MOUSE:CASP3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Casp3 (synonyms: Cpp32)
Protein Name(s)	Caspase-3 CASP-3 Apopain Cysteine protease CPP32 CPP-32 LICE Protein Yama SREBP cleavage activity 1 SCA-1 Caspase-3 subunit p17 Caspase-3 subunit p12
External Links
UniProt	P70677
EMBL	U54803 U54802 U49929 D86352 Y13086 U19522 BC038825 U63720
CCDS	CCDS22294.1
PIR	JC5410
RefSeq	NP_001271338.1 NP_033940.1
UniGene	Mm.34405
ProteinModelPortal	P70677
SMR	P70677
BioGrid	198497
DIP	DIP-44076N
IntAct	P70677
MINT	MINT-4050331
BindingDB	P70677
ChEMBL	CHEMBL5632
MEROPS	C14.003
PhosphoSite	P70677
MaxQB	P70677
PaxDb	P70677
PRIDE	P70677
Ensembl	ENSMUST00000093517
GeneID	12367
KEGG	mmu:12367
UCSC	uc009lql.1
CTD	836
MGI	MGI:107739
eggNOG	NOG279444
GeneTree	ENSGT00760000118912
HOGENOM	HOG000231878
HOVERGEN	HBG050802
InParanoid	P70677
KO	K02187
OMA	YASEYNM
OrthoDB	EOG7TTQ7K
PhylomeDB	P70677
TreeFam	TF102023
BRENDA	3.4.22.56
Reactome	REACT_196537 REACT_199052 REACT_205002 REACT_210562 REACT_210754 REACT_211941 REACT_212869 REACT_224460 REACT_225157 REACT_252543
ChiTaRS	Casp3
NextBio	281052
PRO	PR:P70677
Proteomes	UP000000589
Bgee	P70677
CleanEx	MM_CASP3
ExpressionAtlas	P70677
Genevestigator	P70677
GO	GO:0005737 GO:0005829 GO:0005634 GO:0004190 GO:0004861 GO:0004197 GO:0097153 GO:0097200 GO:0008234 GO:0008233 GO:0004252 GO:0006915 GO:0001782 GO:0045165 GO:0006974 GO:0071310 GO:0030218 GO:0097194 GO:0097192 GO:0008625 GO:0034349 GO:0007507 GO:0008631 GO:0030216 GO:0046007 GO:0043066 GO:0030889 GO:0045786 GO:0045736 GO:0051402 GO:0030182 GO:0043065 GO:0043525 GO:0016485 GO:1902510 GO:0001836 GO:0009411 GO:0009611 GO:0007605 GO:0043029
Gene3D	3.40.50.1460
InterPro	IPR029030 IPR015470 IPR011600 IPR001309 IPR016129 IPR002138 IPR015917
PANTHER	PTHR10454:SF30
Pfam	PF00656
PRINTS	PR00376
SMART	SM00115
PROSITE	PS01122 PS01121 PS50207 PS50208

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:24478317^[1]	ECO:0000315			P		Figure 8. Following LeTx injection, the bone marrow and lung of WT mice showed numerous positive cells for cleaved caspase 3.	complete CACAO 9633
involved_in	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42574	F		Seeded From UniProt	complete
involved_in	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress	PMID:21716255^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21716255^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21716255^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:12097332^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:19759058^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P51859)\|has_direct_input:(UniProtKB:Q80XU3)\|has_direct_input:(UniProtKB:P19157)\|has_direct_input:(UniProtKB:O08585)\|has_direct_input:(UniProtKB:O88271)\|has_direct_input:(UniProtKB:O88568)\|has_direct_input:(UniProtKB:P08113)\|has_direct_input:(UniProtKB:P12367)\|has_direct_input:(UniProtKB:P16675)\|has_direct_input:(UniProtKB:P17225)\|has_direct_input:(UniProtKB:P20152)\|has_direct_input:(UniProtKB:P26369)\|has_direct_input:(UniProtKB:P47713)\|has_direct_input:(UniProtKB:P47962)\|has_direct_input:(UniProtKB:P49710)\|has_direct_input:(UniProtKB:P50516)\|has_direct_input:(UniProtKB:P50518)\|has_direct_input:(UniProtKB:P52480)\|has_direct_input:(UniProtKB:P54227)\|has_direct_input:(UniProtKB:P56399)\|has_direct_input:(UniProtKB:P58252)\|has_direct_input:(UniProtKB:P60710)\|has_direct_input:(UniProtKB:P62196)\|has_direct_input:(UniProtKB:P62737)\|has_direct_input:(UniProtKB:P63038)\|has_direct_input:(UniProtKB:P70188)\|has_direct_input:(UniProtKB:Q3TC93)\|has_direct_input:(UniProtKB:Q6PEB6)\|has_direct_input:(UniProtKB:Q6PGL7)\|has_direct_input:(UniProtKB:Q6ZQ58)\|has_direct_input:(UniProtKB:Q8BTI8)\|has_direct_input:(UniProtKB:Q8BVE3)\|has_direct_input:(UniProtKB:Q8R0K4)\|has_direct_input:(UniProtKB:Q8R574)\|has_direct_input:(UniProtKB:Q8VDD5)\|has_direct_input:(UniProtKB:Q91VR5)\|has_direct_input:(UniProtKB:Q921F2)\|has_direct_input:(UniProtKB:Q922B2)\|has_direct_input:(UniProtKB:Q923D5)\|has_direct_input:(UniProtKB:Q9CPW4)\|has_direct_input:(UniProtKB:Q9CR98)\|has_direct_input:(UniProtKB:Q9WUK2)\|has_direct_input:(UniProtKB:P11103)	Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:97295 PANTHER:PTN000047947 UniProtKB:P42574 UniProtKB:Q14790	F		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048337 UniProtKB:P42574	P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107739 PANTHER:PTN000048337	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048337 RGD:2275	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010501 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033659 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:1277950 MGI:MGI:1312922 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:69274 UniProtKB:O15519 UniProtKB:P42574 UniProtKB:P55210 UniProtKB:P55211 UniProtKB:Q14790 WB:WBGene00000417	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033051 MGI:MGI:107739 MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:97295 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:70967 UniProtKB:O15519 UniProtKB:P31944 UniProtKB:Q95ND5 UniProtKB:Q9ULZ3 WB:WBGene00000417	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
enables	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	PMID:12124386^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	F		Seeded From UniProt	complete
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	PMID:16469926^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109383	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	PMID:11549719^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2651856	P	occurs_in:(EMAPA:16665)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	PMID:15456877^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	PMID:12954857^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	PMID:12124386^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097194	execution phase of apoptosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:24378336^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:16183742^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072734	cellular response to staurosporine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071310	cellular response to organic substance	PMID:12606450^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:10618441^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88139	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:11549719^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2651856	P	occurs_in:(EMAPA:16665)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:10618441^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158753	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:10479688^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2651856	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:15231831^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:12427836^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048011	neurotrophin TRK receptor signaling pathway	PMID:23954828^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046007	negative regulation of activated T cell proliferation	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:15068794^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043029	T cell homeostasis	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034349	glial cell apoptotic process	PMID:11549719^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2651856	P	occurs_in:(EMAPA:16668)\|occurs_in:(EMAPA:16797)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031647	regulation of protein stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030889	negative regulation of B cell proliferation	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030218	erythrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030216	keratinocyte differentiation	PMID:15068794^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P	occurs_in:(EMAPA:16039) results_in_acquisition_of_features_of:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:15231831^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(MGI:MGI:88139)	Seeded From UniProt	complete
enables	GO:0016005	phospholipase A2 activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	PMID:17475835^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009749	response to glucose	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:14507967^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009411	response to UV	PMID:16469926^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109383	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009411	response to UV	PMID:11092819^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	PMID:17544522^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:16469926^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158753	F	occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:11549719^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(EMAPA:16797) occurs_in:(CL:0000540) has_direct_input:(MGI:MGI:88059)\|occurs_in(EMAPA:16668) occurs_in:(CL:0000540) has_direct_input:(MGI:MGI:88059)	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:14561754^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:13679151^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:12954857^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:12427836^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:12819136^[27]	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:11374883^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2684608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:16469926^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109383	P	results_in_development_of:(EMAPA:16688)\|results_in_development_of:(EMAPA:17331)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007413	axonal fasciculation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:11092819^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16910) occurs_in:(CL:0000540)\|occurs_in:(EMAPA:16910) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:9512515^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:16469926^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158753	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:17901126^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:29915) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:12847083^[31]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	PMID:12819136^[27]	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25139234^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23861879^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12477715^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22358842^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	C		Seeded From UniProt	complete
