HUMAN:TRAF2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TRAF2 (synonyms: TRAP3)
Protein Name(s)	TNF receptor-associated factor 2 E3 ubiquitin-protein ligase TRAF2 Tumor necrosis factor type 2 receptor-associated protein 3
External Links
UniProt	Q12933
EMBL	U12597 AK054686 AK289722 AK298370 BX538160 AY623660 AL355987 AL449425 AL449425 AL355987 CH471090 BC032410 BC033810 BC043492 BC064662
CCDS	CCDS7013.1
PIR	S56163
RefSeq	NP_066961.2 XP_011517276.1 XP_011517277.1 XP_011517278.1 XP_011517279.1 XP_011517280.1
UniGene	Hs.522506
PDB	1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D
PDBsum	1CA4 1CA9 1CZY 1CZZ 1D00 1D01 1D0A 1D0J 1F3V 1QSC 3KNV 3M06 3M0A 3M0D
ProteinModelPortal	Q12933
SMR	Q12933
BioGrid	113038
DIP	DIP-6223N
IntAct	Q12933
MINT	MINT-107429
STRING	9606.ENSP00000247668
PhosphoSite	Q12933
BioMuta	TRAF2
DMDM	23503103
MaxQB	Q12933
PaxDb	Q12933
PRIDE	Q12933
DNASU	7186
Ensembl	ENST00000247668
GeneID	7186
KEGG	hsa:7186
UCSC	uc004cjv.3 uc010nbw.3 uc011mek.2
CTD	7186
GeneCards	TRAF2
H-InvDB	HIX0169360
HGNC	HGNC:12032
HPA	CAB004603 HPA009972 HPA010634
MIM	601895
neXtProt	NX_Q12933
PharmGKB	PA164742666
eggNOG	NOG264247
GeneTree	ENSGT00550000074359
HOGENOM	HOG000231558
HOVERGEN	HBG058222
InParanoid	Q12933
KO	K03173
OMA	SACRNVL
OrthoDB	EOG7966G5
PhylomeDB	Q12933
TreeFam	TF321154
Reactome	R-HSA-140534 R-HSA-3371378 R-HSA-5213460 R-HSA-5218900 R-HSA-5357786 R-HSA-5668541 R-HSA-5676594 R-HSA-69416 R-HSA-75893 R-HSA-933541 R-HSA-933542
SignaLink	Q12933
UniPathway	UPA00143
ChiTaRS	TRAF2
EvolutionaryTrace	Q12933
GeneWiki	TRAF2
GenomeRNAi	7186
NextBio	28172
PRO	PR:Q12933
Proteomes	UP000005640
Bgee	Q12933
CleanEx	HS_TRAF2
ExpressionAtlas	Q12933
Genevisible	Q12933
GO	GO:1990597 GO:0035631 GO:0005938 GO:0005737 GO:0009898 GO:0005829 GO:1990604 GO:0045121 GO:0097057 GO:0000151 GO:0012506 GO:0005174 GO:0019899 GO:0042802 GO:0016874 GO:0019901 GO:0019903 GO:0004871 GO:0046625 GO:0031996 GO:0005164 GO:0031625 GO:0004842 GO:0008270 GO:0006919 GO:0097296 GO:0007250 GO:0006915 GO:0007166 GO:0043623 GO:0071732 GO:0071550 GO:0097191 GO:0045087 GO:0070059 GO:0070266 GO:0043154 GO:0034351 GO:1901215 GO:2001238 GO:1903721 GO:0032743 GO:0043507 GO:0051092 GO:0090073 GO:0051091 GO:0050870 GO:0002726 GO:1903265 GO:0012501 GO:0097300 GO:0051865 GO:0030163 GO:0006461 GO:0051291 GO:0070207 GO:0070534 GO:0042981 GO:1902041 GO:0051023 GO:0010939 GO:0034976 GO:0007165 GO:0033209
Gene3D	2.60.210.10 3.30.40.10
InterPro	IPR002083 IPR012227 IPR008974 IPR027133 IPR018957 IPR001841 IPR013083 IPR017907 IPR001293
PANTHER	PTHR10131:SF21
Pfam	PF00097
PIRSF	PIRSF015614
SMART	SM00061 SM00184
SUPFAM	SSF49599
PROSITE	PS50144 PS00518 PS50089 PS50145

