uc002ghi.1
CTD	407977 8742
GeneCards	GC17P007452
HGNC	HGNC:11927
MIM	602695
neXtProt	NX_O43508
Orphanet	1572
PharmGKB	PA162406662 PA36620
eggNOG	NOG45253
GeneTree	ENSGT00530000063837
HOGENOM	HOG000134435
HOVERGEN	HBG055510
InParanoid	O43508
KO	K05474
OMA	CQTELQS
OrthoDB	EOG79KPGF
PhylomeDB	O43508
TreeFam	TF332331
GeneWiki	TNFSF12 TNFSF12-TNFSF13
NextBio	108346
PRO	PR:O43508
Proteomes	UP000005640
Bgee	O43508
ExpressionAtlas	O43508
Genevestigator	O43508
GO	GO:0005615 GO:0005887 GO:0048471 GO:0005125 GO:0005102 GO:0001525 GO:0006915 GO:0097190 GO:0030154 GO:0043542 GO:0006955 GO:0045766 GO:0001938 GO:2001238 GO:0045732 GO:0007165
Gene3D	2.60.120.40
InterPro	IPR006052 IPR008983
Pfam	PF00229
SMART	SM00207
SUPFAM	SSF49842
PROSITE	PS50049

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:21525013^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(GO:0031264)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:14961121^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:17389268^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54907 ensembl:ENSMUSP00000137972	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54907 ensembl:ENSMUSP00000137972	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052	C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9560343^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:9560343^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9560343^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9560343^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:14961121^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	PMID:14961121^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:14961121^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5676594 Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5676598 Reactome:R-HSA-5669023 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668414	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5676598 Reactome:R-HSA-5669023 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668414	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:21525013^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21525013^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21525013^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ikner, A & Ashkenazi, A (2011) TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J. Biol. Chem. 286 21546-54 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Tian, XL et al. (2004) Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature 427 640-5 PubMed GONUTS page
↑ Li, HL et al. (2007) Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation 115 1885-94 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Marsters, SA et al. (1998) Identification of a ligand for the death-domain-containing receptor Apo3. Curr. Biol. 8 525-8 PubMed GONUTS page

[PMID:21525013-1] 1.0 ^1.1 ^1.2 ^1.3 Ikner, A & Ashkenazi, A (2011) TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J. Biol. Chem. 286 21546-54 PubMed GONUTS page

[PMID:14961121-2] 2.0 ^2.1 ^2.2 ^2.3 Tian, XL et al. (2004) Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature 427 640-5 PubMed GONUTS page

[PMID:17389268-3] Li, HL et al. (2007) Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation 115 1885-94 PubMed GONUTS page

[PMID:9560343-4] 4.0 ^4.1 ^4.2 ^4.3 Marsters, SA et al. (1998) Identification of a ligand for the death-domain-containing receptor Apo3. Curr. Biol. 8 525-8 PubMed GONUTS page

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HUMAN:TNF12

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