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PMID:14685163

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Citation

Oyadomari, S and Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11:381-9

Abstract

Endoplasmic reticulum (ER) is the site of synthesis and folding of secretory proteins. Perturbations of ER homeostasis affect protein folding and cause ER stress. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER chaperones and related proteins, and degradation of unfolded proteins by a quality-control system. However, when the ER function is severely impaired, the organelle elicits apoptotic signals. ER stress has been implicated in a variety of common diseases such as diabetes, ischemia and neurodegenerative disorders. One of the components of the ER stress-mediated apoptosis pathway is C/EBP homologous protein (CHOP), also known as growth arrest- and DNA damage-inducible gene 153 (GADD153). Here, we summarize the current understanding of the roles of CHOP/GADD153 in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease.

Links

PubMed Online version:10.1038/sj.cdd.4401373

Keywords

Animals; Apoptosis/physiology; CCAAT-Enhancer-Binding Proteins/chemistry; CCAAT-Enhancer-Binding Proteins/metabolism; Cell Differentiation/physiology; Cell Division/physiology; Disease/etiology; Endoplasmic Reticulum/metabolism; Humans; Mice; Stress, Physiological/metabolism; Transcription Factor CHOP; Transcription Factors/chemistry; Transcription Factors/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:DAPK3

enables

GO:0008140: cAMP response element binding protein binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

  • has_input:(UniProtKB:P18848)

Seeded From UniProt

complete

HUMAN:BIP

enables

GO:0051082: unfolded protein binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:CEBPB

involved_in

GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ATF3

involved_in

GO:0061394: regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • has_input:(UniProtKB:P35638)

Seeded From UniProt

complete

HUMAN:ATF4

involved_in

GO:0061395: positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • has_input:(UniProtKB:P35638)

Seeded From UniProt

complete

HUMAN:DDIT3

involved_in

GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DDIT3

involved_in

GO:0036499: PERK-mediated unfolded protein response

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CEBPA

involved_in

GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • has_input:(UniProtKB:P24941)|has_input:(UniProtKB:P11802)

Seeded From UniProt

complete

HUMAN:CEBPA

involved_in

GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TRAF2

involved_in

GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ATF4

involved_in

GO:0061395: positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

has_regulation_target:(UniProtKB:P35638)

Seeded From UniProt

complete

HUMAN:DDIT3

enables

GO:0046982: protein heterodimerization activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:DDIT3

part_of

GO:0005829: cytosol

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:DDIT3

part_of

GO:0036488: CHOP-C/EBP complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:DDIT3

involved_in

GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

HUMAN:TRAF2

involved_in

GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

HUMAN:BIP

involved_in

GO:0090074: negative regulation of protein homodimerization activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • has_regulation_target:(UniProtKB:O75460)
  • part_of:(GO:0034976)|has_regulation_target(UniProtKB:Q76MJ5)
  • part_of:(GO:0034976)|has_regulation_target(UniProtKB:Q9NZJ5)
  • part_of:(GO:0034976)

Seeded From UniProt

complete

HUMAN:BIP

involved_in

GO:1990440: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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