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:10650002^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:10650002^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z2E3	F		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	PMID:23000344^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:0097057	TRAF2-GSTP1 complex	PMID:16636664^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:17314283^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11728344^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NP84	F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12296995^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:12296995^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034622	cellular protein-containing complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39429	P		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39429	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16636664^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09211	F		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39429	C		Seeded From UniProt	complete
enables	GO:0005174	CD40 receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P39429	F		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:21525013^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(GO:0031264)	Seeded From UniProt	complete
involved_in	GO:0090073	positive regulation of protein homodimerization activity	PMID:11278723^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:20577214^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070534	protein K63-linked ubiquitination	PMID:15258597^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	PMID:20447407^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12933	P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:20577214^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15121867^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:11279055^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046625	sphingolipid binding	PMID:20577214^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:11907583^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:11907583^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:11907583^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032743	positive regulation of interleukin-2 production	PMID:15125833^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031996	thioesterase binding	PMID:11279055^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q93009	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:11279055^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O94972	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:15696169^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17706	F		Seeded From UniProt	complete
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	PMID:15125833^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11279055^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20333	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11279055^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92956	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11279055^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25942	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11279055^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36941	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11279055^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08138	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:20577214^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	PMID:15258597^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002726	positive regulation of T cell cytokine production	PMID:15125833^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 PANTHER:PTN002562153 UniProtKB:Q12933	C		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 PANTHER:PTN002562153 RGD:1310457 UniProtKB:Q12933	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 PANTHER:PTN002562153 RGD:1310457	C		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002562153 RGD:1310457 UniProtKB:Q12933	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 MGI:MGI:107548 MGI:MGI:108041 MGI:MGI:108072 PANTHER:PTN000805648 RGD:1306853 RGD:1310457 UniProtKB:Q12933 UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
enables	GO:0031996	thioesterase binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002562153 UniProtKB:Q12933	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002562153 RGD:1310457 UniProtKB:Q12933	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 PANTHER:PTN002562153 UniProtKB:Q12933	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002562153 UniProtKB:Q12933	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9020361^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12933	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:8069916^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12933	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:30561431^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12933	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12933	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20562859^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12933	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16189514^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12933	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	F		Seeded From UniProt	complete
involved_in	GO:0034351	negative regulation of glial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	C		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	F		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFH7 ensembl:ENSRNOP00000008253	C		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
part_of	GO:1990597	AIP1-IRE1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
involved_in	GO:1903721	positive regulation of I-kappaB phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
involved_in	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
involved_in	GO:0097300	programmed necrotic cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
involved_in	GO:0071732	cellular response to nitric oxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
involved_in	GO:0051023	regulation of immunoglobulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
involved_in	GO:0034622	cellular protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	C		Seeded From UniProt	complete
enables	GO:0005174	CD40 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39429 ensembl:ENSMUSP00000109872	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027133 InterPro:IPR037305	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027133 InterPro:IPR037305	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227	P		Seeded From UniProt	complete
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027133 InterPro:IPR037305	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001293 InterPro:IPR012227	F		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027133 InterPro:IPR037305	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227 InterPro:IPR027133 InterPro:IPR037305	P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027133 InterPro:IPR037305	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018957	F		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027133 InterPro:IPR037305	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:22013210^[24] PMID:14685163^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:18221368^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8702708^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:8702708^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051865	protein autoubiquitination	PMID:16378096^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Reactome:R-HSA-5675456 Reactome:R-HSA-3465429	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	Reactome:R-HSA-3371378	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071550	death-inducing signaling complex assembly	Reactome:R-HSA-5357786	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-75893 Reactome:R-HSA-5676594 Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5357905	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Reactome:R-HSA-5357956	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Reactome:R-HSA-69416	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-933538 Reactome:R-HSA-933537 Reactome:R-HSA-933530 Reactome:R-HSA-933527 Reactome:R-HSA-933525 Reactome:R-HSA-918230 Reactome:R-HSA-8869456 Reactome:R-HSA-83656 Reactome:R-HSA-83582 Reactome:R-HSA-75240 Reactome:R-HSA-5696627 Reactome:R-HSA-5693108 Reactome:R-HSA-5693055 Reactome:R-HSA-5676598 Reactome:R-HSA-5676597 Reactome:R-HSA-5676596 Reactome:R-HSA-5676595 Reactome:R-HSA-5676593 Reactome:R-HSA-5675456 Reactome:R-HSA-5668543 Reactome:R-HSA-5668534 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668417 Reactome:R-HSA-5668414 Reactome:R-HSA-5634221 Reactome:R-HSA-5357928 Reactome:R-HSA-5357904 Reactome:R-HSA-5357860 Reactome:R-HSA-5357845 Reactome:R-HSA-5357828 Reactome:R-HSA-5357780 Reactome:R-HSA-5357776 Reactome:R-HSA-5357757 Reactome:R-HSA-3465448 Reactome:R-HSA-3465429 Reactome:R-HSA-3371360 Reactome:R-HSA-141159 Reactome:R-HSA-140978 Reactome:R-HSA-139952	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8862184	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Urano, F et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 664-6 PubMed GONUTS page
↑ Zheng, QY et al. (2013) Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell. Signal. 25 206-13 PubMed GONUTS page
↑ ^3.0 ^3.1 Wu, Y et al. (2006) Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene 25 5787-800 PubMed GONUTS page
↑ Henn, IH et al. (2007) Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling. J. Neurosci. 27 1868-78 PubMed GONUTS page
↑ Wiley, SR et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15 837-46 PubMed GONUTS page
↑ ^6.0 ^6.1 Lee, SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J. Biochem. Mol. Biol. 35 371-6 PubMed GONUTS page
↑ Ikner, A & Ashkenazi, A (2011) TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J. Biol. Chem. 286 21546-54 PubMed GONUTS page
↑ Yoneda, T et al. (2001) Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J. Biol. Chem. 276 13935-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Alvarez, SE et al. (2010) Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465 1084-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Wertz, IE et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430 694-9 PubMed GONUTS page
↑ Mace, PD et al. (2010) Asymmetric recruitment of cIAPs by TRAF2. J. Mol. Biol. 400 8-15 PubMed GONUTS page
↑ Gil, J et al. (2004) TRAF family proteins link PKR with NF-kappa B activation. Mol. Cell. Biol. 24 4502-12 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Li, X et al. (2002) TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416 345-7 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Sun, L et al. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14 289-301 PubMed GONUTS page
↑ van Vliet, C et al. (2005) Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat. Immunol. 6 253-60 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Malinin, NL et al. (1997) MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 385 540-4 PubMed GONUTS page
↑ Rothe, M et al. (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78 681-92 PubMed GONUTS page
↑ Van Quickelberghe, E et al. (2018) A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Sci Data 5 180289 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ Behrends, C et al. (2010) Network organization of the human autophagy system. Nature 466 68-76 PubMed GONUTS page
↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page
↑ Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page
↑ Oyadomari, S & Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 381-9 PubMed GONUTS page
↑ Mills, RD et al. (2008) Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). J. Neurochem. 105 18-33 PubMed GONUTS page
↑ ^27.0 ^27.1 Takeuchi, M et al. (1996) Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. 271 19935-42 PubMed GONUTS page
↑ Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

