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PMID:8069916
| Citation |
Rothe, M, Wong, SC, Henzel, WJ and Goeddel, DV (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681-92 |
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| Abstract |
Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmic domain of the human 75 kDa tumor necrosis factor receptor (TNF-R2) that is required for signal transduction. This region was subsequently shown to mediate the interaction of cytoplasmic factors with TNF-R2. Two of these factors were isolated and molecularly cloned using biochemical purification and the yeast two-hybrid system. TNF receptor-associated factor 1 (TRAF1) and TRAF2 are the first two members of a novel protein family containing a novel C-terminal homology region, the TRAF domain. In addition, TRAF2 contains an N-terminal RING finger motif. TRAF1 and TRAF2 can form homo- and heterotypic dimers. Our analysis indicates that TRAF1 and TRAF2 are associated with the cytoplasmic domain of TNF-R2 in a heterodimeric complex in which TRAF2 contacts the receptor directly. TRAF1 interacts with TNF-R2 indirectly through heterodimer formation with TRAF2. |
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| Keywords |
Amino Acid Sequence; Animals; Antigens, CD; Base Sequence; Cloning, Molecular; Cytoplasm/chemistry; Humans; Mice; Models, Biological; Molecular Sequence Data; Organ Specificity; Protein Conformation; Protein Structure, Tertiary; Proteins/chemistry; Proteins/genetics; Proteins/metabolism; RNA, Messenger/analysis; Receptors, Tumor Necrosis Factor/metabolism; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/isolation & purification; Recombinant Fusion Proteins/metabolism; Sequence Alignment; Sequence Analysis; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Signal Transduction/genetics; TNF Receptor-Associated Factor 1; TNF Receptor-Associated Factor 2 |
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Significance
Annotations
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