enables	GO:0005123	death receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	F		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:15456877^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:14657025^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P42574	F		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:23727203^[37]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:2142824)	Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:15231831^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:88139)	Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001782	B cell homeostasis	PMID:12970760^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178778	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016005	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016005	P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
enables	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	F		Seeded From UniProt	complete
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	F		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	F		Seeded From UniProt	complete
involved_in	GO:0072734	cellular response to staurosporine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42574 ensembl:ENSP00000311032	F		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0071887	leukocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0034349	glial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0032025	response to cobalt ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
enables	GO:0016005	phospholipase A2 activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0010038	response to metal ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0007413	axonal fasciculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
enables	GO:0005123	death receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0001554	luteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015917	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-2534247 Reactome:R-MMU-418855	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rivera, J et al. (2014) Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. 289 7131-41 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Küper, C et al. (2011) Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. Kidney Int. 80 938-945 PubMed GONUTS page
↑ Morishima, N et al. (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem. 277 34287-94 PubMed GONUTS page
↑ Demon, D et al. (2009) Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity. Mol. Cell Proteomics 8 2700-14 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Xu, J et al. (2002) The role of Asp-462 in regulating Akt activity. J. Biol. Chem. 277 35561-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lakhani, SA et al. (2006) Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311 847-51 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Simpson, MT et al. (2001) Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J. Neurosci. 21 7089-98 PubMed GONUTS page
↑ ^9.0 ^9.1 Biju, MP et al. (2004) Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 24 9038-47 PubMed GONUTS page
↑ ^10.0 ^10.1 Garnier, P et al. (2003) Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1. J. Neurosci. 23 7967-73 PubMed GONUTS page
↑ Huang, T & Krimm, RF (2014) BDNF and NT4 play interchangeable roles in gustatory development. Dev. Biol. 386 308-20 PubMed GONUTS page
↑ Berube, C et al. (2005) Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc. Natl. Acad. Sci. U.S.A. 102 14314-20 PubMed GONUTS page
↑ Mu, J et al. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol. Reprod. 68 1968-74 PubMed GONUTS page
↑ ^14.0 ^14.1 Roth, KA et al. (2000) Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 97 466-71 PubMed GONUTS page
↑ Cregan, SP et al. (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J. Neurosci. 19 7860-9 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Pozniak, CD et al. (2002) p73 is required for survival and maintenance of CNS neurons. J. Neurosci. 22 9800-9 PubMed GONUTS page
↑ Pan, Y et al. (2013) Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Neurosci. Lett. 553 46-51 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 ^19.8 Woo, M et al. (2003) Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat. Immunol. 4 1016-22 PubMed GONUTS page
↑ ^20.0 ^20.1 Okuyama, R et al. (2004) High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism. Dev. Cell 6 551-62 PubMed GONUTS page
↑ Kuo, CC et al. (2007) Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide. J. Immunol. 178 6100-8 PubMed GONUTS page
↑ Dong, H et al. (2003) Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J. Neurosci. 23 8682-91 PubMed GONUTS page
↑ ^23.0 ^23.1 D'Sa-Eipper, C et al. (2001) DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development 128 137-46 PubMed GONUTS page
↑ Hata, T & Nakayama, M (2007) Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death. Biochim. Biophys. Acta 1773 1039-51 PubMed GONUTS page
↑ Rao, RV et al. (2004) Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J. Biol. Chem. 279 177-87 PubMed GONUTS page
↑ Takagi, Y et al. (2003) Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst.) 2 1135-46 PubMed GONUTS page
↑ ^27.0 ^27.1 Reed, JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 13 1376-88 PubMed GONUTS page
↑ Morishita, H et al. (2001) Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem. Biophys. Res. Commun. 284 142-9 PubMed GONUTS page
↑ Woo, M et al. (1998) Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 12 806-19 PubMed GONUTS page
↑ Yin, Y et al. (2008) Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol. Endocrinol. 22 113-25 PubMed GONUTS page
↑ Zong, WX et al. (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J. Cell Biol. 162 59-69 PubMed GONUTS page
↑ Zhang, P et al. (2014) Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice. Biochem. Biophys. Res. Commun. 452 53-9 PubMed GONUTS page
↑ Stegeman, S et al. (2013) Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis. PLoS ONE 8 e68287 PubMed GONUTS page
↑ Baliga, BC et al. (2003) Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. J. Biol. Chem. 278 4899-905 PubMed GONUTS page
↑ Cheung, TH et al. (2012) Maintenance of muscle stem-cell quiescence by microRNA-489. Nature 482 524-8 PubMed GONUTS page
↑ Rajpal, A et al. (2003) Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J. 22 6526-36 PubMed GONUTS page
↑ Shimizu, K & Sawasaki, T (2013) Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity. FEBS Lett. 587 2219-25 PubMed GONUTS page

[PMID:24478317-1] Rivera, J et al. (2014) Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. 289 7131-41 PubMed GONUTS page

[PMID:21716255-2] 2.0 ^2.1 ^2.2 Küper, C et al. (2011) Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. Kidney Int. 80 938-945 PubMed GONUTS page

[PMID:12097332-3] Morishima, N et al. (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem. 277 34287-94 PubMed GONUTS page

[PMID:19759058-4] Demon, D et al. (2009) Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity. Mol. Cell Proteomics 8 2700-14 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12124386-6] 6.0 ^6.1 Xu, J et al. (2002) The role of Asp-462 in regulating Akt activity. J. Biol. Chem. 277 35561-6 PubMed GONUTS page

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MOUSE:CASP3

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