[PMID:10650002-1] 1.0 ^1.1 Urano, F et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 664-6 PubMed GONUTS page

[PMID:23000344-2] Zheng, QY et al. (2013) Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell. Signal. 25 206-13 PubMed GONUTS page

[PMID:16636664-3] 3.0 ^3.1 Wu, Y et al. (2006) Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene 25 5787-800 PubMed GONUTS page

[PMID:17314283-4] Henn, IH et al. (2007) Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling. J. Neurosci. 27 1868-78 PubMed GONUTS page

[PMID:11728344-5] Wiley, SR et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15 837-46 PubMed GONUTS page

[PMID:12296995-6] 6.0 ^6.1 Lee, SW et al. (2002) TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J. Biochem. Mol. Biol. 35 371-6 PubMed GONUTS page

[PMID:21525013-7] Ikner, A & Ashkenazi, A (2011) TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J. Biol. Chem. 286 21546-54 PubMed GONUTS page

[PMID:11278723-8] Yoneda, T et al. (2001) Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J. Biol. Chem. 276 13935-40 PubMed GONUTS page

[PMID:20577214-9] 9.0 ^9.1 ^9.2 ^9.3 Alvarez, SE et al. (2010) Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465 1084-8 PubMed GONUTS page

[PMID:15258597-10] 10.0 ^10.1 Wertz, IE et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430 694-9 PubMed GONUTS page

[PMID:20447407-11] Mace, PD et al. (2010) Asymmetric recruitment of cIAPs by TRAF2. J. Mol. Biol. 400 8-15 PubMed GONUTS page

[PMID:15121867-12] Gil, J et al. (2004) TRAF family proteins link PKR with NF-kappa B activation. Mol. Cell. Biol. 24 4502-12 PubMed GONUTS page

[PMID:11279055-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page

[PMID:11907583-14] 14.0 ^14.1 ^14.2 Li, X et al. (2002) TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416 345-7 PubMed GONUTS page

[PMID:15125833-15] 15.0 ^15.1 ^15.2 Sun, L et al. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14 289-301 PubMed GONUTS page

[PMID:15696169-16] van Vliet, C et al. (2005) Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat. Immunol. 6 253-60 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9020361-18] Malinin, NL et al. (1997) MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 385 540-4 PubMed GONUTS page

[PMID:8069916-19] Rothe, M et al. (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78 681-92 PubMed GONUTS page

[PMID:30561431-20] Van Quickelberghe, E et al. (2018) A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Sci Data 5 180289 PubMed GONUTS page

[PMID:25416956-21] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:20562859-22] Behrends, C et al. (2010) Network organization of the human autophagy system. Nature 466 68-76 PubMed GONUTS page

[PMID:16189514-23] Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page

[PMID:22013210-24] Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

[PMID:14685163-25] Oyadomari, S & Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 381-9 PubMed GONUTS page

[PMID:18221368-26] Mills, RD et al. (2008) Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). J. Neurochem. 105 18-33 PubMed GONUTS page

[PMID:8702708-27] 27.0 ^27.1 Takeuchi, M et al. (1996) Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. 271 19935-42 PubMed GONUTS page

[PMID:16378096-28] Wang, Y et al. (2006) Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7 139-47 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

HUMAN:TRAF2

Contents

Annotations

Notes

References

a

c

d

e

h

i

l

m

n

o

p

r

s

t

u

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools