GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:24478317
| Citation |
'Rivera, J, Sellers, RS, Zeng, W, van Rooijen, N, Casadevall, A and Goldman, DL (2014) Platelet Activating Factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. ' |
|---|---|
| Abstract |
The lethal toxin (LeTx) of B. anthracis plays a central role in the pathogenesis of anthrax-associated shock. Platelet activating factor (PAF) is a potent lipid mediator that has been implicated in endotoxin-associated shock. In this study, we examined the contribution of PAF to the manifestations of lethal toxin challenge in WT mice. LeTx challenge resulted in transient increase in serum PAF levels and a concurrent decrease in PAF acetylhydrolase activity. Inhibition of PAF activity using PAF antagonists or toxin challenge of PAF receptor negative mice reversed or ameliorated many of the pathologic features of LeTx-induced damage, including changes in vascular permeability, hepatic necrosis and cellular apoptosis. In contrast, PAF inhibition had minimal effects on cytokine levels. Findings from these studies support the continued study of PAF-antagonists as potential adjunctive agents in the treatment of anthrax-associated shock. |
| Links |
PubMed PMC3945373 Online version:10.1074/jbc.M113.524900 |
| Keywords |
|
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314: |
P |
NLRP1 is a nod like receptor that mediates the effects of LeTx for macrophage viability |
complete | ||||
| GO:0006508: proteolysis |
ECO:0000314: |
P |
Figure 9. |
complete | ||||
| GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000315: |
P |
Figure 8. Following LeTx injection, the bone marrow and lung of WT mice showed numerous positive cells for cleaved caspase 3. |
complete | ||||
| GO:0016239: positive regulation of macroautophagy |
ECO:0000315: |
P |
Figure 1. Compared PAF measurements in vivo following LeTx injection. |
complete | ||||
| GO:0035455: response to interferon-alpha |
ECO:0000314: |
P |
IFN-alpha was used in the concentrations as stated by the manufacturer in cytokine and chemokine study |
complete | ||||
| GO:0042104: positive regulation of activated T cell proliferation |
ECO:0000315: |
P |
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Figure 2 shows an evidentiary correlation between IL-2 and T-cell activities in mice. |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
